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Votrient 400mg - Pazopanib Tablets

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Votrient 400mg - Pazopanib Tablets

Votrient 400mg is a targeted anti-cancer medication used primarily in the treatment of kidney cancer and advanced soft tissue sarcoma. It inhibits the growth and spread of cancer cells by blocking the formation of blood vessels that feed tumors.

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Description Product Details
General Information:
Generic Name: Pazopanib
Brand Name: Votrient
Packing: Bottle of 30 film-coated tablets
Strength: 400 mg
Manufacturer: Novartis Pharmaceuticals
Form: Tablet (oral use)
Category: Anti-cancer, Targeted Therapy, Tyrosine Kinase Inhibitor (TKI)
Product Intro:
Votrient 400mg is an oral medication used in the treatment of advanced renal cell carcinoma (RCC) and soft tissue sarcoma (STS). It is part of the tyrosine kinase inhibitor (TKI) class of drugs, which target specific enzymes involved in cancer cell growth and blood vessel formation.
Uses:
  1. Advanced Renal Cell Carcinoma (RCC)
  2. Soft Tissue Sarcoma (STS) after chemotherapy failure
  3. Treatment of metastatic cancers responsive to angiogenesis inhibition
  4. Under investigation for thyroid cancers
  5. Used when conventional chemotherapy has limited efficacy
  6. Helps to prolong progression-free survival
Storage Instructions:
  1. Store below 30°C (86°F) in a dry, cool place
  2. Protect from moisture and direct light
  3. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Pazopanib works by inhibiting tyrosine kinases like VEGFR, PDGFR, and c-Kit, which are essential for tumor angiogenesis and cell proliferation.
It blocks the blood supply to tumors, effectively starving them of oxygen and nutrients, leading to slowed growth and eventual death of cancer cells.
Side Effects:
Common Side Effects:
  1. Fatigue
  2. Nausea
  3. Diarrhea
  4. High blood pressure
  5. Hair color changes
  6. Appetite loss
  7. Headache
Severe Side Effects:
  1. Elevated liver enzymes or liver damage
  2. QT interval prolongation (heart rhythm changes)
  3. Severe bleeding or blood clots
  4. Gastrointestinal perforation
  5. Proteinuria
  6. Wound healing complications
Dosage (Typical Recommended Dose):
  1. Standard adult dose: 800 mg once daily, often taken as two 400mg tablets
  2. Dose may be adjusted based on tolerance, liver function, or side effects
  3. Dose modifications may involve reducing to 400mg or 200mg
Method of Administration:
  1. Take orally once daily, preferably on an empty stomach (at least 1 hour before or 2 hours after eating)
  2. Swallow the tablet whole with water
  3. Do not crush or split the tablet
Precautions:
  1. Avoid during pregnancy and breastfeeding
  2. Monitor blood pressure, liver function, and heart rhythm (ECG)
  3. Avoid grapefruit juice – can increase drug levels
  4. Inform the doctor of any planned surgery
  5. Use with caution in patients with cardiovascular diseases
  6. Avoid driving or operating heavy machinery if experiencing dizziness or fatigue
Drug Interactions:
  1. Avoid CYP3A4 inhibitors like ketoconazole, ritonavir
  2. Avoid CYP3A4 inducers like rifampin, carbamazepine
  3. Caution with anticoagulants like warfarin
  4. Interacts with drugs that prolong QT interval
  5. Inform doctor about all supplements or herbal products
Allergies:
  1. Not suitable for those allergic to Pazopanib or tablet ingredients
  2. Allergic reactions may include rash, swelling, difficulty breathing, dizziness
Overdose Information:
  1. Symptoms: Severe nausea, vomiting, fatigue, elevated liver enzymes, or heart issues
  2. Seek immediate medical attention
  3. No specific antidote; supportive treatment will be provided
Missed Dose Instructions:
  1. If missed and less than 12 hours have passed, take it as soon as possible
  2. If more than 12 hours have passed, skip the missed dose
  3. Do not double dose to make up for a missed tablet
Additional Notes:
  1. Monitor liver enzymes and blood pressure regularly
  2. Patients should notify their doctor of new symptoms or side effects
  3. May affect fertility
  4. Use effective contraception during and after treatment (for both men and women)
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