Product Introduction:
Celdaz 200mg contains Dacarbazine, a potent chemotherapy drug used to treat various cancers, especially melanoma and Hodgkin’s lymphoma. It is an intravenous (IV) injection administered under medical supervision, often as part of combination chemotherapy.
Uses of Celdaz 200mg
Celdaz is used in the treatment of:
-
Metastatic Malignant Melanoma – Used to treat advanced skin cancer.
-
Hodgkin’s Lymphoma – Often used in combination chemotherapy (ABVD regimen).
-
Soft Tissue Sarcomas – Such as leiomyosarcoma and rhabdomyosarcoma.
-
Neuroblastoma – A type of cancer that occurs in nerve tissue.
-
Pancreatic Neuroendocrine Tumors – Sometimes used off-label for rare tumors.
✅ Effective in slowing or stopping the growth of rapidly dividing cancer cells.
How Celdaz Works (Mechanism of Action):
-
Alkylating Agent: Attacks and damages DNA, preventing cancer cells from multiplying.
-
Prodrug: Converts to active metabolites in the liver, enhancing its effectiveness.
-
Cell Cycle-Specific: Works in the S-phase (DNA synthesis phase) of the cell cycle.
🔬 It prevents DNA replication, leading to cell death in rapidly dividing cancer cells.
Dosage of Celdaz 200mg
Typical Recommended Dose:
Dosage varies depending on cancer type and patient condition:
-
Metastatic Melanoma: 2-4.5 mg/kg IV per day for 10 days, every 4 weeks
-
Hodgkin’s Lymphoma: 150 mg/m² IV per day for 5 days, every 4 weeks (as part of ABVD regimen)
-
Soft Tissue Sarcomas: 250 mg/m² IV daily for 5 days, every 3 weeks
⚠️ Dose adjustments may be needed for kidney/liver impairment.
Method of Administration (How to Take It)
-
Administered via slow IV infusion under medical supervision.
-
Often combined with anti-nausea medications to reduce vomiting.
-
Requires careful dosing and hydration to minimize side effects.
💡 Tip: Blood tests are required before each cycle to monitor white blood cell counts.
Side Effects of Celdaz 200mg
Common Side Effects:
-
Nausea & Vomiting (Severe in Some Cases)
-
Loss of Appetite & Weight Loss
-
Fatigue & Weakness
-
Low Blood Cell Counts (Leukopenia, Anemia, Thrombocytopenia)
-
Flu-like Symptoms (Fever, Chills, Muscle Pain)
Serious Side Effects (Seek Medical Help):
-
Severe Bone Marrow Suppression: Leads to anemia, infections, and bleeding.
-
Liver Toxicity (Hepatotoxicity): May cause jaundice and liver enzyme abnormalities.
-
Severe Allergic Reactions: Rash, breathing difficulty, swelling of face/throat.
-
Kidney Damage: Increased creatinine levels and decreased urine output.
🚨 Immediate medical attention is needed for liver toxicity, severe infections, or allergic reactions.
Precautions Before Taking Celdaz
-
Monitor Kidney and Liver Function: Dose adjustments may be needed for impaired function.
-
Stay Hydrated: Helps flush out toxic metabolites and reduces kidney damage.
-
Regular Blood Tests: To monitor white blood cell count and liver enzymes.
-
Avoid Pregnancy & Breastfeeding: Can cause severe birth defects.
-
Use Effective Contraception: Both men and women should use contraception during and after treatment.
-
Avoid Alcohol & Hepatotoxic Drugs: Increases the risk of liver toxicity.
-
Avoid Live Vaccines: Risk of severe infections due to weakened immunity.
⚠️ Patients should report any unusual bleeding, jaundice, or flu-like symptoms immediately.
Drug Interactions (Medications That May Interact)
Celdaz 200mg may interact with:
-
Phenytoin (Seizure Medication): Reduces effectiveness of Dacarbazine.
-
Warfarin (Blood Thinner): Increases risk of bleeding.
-
Live Vaccines (MMR, Polio, Yellow Fever): Can cause severe infections.
-
NSAIDs (Ibuprofen, Naproxen): May worsen kidney toxicity.
-
Other Chemotherapy Agents (Cisplatin, Vinblastine): May increase toxicity.
⚠️ Doctors should adjust doses when combining with other immunosuppressive drugs.
Allergy Warnings
-
Do not take if allergic to Dacarbazine or other alkylating agents.
-
Symptoms of an allergic reaction:
-
Severe rash or itching
-
Swelling of the face or throat
-
Breathing difficulty
🚨 Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
-
Store below 25°C (Room Temperature).
-
Keep away from light and moisture.
-
Once reconstituted, use immediately or store as per medical guidelines.
-
Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
-
Severe Bone Marrow Suppression (Risk of life-threatening infections).
-
Liver Failure (Severe Jaundice, Abnormal Liver Enzymes).
-
Extreme Fatigue & Weakness.
-
Flu-like Symptoms (High Fever, Chills, Muscle Pain).
What to Do in Case of Overdose?
-
Seek immediate medical attention.
-
Emergency supportive care, including IV fluids and blood transfusions, may be required.
-
Liver function tests and dialysis may be needed in severe toxicity.
Missed Dose Instructions
-
If a dose is missed, consult your doctor immediately.
-
Do not take a double dose.
-
Continue with the regular chemotherapy schedule as advised.
Product Introduction:
Celdaz 200mg contains Dacarbazine, a potent chemotherapy drug used to treat various cancers, especially melanoma and Hodgkin’s lymphoma. It is an intravenous (IV) injection administered under medical supervision, often as part of combination chemotherapy.
Uses of Celdaz 200mg
Celdaz is used in the treatment of:
-
Metastatic Malignant Melanoma – Used to treat advanced skin cancer.
-
Hodgkin’s Lymphoma – Often used in combination chemotherapy (ABVD regimen).
-
Soft Tissue Sarcomas – Such as leiomyosarcoma and rhabdomyosarcoma.
-
Neuroblastoma – A type of cancer that occurs in nerve tissue.
-
Pancreatic Neuroendocrine Tumors – Sometimes used off-label for rare tumors.
✅ Effective in slowing or stopping the growth of rapidly dividing cancer cells.
How Celdaz Works (Mechanism of Action):
-
Alkylating Agent: Attacks and damages DNA, preventing cancer cells from multiplying.
-
Prodrug: Converts to active metabolites in the liver, enhancing its effectiveness.
-
Cell Cycle-Specific: Works in the S-phase (DNA synthesis phase) of the cell cycle.
🔬 It prevents DNA replication, leading to cell death in rapidly dividing cancer cells.
Dosage of Celdaz 200mg
Typical Recommended Dose:
Dosage varies depending on cancer type and patient condition:
-
Metastatic Melanoma: 2-4.5 mg/kg IV per day for 10 days, every 4 weeks
-
Hodgkin’s Lymphoma: 150 mg/m² IV per day for 5 days, every 4 weeks (as part of ABVD regimen)
-
Soft Tissue Sarcomas: 250 mg/m² IV daily for 5 days, every 3 weeks
⚠️ Dose adjustments may be needed for kidney/liver impairment.
Method of Administration (How to Take It)
-
Administered via slow IV infusion under medical supervision.
-
Often combined with anti-nausea medications to reduce vomiting.
-
Requires careful dosing and hydration to minimize side effects.
💡 Tip: Blood tests are required before each cycle to monitor white blood cell counts.
Side Effects of Celdaz 200mg
Common Side Effects:
-
Nausea & Vomiting (Severe in Some Cases)
-
Loss of Appetite & Weight Loss
-
Fatigue & Weakness
-
Low Blood Cell Counts (Leukopenia, Anemia, Thrombocytopenia)
-
Flu-like Symptoms (Fever, Chills, Muscle Pain)
Serious Side Effects (Seek Medical Help):
-
Severe Bone Marrow Suppression: Leads to anemia, infections, and bleeding.
-
Liver Toxicity (Hepatotoxicity): May cause jaundice and liver enzyme abnormalities.
-
Severe Allergic Reactions: Rash, breathing difficulty, swelling of face/throat.
-
Kidney Damage: Increased creatinine levels and decreased urine output.
🚨 Immediate medical attention is needed for liver toxicity, severe infections, or allergic reactions.
Precautions Before Taking Celdaz
-
Monitor Kidney and Liver Function: Dose adjustments may be needed for impaired function.
-
Stay Hydrated: Helps flush out toxic metabolites and reduces kidney damage.
-
Regular Blood Tests: To monitor white blood cell count and liver enzymes.
-
Avoid Pregnancy & Breastfeeding: Can cause severe birth defects.
-
Use Effective Contraception: Both men and women should use contraception during and after treatment.
-
Avoid Alcohol & Hepatotoxic Drugs: Increases the risk of liver toxicity.
-
Avoid Live Vaccines: Risk of severe infections due to weakened immunity.
⚠️ Patients should report any unusual bleeding, jaundice, or flu-like symptoms immediately.
Drug Interactions (Medications That May Interact)
Celdaz 200mg may interact with:
-
Phenytoin (Seizure Medication): Reduces effectiveness of Dacarbazine.
-
Warfarin (Blood Thinner): Increases risk of bleeding.
-
Live Vaccines (MMR, Polio, Yellow Fever): Can cause severe infections.
-
NSAIDs (Ibuprofen, Naproxen): May worsen kidney toxicity.
-
Other Chemotherapy Agents (Cisplatin, Vinblastine): May increase toxicity.
⚠️ Doctors should adjust doses when combining with other immunosuppressive drugs.
Allergy Warnings
-
Do not take if allergic to Dacarbazine or other alkylating agents.
-
Symptoms of an allergic reaction:
-
Severe rash or itching
-
Swelling of the face or throat
-
Breathing difficulty
🚨 Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
-
Store below 25°C (Room Temperature).
-
Keep away from light and moisture.
-
Once reconstituted, use immediately or store as per medical guidelines.
-
Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
-
Severe Bone Marrow Suppression (Risk of life-threatening infections).
-
Liver Failure (Severe Jaundice, Abnormal Liver Enzymes).
-
Extreme Fatigue & Weakness.
-
Flu-like Symptoms (High Fever, Chills, Muscle Pain).
What to Do in Case of Overdose?
-
Seek immediate medical attention.
-
Emergency supportive care, including IV fluids and blood transfusions, may be required.
-
Liver function tests and dialysis may be needed in severe toxicity.
Missed Dose Instructions
-
If a dose is missed, consult your doctor immediately.
-
Do not take a double dose.
-
Continue with the regular chemotherapy schedule as advised.
