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Ciszest 50mg - Clsplatin Injection

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Ciszest 50mg - Clsplatin Injection

Ciszest 50mg (Cisplatin Injection) is a platinum-based chemotherapy drug used to treat various types of cancers, including testicular, ovarian, bladder, lung, and head & neck cancers. It works by interfering with the DNA of cancer cells, preventing their growth and division.

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Description Product Details
General Information:
Generic Name: Cisplatin
Brand Name: Ciszest
Packing: Vial for intravenous (IV) injection
Strength: 50mg
Manufacturer: [Specify Manufacturer]
Form: Injectable Solution
Category: Platinum-Based Chemotherapy Drug
Product Introduction:
Ciszest 50mg is a potent platinum-containing chemotherapy drug used to destroy rapidly dividing cancer cells. It is typically administered intravenously and is often combined with other chemotherapy agents for enhanced effectiveness.
Uses of Ciszest 50mg
Ciszest is used in the treatment of:
  1. Testicular Cancer: Often used as part of BEP (Bleomycin, Etoposide, Cisplatin) therapy.
  2. Ovarian Cancer: Used in combination with paclitaxel or other drugs.
  3. Bladder Cancer: Administered as part of systemic chemotherapy.
  4. Lung Cancer (Non-Small Cell & Small Cell Lung Cancer): Combined with other agents.
  5. Head and Neck Cancer: Often used with radiation therapy.
  6. Other Solid Tumors: Includes stomach, esophageal, and cervical cancers.
✅ Highly effective in killing cancer cells by damaging their DNA.
How Ciszest Works (Mechanism of Action):
  1. Platinum-Based Cytotoxic Agent: Binds to DNA, causing cross-linking and preventing replication.
  2. Disrupts Cancer Cell Division: Leads to apoptosis (programmed cell death).
  3. Enhances Radiation Therapy Effects: Increases tumor cell sensitivity to radiation.
  4. Works Best in Combination Therapy: Often combined with etoposide, paclitaxel, or 5-FU.
🔬 Stops tumor growth by interfering with DNA synthesis and repair.
Dosage of Ciszest 50mg
Typical Recommended Dose:
Dosage depends on the type of cancer and patient's condition:
  1. Bladder Cancer: 50-70 mg/m² IV infusion every 3-4 weeks.
  2. Testicular Cancer: 20 mg/m² IV infusion for 5 days in combination therapy.
  3. Ovarian Cancer: 75-100 mg/m² IV infusion every 3-4 weeks.
  4. Lung Cancer: 75 mg/m² IV infusion every 3-4 weeks with other chemo agents.
⚠️ Dose modifications required for kidney impairment or severe side effects.
Method of Administration (How to Take It)
  1. Administered ONLY via IV infusion under medical supervision.
  2. Adequate hydration before and after administration is essential to prevent kidney damage.
  3. Given in combination with anti-nausea medications (antiemetics) to reduce vomiting.
  4. Infusion time varies (usually over 1-2 hours).
💡 Tip: Frequent monitoring of kidney function and electrolyte levels is necessary.
Side Effects of Ciszest 50mg
Common Side Effects:
  1. Nausea & Severe Vomiting (very common)
  2. Loss of Appetite & Weight Loss
  3. Fatigue & Weakness
  4. Hearing Loss (Ototoxicity)
  5. Kidney Damage (Nephrotoxicity)
  6. Hair Loss (Alopecia)
  7. Electrolyte Imbalance (Low Magnesium & Potassium Levels)
Serious Side Effects (Seek Medical Help):
  1. Severe Kidney Failure: Can cause decreased urine output and high creatinine levels.
  2. Hearing Problems (Tinnitus & Hearing Loss): Common in high doses.
  3. Severe Allergic Reactions: Rash, swelling, difficulty breathing.
  4. Peripheral Neuropathy: Numbness, tingling, or weakness in hands/feet.
  5. Bone Marrow Suppression: Increased risk of infections, anemia, and bleeding.
🚨 Immediate medical attention is needed for kidney damage, severe allergic reactions, or hearing loss.
Precautions Before Taking Ciszest
  1. Hydration is Essential: Must drink plenty of fluids before and after treatment.
  2. Kidney Function Monitoring: Regular blood tests required.
  3. Hearing Tests Before Treatment: To check for pre-existing hearing problems.
  4. Use Effective Contraception: Can cause birth defects in unborn babies.
  5. Avoid Live Vaccines: Increased infection risk due to weakened immune system.
⚠️ Patients should report ringing in the ears, reduced urination, or unusual bruising immediately.
Drug Interactions (Medications That May Interact)
Ciszest 50mg may interact with:
  1. Aminoglycoside Antibiotics (e.g., Gentamicin, Amikacin): Increases kidney and ear toxicity.
  2. Loop Diuretics (e.g., Furosemide): Higher risk of hearing loss.
  3. NSAIDs (e.g., Ibuprofen, Naproxen): Increases kidney damage risk.
  4. Other Chemotherapy Agents (e.g., Paclitaxel, 5-FU): Can enhance effectiveness but also increase toxicity.
  5. Radiation Therapy: Increases risk of severe side effects.
⚠️ Doctors should adjust doses when given with other nephrotoxic drugs.
Allergy Warnings
  1. Do not take if allergic to Cisplatin or other platinum-based chemotherapy drugs.
  2. Symptoms of an allergic reaction:
    1. Severe rash or itching
    2. Swelling of the face or throat
    3. Breathing difficulty
🚨 Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
  1. Store at 15-25°C (Room Temperature).
  2. Protect from light and moisture.
  3. Do not freeze.
  4. Once diluted, use immediately or store under refrigeration as per guidelines.
Overdose Information
Symptoms of Overdose:
  1. Severe Kidney Failure (No urine output, swelling, confusion).
  2. Complete Hearing Loss or Tinnitus.
  3. Extreme Nausea & Vomiting.
  4. Profound Bone Marrow Suppression (High infection risk, bleeding).
What to Do in Case of Overdose?
  1. Seek immediate medical attention.
  2. Dialysis may be required in severe kidney failure cases.
  3. Supportive treatment, hydration, and electrolyte correction are crucial.
Missed Dose Instructions
  1. If a dose is missed, consult your doctor immediately.
  2. Do not take a double dose.
  3. Continue with the regular chemotherapy schedule as advised.

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