Femistra 1mg - Anastrozole Tablets

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1. Hormone Receptor-Positive Breast Cancer – Slows tumor growth in postmenopausal women.
2. Adjuvant Therapy for Early Breast Cancer – Used after surgery to prevent recurrence.
3. Metastatic Breast Cancer – Helps manage advanced-stage breast cancer.
4. Neoadjuvant Therapy – Used before surgery to shrink tumors.
5. Breast Cancer Prevention – Sometimes prescribed to high-risk women to reduce cancer risk.

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1. Anastrozole inhibits the aromatase enzyme, preventing the conversion of androgens into estrogen.
2. Lowering estrogen levels deprives hormone-sensitive tumors of their growth signal, leading to tumor shrinkage or slowed progression.
3. This medication is effective only in postmenopausal women, as their primary estrogen production occurs in peripheral tissues.

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1. Standard dose: 1 mg once daily.
2. Treatment duration: Usually 5 years, but may be adjusted based on medical evaluation.
3. Dosage adjustments: Not typically needed unless severe side effects occur.

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Method of Administration (How to Take It)

1. Can be taken with or without food.
2. Swallow the tablet whole with water—do not crush, chew, or break it.
3. Take at the same time every day for consistency.
4. If vomiting occurs after taking the dose, do not retake it—wait for the next scheduled dose.

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1. Hot flashes
2. Joint pain and stiffness
3. Fatigue and weakness
4. Osteoporosis (bone thinning, increased fracture risk)
5. Headache and dizziness
6. Nausea and vomiting

1. Severe osteoporosis leading to fractures
2. Heart problems (chest pain, shortness of breath, irregular heartbeat)
3. Liver damage (jaundice, dark urine, stomach pain)
4. Blood clots (sudden numbness, vision changes, difficulty speaking)
5. Severe allergic reactions (rash, swelling, breathing problems)

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1. Pregnancy & Breastfeeding: Not safe—can cause harm to the baby.
2. Bone Health: Increases risk of osteoporosis—calcium and vitamin D supplements may be needed.
3. Heart Conditions: May raise the risk of heart disease or high cholesterol.
4. Liver or Kidney Disease: Requires dose adjustment or close monitoring.
5. Drowsiness or Dizziness: Avoid activities like driving if affected.

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1. Tamoxifen – Reduces the effectiveness of Anastrozole.
2. Estrogen Therapies (HRT, birth control pills) – Counteracts the drug’s effect.
3. Blood Thinners (Warfarin, Aspirin, Heparin) – Increases bleeding risk.
4. Rifampin & Carbamazepine – May lower Anastrozole levels, reducing effectiveness.
5. Corticosteroids – Can increase the risk of osteoporosis.

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1. Do not take Femistra if allergic to Anastrozole or its ingredients.
2. Signs of an allergic reaction:
   1. Swelling of face, lips, or throat
   2. Difficulty breathing
   3. Severe rash or itching
   4. Dizziness or fainting

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1. Store at room temperature (15°C - 30°C / 59°F - 86°F).
2. Keep in original packaging to protect from moisture and light.
3. Keep away from children and pets.

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1. Severe nausea and vomiting
2. Dizziness or fainting
3. Liver or kidney damage symptoms (yellow skin, confusion)
4. Severe weakness or drowsiness

1. Seek immediate medical attention.
2. Hospitalization may be required for supportive care.

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1. If missed by less than 12 hours: Take the dose as soon as possible.
2. If missed by more than 12 hours: Skip the missed dose and take the next scheduled dose.
3. Do not take a double dose to make up for a missed one.