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Ab-Sun 250mg - Abiraterone Acetate Tablets

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Ab-Sun 250mg - Abiraterone Acetate Tablets

AB-SUN 250mg is an antibiotic capsule containing Azithromycin 250mg, used to treat bacterial infections like respiratory, skin, and ear infections. It helps stop the growth of bacteria and provides quick relief from infection symptoms.

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Description Product Details
General Information:
Generic Name: Abiraterone Acetate
Brand Name: Ab-Sun
Packing: Typically available in bottles of 120 tablets
Strength: 250 mg per tablet
Manufacturer: Bruck Pharma Private Limited
Company: Sunlight Lifescience
Form: Tablet
Category: Anti-cancer drug (Androgen Biosynthesis Inhibitor)
Product Introduction:
Ab-Sun 250mg is a prescription medication used in the treatment of advanced prostate cancer, specifically metastatic castration-resistant prostate cancer (mCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC). It functions by reducing androgen (testosterone) production, which slows the progression of prostate cancer. It is usually prescribed in combination with prednisone or prednisolone to minimize certain side effects.
Uses:
Ab-Sun 250mg is prescribed for:
  1. Metastatic Castration-Resistant Prostate Cancer (mCRPC): Advanced prostate cancer that continues to grow despite low testosterone levels.
  2. Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): Newly diagnosed prostate cancer that has spread but still responds to hormonal treatment.
  3. Lowering Prostate-Specific Antigen (PSA) Levels: Helps control cancer progression by reducing PSA levels.
  4. Slowing Tumor Growth: Extends survival and delays disease progression.
  5. Relieving Symptoms of Advanced Prostate Cancer: Helps with pain relief, urinary symptoms, and overall quality of life.
  6. Combination with Prednisone: Used to reduce side effects like high blood pressure and fluid retention.
How It Works (Mechanism of Action):
Ab-Sun 250mg contains Abiraterone Acetate, a CYP17 enzyme inhibitor.
  1. The CYP17 enzyme plays a key role in the production of androgens (testosterone and related hormones).
  2. Prostate cancer cells depend on androgens for growth.
  3. Abiraterone blocks CYP17, leading to a significant reduction in androgen production from:
    1. Testes
    2. Adrenal glands
    3. Tumor cells
  4. This results in tumor shrinkage and slows down cancer progression.
Dosage:
  1. Recommended dose: 1,000 mg per day (4 tablets of 250 mg each)
  2. Taken once daily on an empty stomach (at least 1 hour before or 2 hours after meals).
  3. Must be taken with prednisone (5 mg twice daily) to reduce side effects.
Always follow your doctor’s prescription carefully.
Method of Administration:
  1. Swallow the tablets whole with a glass of water.
  2. Do not crush, chew, or break the tablets.
  3. Take on an empty stomach (food increases absorption and side effects).
  4. Avoid grapefruit juice, as it may interfere with the drug’s metabolism.
  5. Take at the same time every day for consistency.
Side Effects:
Common Side Effects:
  1. High blood pressure (Hypertension)
  2. Low potassium levels (Hypokalemia) – Can cause muscle weakness or cramps.
  3. Swelling in the legs & feet (Edema, Fluid retention)
  4. Liver enzyme elevation (Hepatotoxicity)
  5. Increased cholesterol & triglycerides
  6. Joint or muscle pain
  7. Fatigue, dizziness, headache
Severe Side Effects:
  1. Heart problems (Irregular heartbeat, chest pain, heart failure)
  2. Liver damage (Hepatitis, liver failure) – Symptoms include yellowing of the skin/eyes and dark urine.
  3. Severe low potassium levels – Can lead to irregular heartbeat and muscle paralysis.
  4. Adrenal insufficiency – The body may stop producing enough cortisol.
  5. Severe allergic reactions – Rash, swelling of the face/tongue, difficulty breathing.
Precautions:
  1. Not for use in women or children.
  2. Avoid alcohol, as it can worsen liver damage.
  3. Monitor blood pressure and potassium levels regularly.
  4. Patients with diabetes should be careful, as this drug may increase blood sugar levels.
  5. People with liver disease or heart problems require close monitoring.
  6. Elderly patients may be more prone to side effects.
Drug Interactions:
Avoid taking Ab-Sun 250mg with:
  1. Rifampin, Phenytoin, Carbamazepine – May reduce effectiveness.
  2. Ketoconazole, Itraconazole, Clarithromycin – Can increase drug toxicity.
  3. Warfarin & Blood Thinners – Increases bleeding risk.
  4. Diuretics (Furosemide, Spironolactone) – May worsen potassium imbalances.
  5. HIV medications (Ritonavir, Efavirenz) – May alter drug levels in the body.
  6. Heart medications (Digoxin, Diltiazem, Verapamil) – Requires close monitoring.
Allergies:
  1. Do not take Ab-Sun 250mg if you are allergic to Abiraterone Acetate or any of its ingredients.
  2. Symptoms of an allergic reaction include rash, itching, swelling of the face, severe dizziness, or difficulty breathing.
Storage Instructions:
  1. Store at room temperature (20-25°C / 68-77°F)
  2. Keep away from moisture and direct sunlight.
  3. Store in original container with the lid tightly closed.
  4. Keep out of reach of children.
Overdose Information:
Symptoms of Overdose:
  1. Severe high blood pressure
  2. Extreme weakness or confusion
  3. Signs of liver damage (yellow skin, dark urine)
  4. Dangerously low potassium levels (irregular heartbeat, muscle weakness)
What to Do in Case of Overdose?
  1. Seek immediate medical attention.
  2. Contact a poison control center or go to the nearest hospital.
  3. Bring the medicine bottle for reference.
Missed Dose Instructions:
  1. If you miss a dose, take it as soon as you remember, unless it is close to the next dose.
  2. Do not take two doses at the same time to compensate for a missed dose.
  3. Continue with your regular dosing schedule.
Additional Notes:
  1. Men taking Ab-Sun should use contraception if their partner is pregnant or may become pregnant.
  2. Do not donate blood while on this medication, as it may harm recipients.
  3. Regular liver function tests (LFTs) are necessary to check for toxicity.
  4. This medicine does not cure prostate cancer, but it helps control the disease and improve survival rates.
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