Product Introduction:
Abitate U 250mg is a prescription medication used to treat advanced prostate cancer, specifically metastatic castration-resistant prostate cancer (mCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC). It works by blocking testosterone production, which slows the growth of prostate cancer cells. This medication is usually taken in combination with prednisone or prednisolone to reduce potential side effects.
Uses:
Abitate U 250mg is prescribed for:
-
Metastatic Castration-Resistant Prostate Cancer (mCRPC): Prostate cancer that continues to grow despite low testosterone levels.
-
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): Newly diagnosed prostate cancer that has spread but still responds to hormonal treatment.
-
Reduction of Prostate-Specific Antigen (PSA) Levels: Helps in controlling prostate cancer progression.
-
Delaying Cancer Progression: Extends survival and improves quality of life in advanced cancer cases.
-
Relief from Cancer-Related Symptoms: Reduces pain, urinary difficulties, and other complications of prostate cancer.
-
Used with Prednisone: To help manage side effects such as fluid retention and high blood pressure.
How It Works (Mechanism of Action):
Abitate U 250mg contains Abiraterone Acetate, which is a CYP17 enzyme inhibitor.
- CYP17 enzyme is essential for producing androgens (testosterone and related hormones).
- Prostate cancer cells rely on androgens for growth.
- Abiraterone blocks CYP17, which significantly reduces androgen levels in:
- Testes
- Adrenal glands
- Tumor cells
- This leads to tumor shrinkage and slows the progression of prostate cancer.
Dosage:
- Recommended dose: 1,000 mg per day (4 tablets of 250 mg each)
- Taken once daily on an empty stomach (1 hour before or 2 hours after a meal).
- Must be taken with prednisone (5 mg twice daily) to manage side effects.
Always follow your doctor’s prescription carefully.
Method of Administration:
- Swallow the tablets whole with a glass of water.
- Do not crush, chew, or break the tablets.
- Take on an empty stomach (food increases the absorption and side effects).
- Avoid grapefruit juice, as it can interfere with drug metabolism.
- Take at the same time each day for better effectiveness.
Side Effects:
Common Side Effects:
- High blood pressure (Hypertension)
- Low potassium levels (Hypokalemia) – Can cause muscle weakness or cramps.
- Swelling in the legs & feet (Edema, Fluid retention)
- Liver function abnormalities (Elevated liver enzymes, Hepatotoxicity)
- Increased cholesterol & triglycerides
- Joint or muscle pain
- Fatigue, dizziness, headache
Severe Side Effects:
- Heart problems (Irregular heartbeat, chest pain, heart failure)
- Severe liver damage (Hepatitis, liver failure) – Symptoms include yellowing of the skin/eyes, dark urine.
- Dangerously low potassium levels – Can lead to irregular heartbeat, muscle paralysis.
- Adrenal insufficiency – The body may stop producing enough cortisol.
- Severe allergic reactions – Rash, swelling of the face/tongue, difficulty breathing.
Precautions:
- Not for use in women or children.
- Avoid alcohol, as it can increase liver damage.
- Regular blood pressure and potassium monitoring is essential.
- Patients with diabetes should be cautious, as this drug may raise blood sugar levels.
- People with liver disease or heart problems require close monitoring.
- Elderly patients may be more prone to side effects.
Drug Interactions:
Avoid taking Abitate U 250mg with:
- Rifampin, Phenytoin, Carbamazepine – May decrease drug effectiveness.
- Ketoconazole, Itraconazole, Clarithromycin – Can increase drug toxicity.
- Warfarin & Blood Thinners – Increases bleeding risk.
- Diuretics (Furosemide, Spironolactone) – Can worsen potassium imbalances.
- HIV medications (Ritonavir, Efavirenz) – May alter drug levels in the body.
- Heart medications (Digoxin, Verapamil, Diltiazem) – Requires careful monitoring.
Allergies:
-
Do not take Abitate U 250mg if you are allergic to Abiraterone Acetate or any of its ingredients.
-
Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or breathing difficulties.
Storage Instructions:
- Store at room temperature (20-25°C / 68-77°F)
- Keep away from moisture and direct sunlight.
- Store in original container with the lid tightly closed.
- Keep out of reach of children.
Overdose Information:
Symptoms of Overdose:
- Severe high blood pressure
- Extreme weakness or confusion
- Signs of liver damage (yellow skin, dark urine)
- Dangerously low potassium levels (irregular heartbeat, muscle weakness)
What to Do in Case of Overdose?
- Seek immediate medical attention.
- Contact a poison control center or go to the nearest hospital.
- Bring the medicine bottle for reference.
Missed Dose Instructions:
- If you miss a dose, take it as soon as you remember, unless it is close to the next dose.
- Do not take two doses at the same time to compensate for a missed dose.
- Continue with your regular dosing schedule.
Additional Notes:
- Men taking Abitate U should use contraception if their partner is pregnant or may become pregnant.
- Do not donate blood while on this medication, as it can harm recipients.
- Regular liver function tests (LFTs) are necessary to check for toxicity.
- This medicine does not cure prostate cancer, but it helps control the disease and improve survival rates.
Product Introduction:
Abitate U 250mg is a prescription medication used to treat advanced prostate cancer, specifically metastatic castration-resistant prostate cancer (mCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC). It works by blocking testosterone production, which slows the growth of prostate cancer cells. This medication is usually taken in combination with prednisone or prednisolone to reduce potential side effects.
Uses:
Abitate U 250mg is prescribed for:
-
Metastatic Castration-Resistant Prostate Cancer (mCRPC): Prostate cancer that continues to grow despite low testosterone levels.
-
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): Newly diagnosed prostate cancer that has spread but still responds to hormonal treatment.
-
Reduction of Prostate-Specific Antigen (PSA) Levels: Helps in controlling prostate cancer progression.
-
Delaying Cancer Progression: Extends survival and improves quality of life in advanced cancer cases.
-
Relief from Cancer-Related Symptoms: Reduces pain, urinary difficulties, and other complications of prostate cancer.
-
Used with Prednisone: To help manage side effects such as fluid retention and high blood pressure.
How It Works (Mechanism of Action):
Abitate U 250mg contains Abiraterone Acetate, which is a CYP17 enzyme inhibitor.
- CYP17 enzyme is essential for producing androgens (testosterone and related hormones).
- Prostate cancer cells rely on androgens for growth.
- Abiraterone blocks CYP17, which significantly reduces androgen levels in:
- Testes
- Adrenal glands
- Tumor cells
- This leads to tumor shrinkage and slows the progression of prostate cancer.
Dosage:
- Recommended dose: 1,000 mg per day (4 tablets of 250 mg each)
- Taken once daily on an empty stomach (1 hour before or 2 hours after a meal).
- Must be taken with prednisone (5 mg twice daily) to manage side effects.
Always follow your doctor’s prescription carefully.
Method of Administration:
- Swallow the tablets whole with a glass of water.
- Do not crush, chew, or break the tablets.
- Take on an empty stomach (food increases the absorption and side effects).
- Avoid grapefruit juice, as it can interfere with drug metabolism.
- Take at the same time each day for better effectiveness.
Side Effects:
Common Side Effects:
- High blood pressure (Hypertension)
- Low potassium levels (Hypokalemia) – Can cause muscle weakness or cramps.
- Swelling in the legs & feet (Edema, Fluid retention)
- Liver function abnormalities (Elevated liver enzymes, Hepatotoxicity)
- Increased cholesterol & triglycerides
- Joint or muscle pain
- Fatigue, dizziness, headache
Severe Side Effects:
- Heart problems (Irregular heartbeat, chest pain, heart failure)
- Severe liver damage (Hepatitis, liver failure) – Symptoms include yellowing of the skin/eyes, dark urine.
- Dangerously low potassium levels – Can lead to irregular heartbeat, muscle paralysis.
- Adrenal insufficiency – The body may stop producing enough cortisol.
- Severe allergic reactions – Rash, swelling of the face/tongue, difficulty breathing.
Precautions:
- Not for use in women or children.
- Avoid alcohol, as it can increase liver damage.
- Regular blood pressure and potassium monitoring is essential.
- Patients with diabetes should be cautious, as this drug may raise blood sugar levels.
- People with liver disease or heart problems require close monitoring.
- Elderly patients may be more prone to side effects.
Drug Interactions:
Avoid taking Abitate U 250mg with:
- Rifampin, Phenytoin, Carbamazepine – May decrease drug effectiveness.
- Ketoconazole, Itraconazole, Clarithromycin – Can increase drug toxicity.
- Warfarin & Blood Thinners – Increases bleeding risk.
- Diuretics (Furosemide, Spironolactone) – Can worsen potassium imbalances.
- HIV medications (Ritonavir, Efavirenz) – May alter drug levels in the body.
- Heart medications (Digoxin, Verapamil, Diltiazem) – Requires careful monitoring.
Allergies:
-
Do not take Abitate U 250mg if you are allergic to Abiraterone Acetate or any of its ingredients.
-
Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or breathing difficulties.
Storage Instructions:
- Store at room temperature (20-25°C / 68-77°F)
- Keep away from moisture and direct sunlight.
- Store in original container with the lid tightly closed.
- Keep out of reach of children.
Overdose Information:
Symptoms of Overdose:
- Severe high blood pressure
- Extreme weakness or confusion
- Signs of liver damage (yellow skin, dark urine)
- Dangerously low potassium levels (irregular heartbeat, muscle weakness)
What to Do in Case of Overdose?
- Seek immediate medical attention.
- Contact a poison control center or go to the nearest hospital.
- Bring the medicine bottle for reference.
Missed Dose Instructions:
- If you miss a dose, take it as soon as you remember, unless it is close to the next dose.
- Do not take two doses at the same time to compensate for a missed dose.
- Continue with your regular dosing schedule.
Additional Notes:
- Men taking Abitate U should use contraception if their partner is pregnant or may become pregnant.
- Do not donate blood while on this medication, as it can harm recipients.
- Regular liver function tests (LFTs) are necessary to check for toxicity.
- This medicine does not cure prostate cancer, but it helps control the disease and improve survival rates.
