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Erlozest 150mg - Erlotinib Tablets

Erlozest 150mg is an oral anticancer medication containing Erlotinib, primarily used to treat non-small cell lung cancer (NSCLC) and pancreatic cancer. It functions by inhibiting the epidermal growth factor receptor (EGFR), thereby hindering cancer cell proliferation.

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Description Product Details

General Information:

Generic Name: Erlotinib

Brand Name: Erlozest

Packaging: Box containing 30 tablets

Strength: 150mg per tablet

Manufacturer: Zee Laboratories Ltd

Form: Oral tablets

Category: Antineoplastic Agent / Tyrosine Kinase Inhibitor

Product Introduction:

Erlozest 150mg is a targeted therapy developed by Zee Laboratories Ltd. It is specifically formulated to address cancers associated with EGFR mutations, offering a personalized approach to cancer treatment.

Uses:

Non-Small Cell Lung Cancer (NSCLC): For patients with locally advanced or metastatic NSCLC with confirmed EGFR mutations.
Pancreatic Cancer: In combination with gemcitabine for the treatment of advanced pancreatic cancer.

Storage Instructions:

Store at 15°C to 30°C.
Protect from moisture, heat, and direct sunlight.
Keep in the original packaging.
Ensure it is out of reach of children and pets.

How It Works (Mechanism of Action):

Erlotinib targets and inhibits the EGFR tyrosine kinase, a protein that plays a crucial role in the growth and spread of cancer cells. By blocking this receptor, Erlotinib disrupts cancer cell signaling pathways, leading to reduced tumor growth and progression.

Side Effects:

Common Side Effects:

Rash and dry skin
Diarrhea
Nausea and vomiting
Fatigue
Loss of appetite
Weight loss

Serious Side Effects:

Interstitial Lung Disease (ILD): Characterized by sudden breathing difficulties, cough, and fever. Seek immediate medical attention if these occur.
Liver Toxicity: Monitor for signs such as yellowing of the skin or eyes, dark urine, or persistent nausea.
Gastrointestinal Perforation: Severe abdominal pain could indicate this rare but serious condition.
Severe Skin Reactions: Including blistering or peeling.
Ocular Disorders: Such as eye pain or vision changes.

Dosage (Typical Recommended Dose):

NSCLC: 150mg taken orally once daily.
Pancreatic Cancer: 100mg taken orally once daily in combination with gemcitabine.

Dosage adjustments may be necessary based on individual response and the occurrence of adverse effects.

Method of Administration:

Take on an empty stomach, at least 1 hour before or 2 hours after eating.
Swallow the tablet whole with a glass of water; do not crush or chew.
Maintain a consistent daily schedule for taking the medication.

Precautions:

Smoking: Avoid smoking, as it can decrease the effectiveness of the medication.
Sun Exposure: Use sunscreen and wear protective clothing to minimize skin reactions.
Pregnancy and Breastfeeding: Not recommended during pregnancy or while breastfeeding. Effective contraception should be used during treatment and for at least 2 weeks after the final dose.
Liver and Kidney Function: Regular monitoring is advised due to potential toxicity.

Drug Interactions:

CYP3A4 Inhibitors (e.g., ketoconazole): May increase Erlotinib levels, raising the risk of toxicity.
CYP3A4 Inducers (e.g., rifampicin): May decrease Erlotinib levels, reducing efficacy.
Proton Pump Inhibitors (e.g., omeprazole): Can reduce the absorption of Erlotinib; concomitant use should be avoided.
Anticoagulants (e.g., warfarin): Increased risk of bleeding; monitor INR levels closely.

Allergies:

Contraindicated in patients with known hypersensitivity to Erlotinib or any of its components.
Seek immediate medical attention if signs of an allergic reaction occur, such as difficulty breathing, swelling, or severe rash.

Overdose Information:

Symptoms: Severe rash, diarrhea, liver dysfunction.
Management: Provide supportive care; there is no specific antidote.
Action: Contact a healthcare provider or emergency services immediately if an overdose is suspected.

Missed Dose Instructions:

If a dose is missed, take it as soon as remembered, provided it is at least 12 hours before the next scheduled dose.
If less than 12 hours remain before the next dose, skip the missed dose and resume the regular dosing schedule.
Do not double the dose to make up for a missed one.

Additional Notes:

Regular follow-up appointments are essential to monitor treatment response and manage side effects.
Maintain adequate hydration and nutrition during therapy.

Product Introduction:

Uses:

Non-Small Cell Lung Cancer (NSCLC): For patients with locally advanced or metastatic NSCLC with confirmed EGFR mutations.
Pancreatic Cancer: In combination with gemcitabine for the treatment of advanced pancreatic cancer.

Storage Instructions:

Store at 15°C to 30°C.
Protect from moisture, heat, and direct sunlight.
Keep in the original packaging.
Ensure it is out of reach of children and pets.

How It Works (Mechanism of Action):

Side Effects:

Common Side Effects:

Rash and dry skin
Diarrhea
Nausea and vomiting
Fatigue
Loss of appetite
Weight loss

Serious Side Effects:

Interstitial Lung Disease (ILD): Characterized by sudden breathing difficulties, cough, and fever. Seek immediate medical attention if these occur.
Liver Toxicity: Monitor for signs such as yellowing of the skin or eyes, dark urine, or persistent nausea.
Gastrointestinal Perforation: Severe abdominal pain could indicate this rare but serious condition.
Severe Skin Reactions: Including blistering or peeling.
Ocular Disorders: Such as eye pain or vision changes.

Dosage (Typical Recommended Dose):

NSCLC: 150mg taken orally once daily.
Pancreatic Cancer: 100mg taken orally once daily in combination with gemcitabine.

Dosage adjustments may be necessary based on individual response and the occurrence of adverse effects.

Method of Administration:

Take on an empty stomach, at least 1 hour before or 2 hours after eating.
Swallow the tablet whole with a glass of water; do not crush or chew.
Maintain a consistent daily schedule for taking the medication.

Precautions:

Smoking: Avoid smoking, as it can decrease the effectiveness of the medication.
Sun Exposure: Use sunscreen and wear protective clothing to minimize skin reactions.
Pregnancy and Breastfeeding: Not recommended during pregnancy or while breastfeeding. Effective contraception should be used during treatment and for at least 2 weeks after the final dose.
Liver and Kidney Function: Regular monitoring is advised due to potential toxicity.

Drug Interactions:

CYP3A4 Inhibitors (e.g., ketoconazole): May increase Erlotinib levels, raising the risk of toxicity.
CYP3A4 Inducers (e.g., rifampicin): May decrease Erlotinib levels, reducing efficacy.
Proton Pump Inhibitors (e.g., omeprazole): Can reduce the absorption of Erlotinib; concomitant use should be avoided.
Anticoagulants (e.g., warfarin): Increased risk of bleeding; monitor INR levels closely.

Allergies:

Contraindicated in patients with known hypersensitivity to Erlotinib or any of its components.
Seek immediate medical attention if signs of an allergic reaction occur, such as difficulty breathing, swelling, or severe rash.

Overdose Information:

Symptoms: Severe rash, diarrhea, liver dysfunction.
Management: Provide supportive care; there is no specific antidote.
Action: Contact a healthcare provider or emergency services immediately if an overdose is suspected.

Missed Dose Instructions:

If a dose is missed, take it as soon as remembered, provided it is at least 12 hours before the next scheduled dose.
If less than 12 hours remain before the next dose, skip the missed dose and resume the regular dosing schedule.
Do not double the dose to make up for a missed one.

Additional Notes:

Regular follow-up appointments are essential to monitor treatment response and manage side effects.
Maintain adequate hydration and nutrition during therapy.

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Erlozest 150mg - Erlotinib Tablets

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