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Glioz 100mg - Temozolomide Capsules

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Glioz 100mg - Temozolomide Capsules

Glioz 100mg contains Temozolomide, an oral alkylating agent used to treat certain types of brain tumors such as glioblastoma multiforme (GBM) and anaplastic astrocytoma. It works by damaging cancer cell DNA, preventing replication and causing cell death.

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Description Product Details
General Information:
Generic Name: Temozolomide
Brand Name: Glioz
Packing: Bottle/strip (varies by manufacturer)
Strength: 100 mg
Manufacturer: Dr. Reddy’s Laboratories
Form: Hard gelatin capsule
Category: Alkylating Agent, Antineoplastic, Chemotherapy
Product Intro:
Glioz 100mg is an anti-cancer chemotherapy drug classified under alkylating agents, primarily prescribed for the treatment of malignant brain tumors. It is especially effective when used in combination with radiotherapy for aggressive brain cancers. Its oral formulation provides convenience in outpatient settings.
Uses:
  1. Glioblastoma multiforme (GBM) – newly diagnosed or recurrent
  2. Anaplastic astrocytoma – refractory or relapsed
  3. Brain metastases from other cancers (off-label use)
  4. Combination with radiotherapy in GBM
  5. Maintenance therapy after radiotherapy in brain cancer
  6. Investigational use in melanoma and soft tissue sarcomas
Storage Instructions:
  1. Store at 20°C to 25°C (68°F to 77°F)
  2. Protect from moisture, light, and heat
  3. Keep in original packaging
  4. Keep out of reach of children
How it Works (Mechanism of Action):
Temozolomide is a DNA-alkylating agent. It works by methylating DNA at the O6 and N7 positions of guanine, which leads to DNA strand breaks and apoptosis (programmed cell death). Since cancer cells divide rapidly, they are more susceptible to this damage, leading to tumor shrinkage or slower growth.
Side Effects:
Common Side Effects:
  1. Nausea and vomiting
  2. Fatigue
  3. Loss of appetite
  4. Constipation
  5. Headache
  6. Hair thinning
Severe Side Effects:
  1. Bone marrow suppression (low blood cells: anemia, leukopenia, thrombocytopenia)
  2. Severe infections due to low immunity
  3. Liver toxicity
  4. Pneumocystis jirovecii pneumonia (PCP) – especially in combination with radiotherapy
  5. Hypersensitivity reactions
Dosage (Typical Recommended Dose):
  1. For newly diagnosed GBM:
    75 mg/m² daily during radiation (for 42 days), followed by
    150–200 mg/m² once daily for 5 days in 28-day cycles (maintenance phase)
  2. Dose adjusted based on body surface area (BSA) and tolerance
  3. Always follow oncologist’s protocol
Method of Administration:
  1. Oral administration, swallowed whole with a glass of water
  2. Take on an empty stomach or at least 1 hour before or 2 hours after food
  3. Do not crush or chew the capsules
  4. If vomiting occurs after dose, do not retake—wait until next scheduled dose
Precautions:
  1. Monitor CBC before and during treatment due to risk of bone marrow suppression
  2. Antiemetic medication may be prescribed to manage nausea
  3. Avoid use in pregnant or breastfeeding women
  4. Use effective contraception during treatment and for at least 6 months after
  5. Prophylactic antibiotics may be prescribed to prevent infections (e.g., PCP)
Drug Interactions:
  1. Myelosuppressive agents (e.g., carboplatin, paclitaxel) may enhance toxicity
  2. Avoid live vaccines
  3. Increased risk of infections with corticosteroids
  4. Monitor liver function if co-administered with hepatotoxic drugs
Allergies:
  1. Contraindicated in patients with hypersensitivity to Temozolomide or dacarbazine
  2. Watch for signs like rash, swelling, difficulty breathing, or fever
Overdose Information:
  1. Symptoms: Severe myelosuppression, bleeding, increased risk of infection
  2. Immediate supportive care and hospitalization required
  3. No known specific antidote
Missed Dose Instructions:
  1. Take as soon as remembered on the same day
  2. If the day has passed, skip the missed dose
  3. Do not double the dose
Additional Notes:
  1. Wear gloves when handling capsules if administering to someone else
  2. Regular monitoring of CBC, liver enzymes, and renal function is essential
  3. Inform your doctor of any signs of infection like fever or sore throat
  4. Patients should report unusual bruising or bleeding
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