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Dabaz 500mg - Dacarbazine For Injuction

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Dabaz 500mg - Dacarbazine For Injuction

Dabaz 500mg (Dacarbazine for Injection) is a chemotherapy drug used to treat Hodgkin’s lymphoma, metastatic melanoma, and certain sarcomas. It works by disrupting cancer cell DNA, preventing their growth and replication.

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Description Product Details
General Information:
Generic Name: Dacarbazine
Brand Name: Dabaz
Packing: Vial for intravenous (IV) injection
Strength: 500mg
Manufacturer: [Specify Manufacturer]
Form: Injectable Powder for Reconstitution
Category: Alkylating Agent (Chemotherapy Drug)
Product Introduction:
Dabaz 500mg contains Dacarbazine, a cytotoxic alkylating agent used in chemotherapy for various cancers, particularly metastatic melanoma and Hodgkin’s lymphoma. It is administered intravenously (IV) under strict medical supervision.
Uses of Dabaz 500mg
Dabaz 500mg is prescribed for the treatment of:
  1. Metastatic Malignant Melanoma – Advanced stage of skin cancer.
  2. Hodgkin’s Lymphoma – Commonly part of the ABVD chemotherapy regimen.
  3. Soft Tissue Sarcomas – Treats cancers affecting muscles, fat, and connective tissues.
  4. Neuroblastoma – Cancer originating in nerve tissues.
  5. Pancreatic Neuroendocrine Tumors (Off-label Use) – Used in some rare cases.
✅ Dabaz 500mg is effective in slowing the spread of cancer cells by preventing their replication.
How Dabaz Works (Mechanism of Action):
  1. Alkylating Agent: Directly damages the DNA structure, preventing cancer cell multiplication.
  2. Prodrug Activation: Converts into an active form in the liver, which then targets cancer cells.
  3. Cell Cycle-Specific: Primarily affects the S-phase (DNA synthesis phase), leading to cancer cell death.
🔬 Dabaz 500mg interferes with DNA replication, ultimately leading to programmed cell death (apoptosis).
Dosage of Dabaz 500mg
Typical Recommended Dose:
Dosage depends on the type of cancer and individual patient condition:
  1. Metastatic Melanoma: 4.5 mg/kg IV per day for 10 days, repeated every 4 weeks.
  2. Hodgkin’s Lymphoma: 150 mg/m² IV per day for 5 days, repeated every 4 weeks (part of ABVD regimen).
  3. Soft Tissue Sarcomas: 250 mg/m² IV daily for 5 days, repeated every 3 weeks.
⚠️ Dosage adjustments are required for patients with liver or kidney impairment.
Method of Administration (How to Take It)
  1. Administered as a slow IV infusion in a hospital or clinic.
  2. Must be diluted and prepared under sterile conditions before use.
  3. Pre-treatment with anti-nausea medications is recommended.
  4. Adequate hydration is essential to prevent kidney damage.
💡 Frequent blood tests are required to monitor white blood cell counts and liver function.
Side Effects of Dabaz 500mg
Common Side Effects:
  1. Nausea & Vomiting (Severe in Some Cases)
  2. Loss of Appetite & Weight Loss
  3. Fatigue & Weakness
  4. Low Blood Cell Counts (Leukopenia, Anemia, Thrombocytopenia)
  5. Flu-like Symptoms (Fever, Chills, Muscle Pain)
Serious Side Effects (Seek Medical Help Immediately):
  1. Severe Bone Marrow Suppression: Increases risk of infections and bleeding.
  2. Liver Toxicity (Hepatotoxicity): Can cause jaundice and liver damage.
  3. Severe Allergic Reactions: Symptoms include rash, difficulty breathing, and swelling.
  4. Kidney Damage: May cause increased creatinine levels and reduced urine output.
🚨 Seek immediate medical help if you experience jaundice, unexplained bleeding, or persistent flu-like symptoms.
Precautions Before Taking Dabaz
  1. Monitor Liver and Kidney Function: Dose adjustments may be required.
  2. Ensure Adequate Hydration: Helps in flushing out toxic metabolites.
  3. Regular Blood Tests Required: To monitor blood cell counts and liver function.
  4. Avoid Pregnancy & Breastfeeding: High risk of birth defects.
  5. Use Effective Contraception: Both men and women should use protection during and after treatment.
  6. Avoid Alcohol & Other Hepatotoxic Drugs: To reduce liver toxicity risk.
  7. Do Not Take Live Vaccines (MMR, Polio, Yellow Fever): Risk of life-threatening infections.
⚠️ Report any unexplained bruising, fever, or yellowing of the skin immediately.
Drug Interactions (Medications That May Interact)
Dabaz 500mg may interact with:
  1. Phenytoin (Seizure Medication): May reduce chemotherapy effectiveness.
  2. Warfarin (Blood Thinner): Increases risk of excessive bleeding.
  3. Live Vaccines (Polio, MMR, Yellow Fever): Can cause severe infections.
  4. NSAIDs (Ibuprofen, Aspirin): May worsen kidney toxicity.
  5. Other Chemotherapy Agents (Cisplatin, Vinblastine): May increase toxicity.
⚠️ Inform your doctor about all medications and supplements you are taking before starting Dabaz.
Allergy Warnings
  1. Do not take if allergic to Dacarbazine or other alkylating agents.
  2. Watch for symptoms like severe rash, swelling, or breathing difficulty.
🚨 Seek emergency medical attention if an allergic reaction occurs.
Storage Instructions
  1. Store below 25°C (Room Temperature).
  2. Keep away from direct sunlight and moisture.
  3. Once reconstituted, use immediately or store as per medical guidelines.
  4. Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
  1. Severe Bone Marrow Suppression (Risk of life-threatening infections).
  2. Liver Failure (Jaundice, High Liver Enzymes).
  3. Extreme Fatigue & Weakness.
  4. Flu-like Symptoms (High Fever, Chills, Muscle Pain).
What to Do in Case of Overdose?
  1. Seek immediate medical help.
  2. Supportive care, IV fluids, and blood transfusions may be required.
  3. Liver function tests and dialysis may be needed in severe cases.
Missed Dose Instructions
  1. If a dose is missed, consult your doctor immediately.
  2. Do not take a double dose.
  3. Continue with the regular chemotherapy schedule.

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