Product Introduction:
Aprecap 125/80 mg is a combination therapy designed to prevent acute and delayed nausea and vomiting caused by chemotherapy or surgery. It is usually prescribed alongside corticosteroids (Dexamethasone) and serotonin (5-HT3) antagonists (Ondansetron/Granisetron) for maximum effectiveness.
Uses of Aprecap 125/80 mg
Aprecap is prescribed for:
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Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) – Especially with cisplatin-based regimens.
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Postoperative nausea and vomiting (PONV) prevention – Reduces vomiting after surgery.
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Prevention of nausea in radiation therapy – Helps in whole-body radiation-induced nausea.
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Enhancing the effectiveness of standard anti-emetic therapy – Used with Ondansetron or Granisetron.
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Improving patient compliance in cancer therapy – Helps patients complete chemotherapy cycles without vomiting-related discomfort.
How Aprecap 125/80 mg Works (Mechanism of Action):
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Aprepitant blocks the neurokinin-1 (NK1) receptors in the brain, which prevents substance P from binding.
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Substance P is responsible for triggering vomiting, especially in chemotherapy patients.
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By blocking this pathway, Aprecap prevents both immediate (acute) and delayed vomiting caused by chemotherapy or surgery.
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Works best when combined with serotonin (5-HT3) antagonists like Ondansetron and corticosteroids like Dexamethasone.
Dosage of Aprecap 125/80 mg
Recommended Dosage for Chemotherapy-Induced Nausea and Vomiting (CINV):
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Day 1 (Before chemotherapy): 125 mg taken 1 hour before chemotherapy.
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Day 2 & Day 3: 80 mg once daily, taken in the morning.
Dosage for Postoperative Nausea and Vomiting (PONV):
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40 mg as a single dose taken before anesthesia.
📌 Always follow your doctor's prescription for the best results.
Method of Administration (How to Take It)
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Take the capsule with or without food.
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Swallow the capsule whole with water—do not crush, chew, or break it.
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Take at the same time each day for scheduled doses.
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Start the regimen before chemotherapy for best protection.
Side Effects of Aprecap 125/80 mg
Common Side Effects:
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Fatigue and dizziness
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Hiccups
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Constipation or diarrhea
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Loss of appetite
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Headache
Severe Side Effects (Seek Medical Help Immediately):
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Severe allergic reactions – Swelling, difficulty breathing, severe rash.
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Liver issues – Yellowing of skin/eyes, dark urine, right upper stomach pain.
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Irregular heartbeat or fainting
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Severe skin reactions – Peeling skin, redness, blisters.
⚠️ Regular monitoring of liver function is recommended.
Precautions Before Taking Aprecap 125/80 mg
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Liver Disease: May require dose adjustment—consult your doctor.
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Pregnancy & Breastfeeding: Not recommended—may harm the baby.
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Kidney Issues: Use cautiously if you have kidney impairment.
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Driving & Machinery: May cause dizziness—avoid driving if affected.
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Diabetes: May affect blood sugar levels—monitor accordingly.
Drug Interactions (Medications That May Interact)
Aprecap can interact with:
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Warfarin (Blood Thinners) – Reduces Warfarin effectiveness—monitor INR levels.
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Oral Contraceptives (Birth Control Pills) – Reduces effectiveness—use alternative contraception.
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CYP3A4 Substrates (Rifampin, Ketoconazole, Clarithromycin) – Can alter Aprepitant metabolism.
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Dexamethasone & Methylprednisolone – Dosage adjustments may be needed.
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Serotonin Antagonists (Ondansetron, Granisetron, Palonosetron) – Safe but needs proper scheduling.
⚠️ Always inform your doctor about any medications you are taking.
Allergy Warnings
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Do not take Aprecap if allergic to Aprepitant or its ingredients.
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Signs of an allergic reaction:
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Swelling of face, lips, or throat
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Difficulty breathing
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Severe rash or itching
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Dizziness or fainting
🚨 Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
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Store at room temperature (15°C - 30°C / 59°F - 86°F).
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Keep in original packaging to protect from moisture and light.
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Keep away from children and pets.
Overdose Information
Symptoms of overdose:
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Severe drowsiness or dizziness
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Severe nausea or vomiting
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Confusion or trouble breathing
What to do in case of overdose?
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Seek immediate medical attention.
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Hospitalization may be required for supportive care.
Missed Dose Instructions
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If missed before chemotherapy: Take it as soon as possible before treatment.
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If missed on Day 2 or 3: Take it as soon as remembered, but do not double the dose.
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If the chemotherapy cycle is over: No need to take the missed dose.
