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Bevacirel 100mg - Bevacizumab Injections

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Bevacirel 100mg - Bevacizumab Injections

Bevacirel 100mg Injection contains Bevacizumab, a monoclonal antibody used to treat various cancers, including colorectal, lung, kidney, ovarian, and brain cancers. It inhibits vascular endothelial growth factor (VEGF) to prevent tumor growth by cutting off its blood supply.

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Description Product Details
General Information:
Generic Name: Bevacizumab
Brand Name: Bevacirel
Packing: Vial for Injection
Strength: 100mg/4mL
Company: Reliance Life Science Pvt. Ltd.
Form: Solution for Intravenous Infusion
Category: Monoclonal Antibody, Anti-Cancer, VEGF Inhibitor
Product Introduction:
Bevacirel 100mg Injection is an anti-angiogenic monoclonal antibody that targets VEGF, blocking new blood vessel formation in tumors. This helps slow down the growth of cancer cells and is commonly used in combination with chemotherapy. It is administered intravenously (IV) under medical supervision.
Uses of Bevacirel 100mg
Bevacirel 100mg is used in the treatment of:
  1. Metastatic Colorectal Cancer (mCRC) – In combination with chemotherapy.
  2. Non-Small Cell Lung Cancer (NSCLC) – Advanced/metastatic cases.
  3. Ovarian and Cervical Cancer – Combined with chemotherapy.
  4. Renal Cell Carcinoma (Kidney Cancer) – For advanced stages.
  5. Glioblastoma (Brain Cancer) – Used when other treatments fail.
  6. Other Solid Tumors (Off-label Use) – As per doctor’s recommendation.
How Bevacirel 100mg Works (Mechanism of Action):
  1. Bevacizumab binds to VEGF, preventing it from interacting with its receptors on endothelial cells.
  2. VEGF is crucial for angiogenesis (new blood vessel formation), which supports tumor growth.
  3. By blocking VEGF, Bevacirel starves the tumor by cutting off its oxygen and nutrient supply.
Dosage of Bevacirel 100mg
Typical Recommended Dose: 
  1. Metastatic Colorectal Cancer (mCRC):
    1. 5 mg/kg IV every 2 weeks or 7.5 mg/kg IV every 3 weeks with chemotherapy.
  2. Non-Small Cell Lung Cancer (NSCLC):
    1. 15 mg/kg IV every 3 weeks with chemotherapy.
  3. Renal Cell Carcinoma (Kidney Cancer):
    1. 10 mg/kg IV every 2 weeks.
  4. Glioblastoma (Brain Cancer):
    1. 10 mg/kg IV every 2 weeks as monotherapy.
📌 Dose may be adjusted based on patient weight and condition.
Method of Administration (How to Take It)
  1. Administered via intravenous (IV) infusion in a hospital setting.
  2. First infusion: Given over 90 minutes; later doses may be given in 30-60 minutes if tolerated.
  3. Not for self-administration – should be given under medical supervision.
  4. Premedication (anti-nausea drugs) may be provided to reduce side effects.
Side Effects of Bevacirel 100mg
Common Side Effects:
  1. High blood pressure (hypertension)
  2. Fatigue and weakness
  3. Nosebleeds
  4. Nausea and vomiting
  5. Diarrhea or constipation
  6. Loss of appetite
Severe Side Effects (Seek Medical Help Immediately):
  1. Severe bleeding – Vomiting blood, black stools.
  2. Gastrointestinal perforation – Severe stomach pain.
  3. Delayed wound healing – Avoid before/after surgery.
  4. Blood clot formation – Stroke or deep vein thrombosis.
  5. Kidney problems – Protein in urine, swelling in feet.
⚠️ Regular blood pressure and kidney function monitoring is required.
Precautions Before Taking Bevacirel 100mg
  • Pregnant & Breastfeeding Women: Avoid use, as it may harm the baby.
  • Surgery Patients: Stop Bevacirel at least 28 days before & after surgery to prevent wound healing complications.
  • Heart Disease or Stroke Patients: Increased risk of blood clots.
  • High Blood Pressure Patients: Regular monitoring required.
Drug Interactions (Medications That May Interact)
Bevacirel 100mg may interact with:
  1. Blood Thinners (Warfarin, Aspirin, Heparin): Increases bleeding risk.
  2. NSAIDs (Ibuprofen, Naproxen): May worsen kidney damage.
  3. Other Cancer Therapies: Adjustments may be required.
  4. Immunosuppressants (Corticosteroids, Cyclosporine): May alter immune response.
⚠️ Inform your doctor about all medicines and supplements you take.
Allergy Warnings
  1. Do not use if allergic to Bevacizumab or its ingredients.
  2. Signs of an allergic reaction:
    1. Swelling of face, lips, or throat
    2. Rash, itching, or severe dizziness
    3. Difficulty breathing
🚨 Seek emergency help if an allergic reaction occurs.
Storage Instructions
  1. Store in a refrigerator at 2°C - 8°C.
  2. Do not freeze or shake the vial.
  3. Keep in original packaging, away from light.
  4. Use within the prescribed period after dilution.
Overdose Information
Symptoms of overdose:
  1. Severe high blood pressure
  2. Excessive bleeding
  3. Severe kidney or liver dysfunction
What to do in case of overdose?
  1. Seek immediate medical attention.
  2. Hospitalization and symptomatic treatment required.
Missed Dose Instructions
  1. Contact your doctor immediately if a dose is missed.
  2. Do not self-administer a missed dose.
  3. Do not double up on doses.

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