Gemtaz 200mg is an anti-cancer chemotherapy injection used to treat a variety of cancers, including lung, pancreatic, ovarian, and breast cancers. It works by slowing or stopping the growth of cancer cells.
Gemtaz 200mg is a lyophilized powder for solution, containing Gemcitabine, a chemotherapy drug classified as an antimetabolite. It is administered intravenously under medical supervision and used in both monotherapy and combination therapy protocols for various cancers.
Uses:
Gemtaz 200mg is commonly used in the treatment of:
Non-Small Cell Lung Cancer (NSCLC)
Pancreatic Cancer
Breast Cancer
Ovarian Cancer
Bladder Cancer
Cholangiocarcinoma (Bile Duct Cancer)
Storage Instructions:
Store below 25°C in a dry place
Protect from light and moisture
After reconstitution, store refrigerated (2°C – 8°C) and use within 24 hours
Do not freeze the reconstituted solution
How it Works (Mechanism of Action):
Gemcitabine is a nucleoside analog that mimics natural DNA building blocks. Once inside the cell, it interferes with DNA synthesis by integrating into the DNA strands during replication, thereby halting cell division and inducing apoptosis in rapidly dividing cancer cells.
Side Effects:
Common Side Effects:
Fatigue
Nausea and vomiting
Mild fever or flu-like symptoms
Anemia and low white blood cell counts
Skin rash or irritation at injection site
Severe Side Effects:
Pulmonary toxicity
Liver enzyme elevation
Kidney dysfunction
Myelosuppression
Rare: Hemolytic uremic syndrome
Dosage (Typical Recommended Dose):
The typical adult dose is 1000mg/m² IV on days 1, 8, and 15 of a 28-day cycle
Gemtaz 200mg may be used in fractional doses based on body surface area or combination regimens
Dosing adjustments are made based on blood counts and organ function
Method of Administration:
Reconstitute the vial with sterile water for injection
Administer as an intravenous infusion over 30 minutes
Only to be administered under the supervision of an oncologist or trained healthcare provider
Precautions:
Contraindicated in pregnancy and breastfeeding
Monitor blood counts before each dose
Use with caution in patients with liver or kidney impairment
Avoid exposure to infections during therapy
Use effective contraception during treatment
Drug Interactions:
Concurrent use with platinum-based drugs (e.g., cisplatin) may enhance side effects
May potentiate bleeding risk when used with anticoagulants like warfarin
Immunosuppressive effects may increase infection risk with live vaccines
Allergies:
Do not use in patients with known hypersensitivity to Gemcitabine
Watch for signs of allergic reaction: hives, difficulty breathing, swelling of face/lips/throat
Overdose Information:
Overdose can lead to severe suppression of bone marrow, liver damage, and organ failure
Emergency supportive treatment and monitoring are critical
No specific antidote exists
Missed Dose Instructions:
If a dose is missed, consult the treating oncologist immediately
Treatment schedules may be adjusted by the physician
Do not self-administer or alter dosing without medical supervision
Additional Notes:
Regular monitoring through blood tests and imaging is necessary during treatment
Avoid alcohol and maintain proper hydration during therapy
Report signs of infection, unusual bruising, or bleeding immediately
Product Intro:
Gemtaz 200mg is a lyophilized powder for solution, containing Gemcitabine, a chemotherapy drug classified as an antimetabolite. It is administered intravenously under medical supervision and used in both monotherapy and combination therapy protocols for various cancers.
Uses:
Gemtaz 200mg is commonly used in the treatment of:
Non-Small Cell Lung Cancer (NSCLC)
Pancreatic Cancer
Breast Cancer
Ovarian Cancer
Bladder Cancer
Cholangiocarcinoma (Bile Duct Cancer)
Storage Instructions:
Store below 25°C in a dry place
Protect from light and moisture
After reconstitution, store refrigerated (2°C – 8°C) and use within 24 hours
Do not freeze the reconstituted solution
How it Works (Mechanism of Action):
Gemcitabine is a nucleoside analog that mimics natural DNA building blocks. Once inside the cell, it interferes with DNA synthesis by integrating into the DNA strands during replication, thereby halting cell division and inducing apoptosis in rapidly dividing cancer cells.
Side Effects:
Common Side Effects:
Fatigue
Nausea and vomiting
Mild fever or flu-like symptoms
Anemia and low white blood cell counts
Skin rash or irritation at injection site
Severe Side Effects:
Pulmonary toxicity
Liver enzyme elevation
Kidney dysfunction
Myelosuppression
Rare: Hemolytic uremic syndrome
Dosage (Typical Recommended Dose):
The typical adult dose is 1000mg/m² IV on days 1, 8, and 15 of a 28-day cycle
Gemtaz 200mg may be used in fractional doses based on body surface area or combination regimens
Dosing adjustments are made based on blood counts and organ function
Method of Administration:
Reconstitute the vial with sterile water for injection
Administer as an intravenous infusion over 30 minutes
Only to be administered under the supervision of an oncologist or trained healthcare provider
Precautions:
Contraindicated in pregnancy and breastfeeding
Monitor blood counts before each dose
Use with caution in patients with liver or kidney impairment
Avoid exposure to infections during therapy
Use effective contraception during treatment
Drug Interactions:
Concurrent use with platinum-based drugs (e.g., cisplatin) may enhance side effects
May potentiate bleeding risk when used with anticoagulants like warfarin
Immunosuppressive effects may increase infection risk with live vaccines
Allergies:
Do not use in patients with known hypersensitivity to Gemcitabine
Watch for signs of allergic reaction: hives, difficulty breathing, swelling of face/lips/throat
Overdose Information:
Overdose can lead to severe suppression of bone marrow, liver damage, and organ failure
Emergency supportive treatment and monitoring are critical
No specific antidote exists
Missed Dose Instructions:
If a dose is missed, consult the treating oncologist immediately
Treatment schedules may be adjusted by the physician
Do not self-administer or alter dosing without medical supervision
Additional Notes:
Regular monitoring through blood tests and imaging is necessary during treatment
Avoid alcohol and maintain proper hydration during therapy
Report signs of infection, unusual bruising, or bleeding immediately
