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Ciclib 100mg - Palbociclib Capsules

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Ciclib 100mg - Palbociclib Capsules

Ciclib 100mg contains Palbociclib, a targeted therapy used in combination with hormone therapies to treat advanced or metastatic HR-positive, HER2-negative breast cancer. It helps slow the progression of cancer by inhibiting cancer cell division.

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Description Product Details
General Information:
Generic Name: Palbociclib
Brand Name: Ciclib
Packing: Bottle (typically 21 or 30 capsules per pack)
Strength: 100 mg
Manufacturer: [To be specified – generally produced by oncology-focused pharmaceutical firms]
Form: Capsules
Category: Anticancer, Targeted Therapy, CDK4/6 Inhibitor
Product Intro:
Ciclib 100mg is a cyclin-dependent kinase (CDK) 4/6 inhibitor, used in treating hormone receptor (HR)-positive, HER2-negative breast cancer. It is often prescribed alongside endocrine therapy (like letrozole or fulvestrant) for postmenopausal women or men with advanced-stage breast cancer. Manufactured to meet oncology standards, Ciclib offers effective oral therapy in capsule form.
Uses:
  1. Treatment of HR-positive, HER2-negative advanced breast cancer
  2. Used in combination with aromatase inhibitors (e.g., letrozole)
  3. Combined with fulvestrant for disease progression following endocrine therapy
  4. First-line or second-line therapy in metastatic breast cancer
  5. Treatment in both postmenopausal women and men with breast cancer
  6. Investigated for other solid tumors in clinical settings
Storage Instructions:
  1. Store below 30°C (86°F) in a dry place
  2. Keep in original container and away from light and moisture
  3. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Palbociclib selectively inhibits cyclin-dependent kinases 4 and 6 (CDK4/6).
  1. These enzymes regulate cell cycle progression from G1 to S phase.
  2. In hormone-positive cancers, CDK4/6 activity is often upregulated, leading to uncontrolled growth.
  3. By inhibiting CDK4/6, Ciclib slows cancer cell division, promoting tumor growth arrest and improved outcomes when used with hormonal therapy.
Side Effects:
Common Side Effects:
  1. Neutropenia (low white blood cells)
  2. Fatigue
  3. Nausea
  4. Diarrhea
  5. Hair thinning or loss
  6. Mouth sores
  7. Decreased appetite
Serious Side Effects:
  1. Infections due to low white cell count
  2. Liver function abnormalities
  3. Pulmonary embolism (rare)
  4. Anemia and thrombocytopenia
  5. Lung inflammation (rare)
Dosage (Typical Recommended Dose):
  1. Usual dose: 125 mg once daily for 21 days, followed by 7 days off (28-day cycle)
  2. In case of side effects, it may be reduced to 100 mg or 75 mg per day
  3. Ciclib 100mg is a common adjusted dose after initial full-dose treatment
  4. Must be taken under close medical supervision
Method of Administration:
  1. Take the capsule orally once a day
  2. Swallow whole with water – do not chew, crush, or open
  3. Take with food to improve absorption
  4. Maintain consistent timing daily
Precautions:
  1. Not recommended during pregnancy or breastfeeding
  2. Regular monitoring of complete blood counts (CBC) is necessary
  3. Use with caution in patients with liver or kidney disorders
  4. Avoid grapefruit or grapefruit juice – can alter drug metabolism
  5. Avoid live vaccines while on treatment
  6. May cause dizziness or fatigue – avoid driving if affected
Drug Interactions:
  1. Avoid strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin)
  2. Avoid CYP3A inducers (e.g., rifampin, carbamazepine)
  3. Careful with drugs that prolong QT interval
  4. Inform your doctor about all prescription, OTC, and herbal supplements
Allergies:
  1. Do not take if allergic to Palbociclib or any component of the capsule
  2. Signs of allergy: rash, itching, swelling, dizziness, trouble breathing
Overdose Information:
  1. Symptoms: Severe fatigue, infections, or blood count suppression
  2. Seek emergency medical help in case of overdose
  3. No specific antidote; treatment is supportive and symptomatic
Missed Dose Instructions:
  1. If a dose is missed by less than 12 hours, take it as soon as remembered
  2. If more than 12 hours have passed, skip the missed dose
  3. Do not double the dose the next day
Additional Notes:
  1. Women of childbearing age should use effective contraception
  2. Male patients should use contraception during treatment and for at least 3 months after
  3. Routine blood tests are critical to avoid complications
  4. It’s important to maintain open communication with your doctor regarding side effects
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