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Cresp 60mg - Darbepoetin Alfa Injection

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Cresp 60mg - Darbepoetin Alfa Injection

Cresp 60mcg is an erythropoiesis-stimulating agent (ESA) used to treat anemia in patients with chronic kidney disease (CKD) or chemotherapy-induced anemia. It works by stimulating the bone marrow to produce red blood cells, reducing the need for blood transfusions.

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Description Product Details
General Information:
Generic Name: Darbepoetin Alfa
Brand Name: Cresp
Packing: Pre-filled syringe or vial
Strength: 60mcg per injection
Manufacturer: Dr. Reddy’s Laboratories
Form: Injectable Solution
Category: Erythropoiesis-Stimulating Agent (ESA)
Product Introduction:
Cresp 60mcg is a long-acting recombinant erythropoietin used to treat anemia in patients with CKD and those undergoing chemotherapy. It improves oxygen transport in the body, reducing fatigue, dizziness, and weakness associated with low red blood cell counts.
Uses of Cresp 60mcg
Cresp 60mcg is used to treat anemia caused by the following conditions:
  1. Chronic Kidney Disease (CKD): Helps maintain hemoglobin levels and reduces the need for blood transfusions.
  2. Chemotherapy-Induced Anemia: Used in cancer patients undergoing chemotherapy.
  3. HIV-Associated Anemia: Helps boost red blood cell production in HIV-positive patients.
  4. Bone Marrow Disorders: Used in patients with bone marrow suppression leading to low RBC production.
  5. Pre-Surgical Use: Helps reduce the need for blood transfusions before surgery.
How Cresp 60mcg Works (Mechanism of Action)
Darbepoetin Alfa is a synthetic form of erythropoietin, a natural hormone that stimulates the bone marrow to produce red blood cells.
  1. It binds to erythropoietin receptors in the bone marrow, increasing red blood cell production.
  2. It has a longer half-life than natural erythropoietin, requiring less frequent dosing.
  3. Improves oxygen supply to tissues and reduces symptoms of anemia.
Dosage of Cresp 60mcg
Typical Recommended Dose:
  1. Chronic Kidney Disease (CKD):
    1. Initial Dose: 0.45 mcg/kg once weekly or 0.75 mcg/kg once every two weeks.
    2. Maintenance Dose: Adjust based on hemoglobin levels.
  2. Chemotherapy-Induced Anemia:
    1. Initial Dose: 2.25 mcg/kg once weekly or 500 mcg every three weeks.
    2. Maintenance Dose: Adjust as needed.
💡 Dosage should be individualized based on hemoglobin response.
Method of Administration (How to Take It)
  1. Injection Route:
    1. Subcutaneous (under the skin): Preferred for long-term use.
    2. Intravenous (IV): Often used in dialysis patients.
  2. Injection Sites: Abdomen, thigh, or upper arm.
  3. Self-Administration: Patients can be trained to inject at home.
⚠️ Follow proper injection techniques to avoid complications.
Side Effects of Cresp 60mcg
Common Side Effects:
  1. Fatigue
  2. Headache
  3. Nausea and vomiting
  4. Muscle or joint pain
  5. Mild injection site reactions (redness, swelling, pain)
Serious Side Effects (Seek Immediate Medical Help):
  1. High Blood Pressure (Hypertension)
  2. Blood Clots (Thrombosis)
  3. Heart Attack or Stroke
  4. Severe Allergic Reactions (rash, swelling, difficulty breathing)
  5. Seizures (rare but possible)
🚨 Regular monitoring is necessary to prevent complications.
Precautions Before Taking Cresp 60mcg
  1. Hypertension: Monitor blood pressure regularly.
  2. Heart Disease: Use with caution in patients with cardiovascular conditions.
  3. Iron Levels: Ensure adequate iron levels for best results.
  4. Pregnancy & Breastfeeding: Consult a doctor before use.
  5. Allergy Warning: Avoid if allergic to Darbepoetin.
Drug Interactions (Medications That May Interact)
  1. Antihypertensive Drugs: May cause blood pressure fluctuations.
  2. Iron Supplements: Often required for best results.
  3. Blood Thinners (Anticoagulants): Increased risk of blood clots.
  4. Other ESAs: Should not be combined without doctor’s approval.
Allergy Warnings
  1. Do not take if allergic to Darbepoetin or its ingredients.
  2. Symptoms of severe allergy: Rash, swelling, difficulty breathing.
  3. Seek medical help if an allergic reaction occurs.
Storage Instructions
  1. Store in a refrigerator (2°C to 8°C).
  2. Do not freeze.
  3. Protect from light and keep in original packaging.
  4. Keep out of reach of children.
Overdose Information
Symptoms of Overdose:
  1. Severe hypertension
  2. Headaches and dizziness
  3. Shortness of breath
What to Do in Case of Overdose?
  1. Seek emergency medical attention.
  2. Monitor blood pressure and cardiovascular function.
Missed Dose Instructions
  1. If you miss a dose: Take it as soon as possible unless it’s near the next dose.
  2. Do not double the dose to make up for the missed one.

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