Product Introduction:
Abiracure 250 mg (Abiraterone Acetate) is a targeted therapy used in the treatment of advanced or metastatic prostate cancer. It helps in reducing androgen levels, which are essential for the growth of prostate cancer cells. This medicine is usually prescribed in combination with prednisone to minimize side effects like hypertension and fluid retention.
Uses of Abiracure 250 mg
Abiracure is mainly used for treating prostate cancer, particularly in advanced stages. It may also have additional off-label uses, but its primary indications include:
-
Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Used when prostate cancer has spread and does not respond to standard hormone therapy.
-
Metastatic High-Risk Castration-Sensitive Prostate Cancer (mCSPC) – In combination with prednisone to improve survival rates.
-
Hormone Therapy-Resistant Prostate Cancer – When the cancer continues to progress despite other treatments.
-
Reduction of Tumor Growth – By lowering androgen production, it slows down tumor development.
-
Prevention of Disease Progression – Helps in delaying the spread of prostate cancer.
-
Post-Surgical Treatment – Sometimes used in patients who have undergone prostate removal surgery to prevent recurrence.
How Abiracure 250 mg Works (Mechanism of Action):
Abiracure (Abiraterone Acetate) is a CYP17 inhibitor that blocks the production of androgens (testosterone and other male hormones), which fuel the growth of prostate cancer cells.
-
It inhibits CYP17 enzyme activity in the adrenal glands, testes, and prostate tumor cells.
-
This prevents the conversion of pregnenolone and progesterone into testosterone, leading to reduced androgen levels.
-
Lowering androgens slows tumor progression and cancer cell proliferation.
Since Abiraterone affects the hormone system, it is usually combined with prednisone to reduce side effects like high blood pressure and fluid retention.
Dosage of Abiracure 250 mg
Recommended Dosage:
-
Typical dose: 1000 mg (four 250 mg tablets) once daily
-
Taken with prednisone: Usually 5 mg twice daily
-
Doctor may adjust the dose based on patient response and side effects.
For patients with liver issues:
-
Dose adjustments may be necessary based on liver function.
Method of Administration (How to Take It)
-
Take Abiracure on an empty stomach, at least 1 hour before or 2 hours after a meal.
-
Swallow the tablets whole with a glass of water.
-
Do not chew, crush, or break the tablets.
-
Take it at the same time every day for best results.
-
Prednisone is required to be taken alongside Abiracure to reduce side effects.
Side Effects of Abiracure 250 mg
Common Side Effects:
-
Fatigue & Weakness
-
High blood pressure (Hypertension)
-
Swelling in legs or feet (Fluid retention/Edema)
-
Low potassium levels (Hypokalemia)
-
Hot flashes
-
Increased liver enzymes
-
Joint pain (Arthralgia)
Severe Side Effects:
-
Heart problems (Arrhythmias, Heart failure)
-
Severe liver damage (Hepatotoxicity)
-
Adrenal insufficiency
-
Severe allergic reactions (Rash, swelling, difficulty breathing)
⚠️ Contact a doctor if you experience serious side effects like severe dizziness, chest pain, or yellowing of the skin (jaundice).
Precautions Before Taking Abiracure 250 mg
-
Not for use in women or children – Can cause severe harm if used by pregnant women.
-
Monitor blood pressure and liver function regularly.
-
Caution in heart disease patients – May increase the risk of heart complications.
-
Avoid grapefruit or grapefruit juice – It may increase side effects.
-
Use effective contraception – Can be harmful if a male patient’s partner is pregnant.
Drug Interactions (Medications That May Interact)
Abiracure 250 mg can interact with several medications:
Avoid using with:
-
Strong CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce effectiveness.
-
CYP2D6 substrates (e.g., Metoprolol, Codeine) – Can alter drug levels.
-
Blood thinners (Warfarin, Heparin) – May increase bleeding risk.
-
Corticosteroids (other than prednisone) – Can lead to hormonal imbalance.
-
Heart medications (Digoxin, Amiodarone) – Risk of cardiac issues.
Allergy Warnings
-
Do not use if allergic to Abiraterone Acetate or any ingredients in Abiracure.
-
Signs of allergy: Rash, swelling, severe itching, difficulty breathing.
-
Seek medical help immediately if an allergic reaction occurs.
Storage Instructions
-
Store at room temperature (15-30°C or 59-86°F).
-
Keep in a dry place, away from moisture and heat.
-
Keep out of reach of children.
-
Do not use expired medication.
Overdose Information
Symptoms of overdose:
-
Severe dizziness or fainting
-
Irregular heartbeat
-
Confusion or trouble breathing
What to do in case of overdose?
-
Seek emergency medical help immediately.
-
Contact a poison control center or go to the nearest hospital.
Missed Dose Instructions
-
If you miss a dose, take it as soon as you remember.
-
If it is almost time for the next dose, skip the missed dose—do not double the dose.
-
Never take extra tablets to make up for a missed dose.
Additional Notes:
-
Regular blood tests are required to monitor potassium levels, liver function, and blood pressure.
-
Do not stop taking the medication suddenly without consulting a doctor.
-
Follow a healthy lifestyle with a balanced diet and exercise for better results.
