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Gempower 200mg - Gemcitabine for Injection

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Gempower 200mg - Gemcitabine for Injection

Gempower 200mg is a chemotherapy medication used to treat a variety of cancers such as lung, pancreatic, breast, ovarian, and bladder cancer. It works by interfering with the growth of cancer cells, stopping their multiplication.

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Description Product Details
General Information:
Generic Name: Gemcitabine Hydrochloride
Brand Name: Gempower
Packing: Single-use vial
Strength: 200mg
Manufacturer: Khandelwal Laboratories Pvt.Ltd
Form: Lyophilized Powder for Injection
Category: Antineoplastic / Chemotherapy / Antimetabolite
Product Intro:
Gempower 200mg contains Gemcitabine, an antineoplastic agent used as part of chemotherapy regimens. It is administered intravenously and is vital in treating both locally advanced and metastatic cancers. This formulation is ideal for flexible, patient-specific dosing.
Uses:
Gempower 200mg is indicated for the treatment of:
  1. Non-Small Cell Lung Cancer (NSCLC)
  2. Pancreatic Cancer
  3. Breast Cancer
  4. Ovarian Cancer
  5. Bladder Cancer
  6. Bile Duct Cancer (Cholangiocarcinoma)
Storage Instructions:
  1. Store below 25°C in a cool, dry place
  2. Protect from direct sunlight
  3. After reconstitution, store the solution in a refrigerator (2°C–8°C) and use within 24 hours
  4. Do not freeze the reconstituted solution
How it Works (Mechanism of Action):
Gemcitabine is a pyrimidine nucleoside analog that gets incorporated into DNA, inhibiting DNA synthesis. It also inhibits ribonucleotide reductase, reducing the pool of deoxynucleotides needed for DNA replication, ultimately leading to cancer cell death.
Side Effects:
Common Side Effects:
  1. Fatigue
  2. Nausea
  3. Vomiting
  4. Low blood cell counts (anemia, neutropenia)
  5. Fever
  6. Skin rash
Severe Side Effects:
  1. Pulmonary toxicity (shortness of breath, cough)
  2. Liver enzyme elevation
  3. Renal impairment
  4. Severe bone marrow suppression
  5. Hemolytic-uremic syndrome (rare)
Dosage (Typical Recommended Dose):
  1. Dosage is based on body surface area and the specific cancer type
  2. Typical dose: 1000 mg/m² IV on days 1, 8, and 15 of a 28-day cycle
  3. Gempower 200mg is often used in combination with other chemotherapy agents and in fractional doses to meet specific regimens
Method of Administration:
  1. Administered via intravenous infusion over 30 minutes
  2. Reconstitute with sterile water for injection
  3. Only to be administered by qualified healthcare professionals in a clinical setting
Precautions:
  1. Not recommended during pregnancy and lactation
  2. Use effective contraception during and after treatment
  3. Monitor liver, kidney functions, and blood cell counts regularly
  4. Avoid close contact with people who are ill or recently vaccinated with live vaccines
  5. Caution in patients with pre-existing organ dysfunction
Drug Interactions:
  1. Increased toxicity when used with cisplatin or other cytotoxic drugs
  2. Use with caution with anticoagulants like warfarin – monitor INR
  3. Avoid live vaccines during treatment
Allergies:
  1. Do not use in patients with known hypersensitivity to Gemcitabine
  2. Watch for signs of an allergic reaction such as rash, itching, facial swelling, or difficulty breathing
Overdose Information:
  1. Overdose can lead to severe bone marrow suppression, organ damage, or death
  2. Immediate medical attention and supportive care are required
  3. No specific antidote; treatment is symptomatic
Missed Dose Instructions:
  1. If a dose is missed, contact your healthcare provider immediately
  2. Do not double the dose without medical advice
  3. The physician may reschedule the treatment depending on the condition
Additional Notes:
  1. Ensure hydration before and after infusion to support kidney function
  2. Patients should avoid activities that may increase the risk of bleeding or infection
  3. Routine blood tests are essential to monitor progress and safety
  4. Dispose of unused or expired vials according to medical waste guidelines
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