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Rituxirel 500mg - Rituximab Injection

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Rituxirel 500mg - Rituximab Injection

Rituxirel 500mg is an anti-CD20 monoclonal antibody injection containing Rituximab, used primarily for treating certain types of cancers and autoimmune diseases. It works by targeting B lymphocytes, helping to manage both malignant and inflammatory conditions.

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Description Product Details
General Information:
Generic Name: Rituximab
Brand Name: Rituxirel
Packing: Vial
Strength: 500 mg/50ml
Manufacturer: Reliance Life Sciences
Form: Concentrate for Intravenous Infusion
Category: Anti-cancer, Immunotherapy, Biologic, Immunosuppressant
Product Intro:
Rituxirel 500mg is a prescription biological medicine classified as a monoclonal antibody therapy. It is used intravenously in hospital settings for the treatment of B-cell cancers such as non-Hodgkin’s lymphoma and chronic lymphocytic leukemia, and autoimmune diseases like rheumatoid arthritis.
Uses:
  1. Non-Hodgkin’s Lymphoma (NHL)
  2. Chronic Lymphocytic Leukemia (CLL)
  3. Rheumatoid Arthritis (RA) (in combination with methotrexate)
  4. Granulomatosis with Polyangiitis (GPA)
  5. Microscopic Polyangiitis (MPA)
  6. Investigational/off-label use in lupus nephritis, ITP, and multiple sclerosis
Storage Instructions:
  1. Store between 2°C to 8°C
  2. Do not freeze
  3. Protect from light
  4. Keep in original packaging until time of use
  5. Discard any leftover medication per institutional biohazard protocol
How it Works (Mechanism of Action):
Rituximab selectively targets CD20-positive B lymphocytes, marking them for destruction via:
  1. Complement-Dependent Cytotoxicity (CDC)
  2. Antibody-Dependent Cellular Cytotoxicity (ADCC)
  3. Apoptosis (programmed cell death)
    This action reduces the number of B cells that may be cancerous or involved in autoimmune activity.
Side Effects:
Common Side Effects:
  1. Fever, chills during or after infusion
  2. Fatigue
  3. Nausea
  4. Skin rashes
  5. Headache
  6. Respiratory infections
Serious Side Effects:
  1. Infusion-related reactions (hypotension, difficulty breathing)
  2. Hepatitis B reactivation
  3. Progressive Multifocal Leukoencephalopathy (PML) – rare but serious brain infection
  4. Severe neutropenia and thrombocytopenia
  5. Cardiac arrhythmias
Dosage (Typical Recommended Dose):
For NHL & CLL:
  1. 375 mg/m² body surface area, once weekly for 4–8 cycles
  2. In combination with chemotherapy (e.g., CHOP or FC regimens)
For Rheumatoid Arthritis:
  1. 1000 mg on Day 1 and Day 15
  2. Repeat courses every 6 months depending on clinical response
Rituxirel 500mg is commonly used as a full dose or part of a calculated BSA-based dose.
Method of Administration:
  1. IV infusion only; should never be given as IV push or bolus
  2. Diluted with 0.9% sodium chloride to desired volume
  3. Administered over several hours
  4. Premedication with antihistamines, paracetamol, and corticosteroids recommended to reduce infusion reactions
Precautions:
  1. Screen for Hepatitis B virus prior to initiation
  2. Avoid use in patients with active infections
  3. Do not use live vaccines during treatment
  4. Use cautiously in elderly and cardiac patients
  5. Avoid in pregnancy and breastfeeding unless absolutely necessary
Drug Interactions:
  1. Combination with chemotherapeutics (cyclophosphamide, fludarabine) may increase cytopenias
  2. Live vaccines should be avoided
  3. May interact with other biologic immunosuppressants
  4. Enhanced infection risk with immunomodulatory drugs
Allergies:
  1. Not suitable for patients with known hypersensitivity to Rituximab or murine proteins
  2. Allergic reactions may include swelling, rashes, breathing difficulty, and anaphylaxis
Overdose Information:
  1. Overdose may result in intensified side effects, particularly bone marrow suppression and infections
  2. No specific antidote; treatment is supportive and symptomatic
  3. Hospital monitoring recommended

Missed Dose Instructions:

  1. If a dose is missed, consult your doctor promptly
  2. Do not double the dose
  3. The treatment cycle may need rescheduling by a healthcare provider
Additional Notes:
  1. Close monitoring is essential during and after the first few infusions
  2. Patients should report fever, persistent infections, or unusual fatigue promptly
  3. Women of childbearing potential must use effective contraception during treatment and for at least 12 months after the last dose
  4. Healthcare professionals must adhere to cytotoxic handling guidelines
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