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Relipoietin 10000iu - Erythropoietin Injection

Relipoietin 10000 IU is a recombinant human erythropoietin alfa injection used to treat anemia in patients with chronic kidney disease, chemotherapy-induced anemia, or other conditions affecting red blood cell production. It works by stimulating red blood cell formation in the bone marrow.

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Description Product Details

General Information:

Generic Name: Erythropoietin Alfa

Brand Name: Relipoietin

Packing: Single-use prefilled syringe or vial

Strength: 10000 IU/1ml

Manufacturer: Reliance Life Sciences

Form: Injectable solution

Category: Hematopoietic Growth Factor / Anti-anemic Agent

Product Intro:

Relipoietin 10000 IU is a high-dose injectable formulation of Erythropoietin alfa, developed by Reliance Life Sciences. It is especially beneficial for patients requiring significant stimulation of red blood cell production, such as those undergoing dialysis, chemotherapy, or with advanced chronic diseases. This product helps reduce the need for blood transfusions and improves overall quality of life.

Uses:

Anemia in Chronic Kidney Disease (CKD) – both dialysis and non-dialysis patients
Chemotherapy-induced Anemia – in cancer patients
Anemia due to HIV therapy – especially in patients on zidovudine
Bone marrow disorders – such as myelodysplastic syndromes
Preoperative use – to reduce need for blood transfusions in elective surgeries
Anemia in critical illness or chronic inflammatory conditions

Storage Instructions:

Store at 2°C to 8°C (refrigerated)
Do not freeze
Keep away from direct sunlight
Let it reach room temperature before injecting
Do not shake the vial or syringe

How it Works (Mechanism of Action):

Erythropoietin alfa acts on the erythroid progenitor cells in the bone marrow by binding to specific receptors. This stimulation leads to the proliferation and differentiation of red blood cells, which helps in increasing hemoglobin and improving oxygen delivery throughout the body.

Side Effects:

Common Side Effects:

Injection site pain
Flu-like symptoms (fever, fatigue)
Headache
Nausea
Muscle aches

Severe Side Effects:

High blood pressure
Thromboembolic events (blood clots, stroke)
Seizures
Pure Red Cell Aplasia (PRCA) – rare but serious
Severe allergic reactions (e.g., anaphylaxis)

Dosage (Typical Recommended Dose):

Dialysis patients: 50–100 IU/kg 3 times per week (IV or SC)
Non-dialysis CKD patients: 75–150 IU/kg once or twice a week (SC preferred)
Cancer-related anemia: 150 IU/kg thrice weekly or 40,000 IU once weekly (SC)
Dosage is titrated based on individual response and hemoglobin levels

Method of Administration:

Administered subcutaneously (SC) or intravenously (IV)
To be used under the supervision of a healthcare provider
Rotate subcutaneous injection sites to avoid irritation
Inspect solution for particles or discoloration before use

Precautions:

Do not exceed hemoglobin levels above 12 g/dL
Monitor blood pressure, hemoglobin, and hematocrit regularly
Evaluate iron status; iron supplementation may be necessary
Use cautiously in patients with a history of cardiovascular disease, seizures, or thrombosis
Discontinue if signs of PRCA occur

Drug Interactions:

No major interactions known, but monitor closely if used with:
- Iron supplements – often necessary to support red blood cell production
- Antihypertensive drugs – as erythropoietin can increase blood pressure
- Immunosuppressants – may alter bone marrow response

Allergies:

Contraindicated in patients with known hypersensitivity to erythropoietin or excipients
Allergic reactions may include:
- Rash
- Swelling of lips or throat
- Breathing difficulty
- Severe dizziness or fainting

Overdose Information:

Symptoms: Increased risk of hypertension, stroke, and blood clots
Management: Discontinue treatment and provide supportive care
Therapeutic phlebotomy may be considered if hemoglobin rises excessively

Missed Dose Instructions:

Administer the missed dose as soon as possible
If close to the next scheduled dose, skip the missed one
Never double the dose to make up for a missed dose

Additional Notes:

Treatment may take several weeks for full effect
Regular monitoring of hemoglobin, iron, and blood pressure is crucial
Inform your doctor of any unusual fatigue, shortness of breath, or dizziness
Smoking may reduce treatment efficacy