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Renocrit 6000iu - Erythropoietin Injection

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Renocrit 6000iu - Erythropoietin Injection

Renocrit 6000 IU is a synthetic erythropoietin injection used to treat anemia caused by chronic kidney disease, chemotherapy, or other medical conditions that reduce red blood cell production. It helps the body produce more red blood cells and reduces the need for blood transfusions.

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Description Product Details
General Information:
Generic Name: Erythropoietin
Brand Name: Renocrit
Packing: Pre-filled syringe or vial
Strength: 6000 IU
Manufacturer: Zydus Lifesciences Ltd.
Form: Injection (solution for subcutaneous or intravenous administration)
Category: Hematopoietic Agent / Anti-anemic
Product Intro:
Renocrit 6000 IU is a recombinant human erythropoietin alpha injection, designed to stimulate red blood cell production. It is commonly used in patients with anemia due to chronic kidney disease (CKD), cancer treatments, or other hematological disorders. The injection helps improve energy levels, reduce fatigue, and enhance the overall quality of life in anemic patients.
Uses:
  1. Anemia in chronic kidney disease (CKD) patients
  2. Anemia due to chemotherapy in cancer patients
  3. Anemia in HIV-infected patients receiving zidovudine therapy
  4. To reduce the need for blood transfusions in surgical patients
  5. Anemia associated with bone marrow failure or post-transplant
  6. Supportive therapy in dialysis patients
Storage Instructions:
  1. Store at 2°C to 8°C (refrigerator)
  2. Do not freeze
  3. Keep away from light and heat sources
  4. Do not shake the vial or pre-filled syringe
  5. Keep out of reach of children
How it Works (Mechanism of Action):
Renocrit contains erythropoietin alpha, a man-made form of a natural hormone produced by the kidneys. It stimulates the bone marrow to produce red blood cells, improving oxygen delivery to the body and treating anemia symptoms like fatigue and weakness.
Side Effects:
Common Side Effects:
  1. Headache
  2. Nausea
  3. Fever
  4. Injection site reactions (pain, redness, or swelling)
  5. Joint or muscle pain
  6. Elevated blood pressure
Severe Side Effects:
  1. Thromboembolic events (e.g., deep vein thrombosis, stroke)
  2. Seizures
  3. Pure red cell aplasia (PRCA)
  4. Hypersensitivity reactions, including anaphylaxis
  5. Rapid increase in hemoglobin, which can be dangerous
Dosage (Typical Recommended Dose):
  1. Typically 6000 IU once weekly or as prescribed
  2. Dose may vary depending on patient’s weight, response, and medical condition
  3. Adjustments based on hemoglobin levels and treatment goals
  4. Maximum target hemoglobin: ≤12 g/dL
Method of Administration:
  1. Can be administered subcutaneously (SC) or intravenously (IV)
  2. Injection should be given by a healthcare provider or trained caregiver
  3. Rotate injection sites for SC administration
  4. Allow the solution to come to room temperature before injecting
  5. Use sterile technique and do not reuse needles
Precautions:
  1. Monitor hemoglobin levels regularly
  2. Use with caution in patients with hypertension, epilepsy, or heart disease
  3. Not suitable for patients with uncontrolled high blood pressure
  4. Avoid in patients with a history of PRCA due to erythropoietin therapy
  5. Iron supplementation may be required for better results
Drug Interactions:
  1. No significant interactions reported, but caution with:
    1. Immunosuppressants
    2. Cytotoxic agents
    3. Androgens (may enhance effect)
Always inform your healthcare provider of all current medications.
Allergies:
  1. Contraindicated in patients allergic to erythropoietin or formulation components
  2. Signs of allergic reaction: rash, itching, swelling, dizziness, trouble breathing
  3. Discontinue immediately in case of serious allergic response
Overdose Information:
  1. Overdose may lead to excess red blood cells (polycythemia)
  2. Increases risk of blood clots, stroke, and hypertension
  3. Management involves withholding doses, supportive care, and possibly therapeutic phlebotomy
Missed Dose Instructions:
  1. Administer the missed dose as soon as remembered
  2. If close to the next scheduled dose, skip the missed one
  3. Do not double dose to catch up
  4. Resume the normal dosing schedule
Additional Notes:
  1. Treatment should be supervised by a specialist or healthcare provider
  2. Regular monitoring of hemoglobin, hematocrit, and blood pressure is essential
  3. Supplement with iron, folic acid, or B12 if needed
  4. Not for emergency correction of severe anemia
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