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Veenat 400mg - Imatinib Tablet

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Veenat 400mg - Imatinib Tablet

Veenat 400mg is an oral anticancer medication containing Imatinib Mesylate, primarily used to treat Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST). It acts by inhibiting abnormal tyrosine kinase enzymes that drive cancer cell proliferation.

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Description Product Details
General Information:
Generic Name: Imatinib Mesylate
Brand Name: Veenat
Packing: Blister strip (commonly 10 tablets per strip)
Strength: 400 mg
Manufacturer: Natco Pharma Ltd.
Form: Film-coated oral tablet
Category: Anticancer Drug, Tyrosine Kinase Inhibitor (TKI)
Product Intro:
Veenat 400mg is a well-known brand of Imatinib Mesylate produced by Natco Pharma Ltd. It is widely used in the management of various cancers by blocking specific proteins responsible for the abnormal growth and spread of cancerous cells. As a targeted therapy, it offers a more focused approach to cancer treatment compared to traditional chemotherapy.
Uses:
  1. Chronic Myeloid Leukemia (CML) – Philadelphia chromosome-positive
  2. Gastrointestinal Stromal Tumors (GIST)
  3. Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
  4. Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
  5. Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL)
  6. Systemic Mastocytosis
  7. Dermatofibrosarcoma Protuberans (DFSP)
Storage Instructions:
  1. Store at a controlled room temperature: 15°C to 30°C
  2. Keep away from direct sunlight and moisture
  3. Store in original packaging until ready to use
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Imatinib inhibits the BCR-ABL tyrosine kinase, which is produced by the abnormal Philadelphia chromosome in CML.
  1. It also blocks c-KIT and PDGFR tyrosine kinases involved in GIST and other malignancies.
  2. By inhibiting these kinases, it stops cancer cell growth and induces apoptosis (programmed cell death).
Side Effects:
Common Side Effects:
  1. Nausea, vomiting
  2. Diarrhea
  3. Swelling (edema), especially around eyes and ankles
  4. Fatigue
  5. Muscle cramps
  6. Skin rash
  7. Abdominal discomfort
Serious Side Effects:
  1. Bone marrow suppression (low blood counts)
  2. Liver toxicity
  3. Fluid retention in the lungs (pleural effusion)
  4. Heart failure (rare)
  5. Severe allergic reactions or skin conditions
  6. Gastrointestinal bleeding
  7. Infections due to low white cell count
Dosage (Typical Recommended Dose):
  1. CML (Chronic Phase): 400 mg once daily
  2. CML (Advanced Phase/Blast Crisis): 600 mg once daily
  3. GIST: 400–600 mg once daily depending on clinical response
  4. Dosage can be modified depending on patient’s response and tolerance
Method of Administration:
  1. Take orally with a glass of water
  2. Administer with food to minimize gastric irritation
  3. Swallow the tablet whole – do not crush or chew
  4. Take at the same time every day for best results
Precautions:
  1. Regular monitoring of blood counts, liver and kidney functions
  2. Use with caution in patients with cardiac or hepatic impairments
  3. Not recommended during pregnancy or breastfeeding
  4. Use effective contraception during treatment
  5. Avoid alcohol and grapefruit juice as they may interfere with drug metabolism
Drug Interactions:
  1. CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase Imatinib levels
  2. CYP3A4 inducers (e.g., rifampin, phenytoin) may decrease drug levels
  3. May interact with acetaminophen, warfarin, antifungals, and some antibiotics
  4. Caution when used with cardiovascular drugs
Allergies:
  1. Contraindicated in patients with a known hypersensitivity to Imatinib or any excipients
  2. Allergic reactions may include rash, itching, swelling, dizziness, or difficulty breathing
Overdose Information:
  1. Symptoms: nausea, vomiting, abdominal pain, edema, and liver dysfunction
  2. In the event of overdose, seek emergency medical help immediately
  3. No specific antidote – treatment is supportive
Missed Dose Instructions:
  1. Take the missed dose as soon as possible
  2. Skip it if it's almost time for the next scheduled dose
  3. Do not take a double dose to make up for the missed one
Additional Notes:
  1. Do not stop treatment without your doctor’s advice
  2. Keep a consistent schedule and do not share your medication
  3. Inform all healthcare providers that you're on Imatinib, especially before surgeries or new prescriptions
  4. Maintain hydration and nutrition, and monitor for signs of infection or unusual bleeding
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