Product Introduction:
Zybiraa 500 mg is an oral anti-cancer medication used in the treatment of advanced-stage prostate cancer. It is most effective for metastatic castration-resistant prostate cancer (mCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC).
Since prostate cancer cells rely on androgens (male hormones) to grow, Zybiraa blocks androgen production at multiple sites, including the adrenal glands, testes, and tumors. It is always used in combination with prednisone to prevent side effects like high blood pressure and fluid retention.
Uses of Zybiraa 500 mg
Zybiraa is mainly used to treat advanced prostate cancer. The primary conditions it treats include:
-
Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Used when the cancer has spread and does not respond to hormone therapy.
-
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – Combined with prednisone to enhance survival rates.
-
Prostate Cancer Progression Control – Reduces tumor growth by decreasing androgen levels.
-
Delaying Chemotherapy Requirement – Helps patients avoid or delay chemotherapy.
-
Post-Surgical Treatment for Prostate Cancer – Sometimes prescribed after surgery to prevent recurrence.
How Zybiraa 500 mg Works (Mechanism of Action):
Zybiraa (Abiraterone Acetate) is a CYP17 inhibitor that blocks the production of androgens (male hormones), which are essential for the growth of prostate cancer cells.
-
Inhibits the CYP17 enzyme, which plays a crucial role in testosterone production.
-
Prevents the conversion of pregnenolone and progesterone into testosterone in the adrenal glands, testes, and tumor cells.
-
Lowers androgen levels, slowing cancer progression and reducing tumor size.
Since Abiraterone disrupts the body's hormonal balance, prednisone is prescribed alongside it to help maintain stability and prevent complications.
Dosage of Zybiraa 500 mg
Recommended Dosage:
-
Standard Dose: 1000 mg (500 mg two tablets) once daily
-
Taken with prednisone: Usually 5 mg twice daily
-
Doctor may adjust the dose based on patient response and side effects.
For patients with liver problems:
-
Dose adjustments may be required based on liver function tests.
Method of Administration (How to Take It)
-
Take Zybiraa on an empty stomach, at least 1 hour before or 2 hours after a meal.
-
Swallow the tablets whole with a full glass of water.
-
Do not chew, crush, or break the tablets.
-
Take it at the same time every day for best results.
-
Prednisone is required alongside Zybiraa to balance hormone levels and reduce side effects.
Side Effects of Zybiraa 500 mg
Common Side Effects:
-
Fatigue & Weakness
-
High blood pressure (Hypertension)
-
Swelling in legs or feet (Fluid retention/Edema)
-
Low potassium levels (Hypokalemia)
-
Hot flashes
-
Increased liver enzymes
-
Joint pain (Arthralgia)
Severe Side Effects:
-
Heart problems (Arrhythmias, Heart failure)
-
Severe liver damage (Hepatotoxicity)
-
Adrenal insufficiency
-
Severe allergic reactions (Rash, swelling, difficulty breathing)
⚠️ Contact a doctor if you experience serious side effects like severe dizziness, chest pain, or yellowing of the skin (jaundice).
Precautions Before Taking Zybiraa 500 mg
-
Not for use in women or children – Can cause severe harm if used by pregnant women.
-
Monitor blood pressure and liver function regularly.
-
Caution in heart disease patients – May increase the risk of heart complications.
-
Avoid grapefruit or grapefruit juice – It may enhance side effects.
-
Use effective contraception – Can be harmful if a male patient’s partner is pregnant.
Drug Interactions (Medications That May Interact)
Zybiraa 500 mg can interact with several medications:
Avoid using with:
-
Strong CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce effectiveness.
-
CYP2D6 substrates (e.g., Metoprolol, Codeine) – Can alter drug levels.
-
Blood thinners (Warfarin, Heparin) – May increase bleeding risk.
-
Corticosteroids (other than prednisone) – Can cause hormonal imbalances.
-
Heart medications (Digoxin, Amiodarone) – Risk of cardiac complications.
Allergy Warnings
-
Do not use if allergic to Abiraterone Acetate or any ingredients in Zybiraa.
-
Signs of allergy: Rash, swelling, severe itching, difficulty breathing.
-
Seek medical help immediately if an allergic reaction occurs.
Storage Instructions
-
Store at room temperature (15-30°C or 59-86°F).
-
Keep in a dry place, away from moisture and heat.
-
Keep out of reach of children.
-
Do not use expired medication.
Overdose Information
Symptoms of overdose:
-
Severe dizziness or fainting
-
Irregular heartbeat
-
Confusion or trouble breathing
What to do in case of overdose?
-
Seek emergency medical help immediately.
-
Contact a poison control center or go to the nearest hospital.
Missed Dose Instructions
-
If you miss a dose, take it as soon as you remember.
-
If it is almost time for the next dose, skip the missed dose—do not double the dose.
-
Never take extra tablets to make up for a missed dose.
Additional Notes:
-
Regular blood tests are required to monitor potassium levels, liver function, and blood pressure.
-
Do not stop taking the medication suddenly without consulting a doctor.
-
Follow a healthy lifestyle with a balanced diet and exercise for better results.
