Product Introduction:
Chemotinib 400mg contains Imatinib Mesylate, a first-generation tyrosine kinase inhibitor (TKI) that revolutionized the treatment of certain cancers by directly targeting the genetic drivers of the disease. It is most commonly prescribed for CML and GIST and is taken orally once daily under medical supervision.
Uses:
Chemotinib 400mg is used to treat:
-
Chronic Myeloid Leukemia (CML) – all phases (chronic, accelerated, blast crisis)
-
Acute Lymphoblastic Leukemia (ALL) – Philadelphia chromosome-positive (Ph+)
-
Gastrointestinal Stromal Tumors (GIST) – unresectable or metastatic
-
Myelodysplastic/Myeloproliferative Diseases (MDS/MPD) – with PDGFR gene rearrangements
-
Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL)
-
Dermatofibrosarcoma Protuberans (DFSP) – unresectable or metastatic
Storage Instructions:
-
Store below 30°C, away from direct light and moisture
-
Keep in original packaging until use
-
Keep out of reach of children
-
Do not use expired or damaged tablets
How It Works (Mechanism of Action):
Imatinib selectively inhibits specific tyrosine kinases, including BCR-ABL (in CML), c-KIT (in GIST), and PDGFR. These kinases are responsible for uncontrolled cell division in cancers. By blocking these signals, Imatinib slows or stops cancer cell proliferation and leads to apoptosis (programmed cell death) in malignant cells.
Side Effects:
Common side effects:
-
Nausea, vomiting
-
Muscle cramps and joint pain
-
Fatigue
-
Edema (especially around eyes and ankles)
-
Diarrhea or constipation
-
Skin rash
Severe side effects (may require medical attention):
-
Severe fluid retention (e.g., pleural or pericardial effusion)
-
Liver enzyme elevation
-
Low blood counts (anemia, neutropenia, thrombocytopenia)
-
Congestive heart failure (rare)
-
Severe skin reactions or allergic responses
Dosage (Typical Recommended Dose):
-
CML and GIST (adult): 400 mg to 600 mg once daily
-
Dose may be adjusted based on response or tolerance
-
Take at the same time each day, with food and a full glass of water
-
Pediatric and off-label dosages vary as per doctor’s guidance
Method of Administration:
-
Oral use only
-
Swallow tablet whole with food to reduce stomach upset
-
Do not crush, chew, or break
-
Drink plenty of fluids unless advised otherwise
Precautions:
-
Regular blood tests and liver function monitoring required
-
Use caution in patients with heart, liver, or kidney disorders
-
Not recommended during pregnancy unless necessary – may cause fetal harm
-
Use effective contraception during and after treatment
-
Avoid grapefruit juice, as it may increase Imatinib levels in the body
Drug Interactions:
-
Interacts with CYP3A4 inhibitors/inducers (e.g., ketoconazole, rifampin, phenytoin)
-
May affect the levels of warfarin, simvastatin, cyclosporine, and other drugs
-
Always consult your doctor before combining with other medications or herbal products
Allergies:
-
Contraindicated in individuals with known hypersensitivity to Imatinib or excipients
-
Seek immediate care if symptoms like rash, swelling, difficulty breathing, or dizziness occur
Overdose Information:
-
Symptoms may include severe nausea, vomiting, abdominal pain, fluid retention, or liver toxicity
-
No specific antidote – hospitalization and supportive care required
-
Contact emergency services or poison control immediately if overdose is suspected
Missed Dose Instructions:
-
Take the missed dose as soon as you remember on the same day
-
If it's almost time for the next dose, skip the missed dose – do not double up
-
Maintain a regular dosing schedule for best results
Additional Notes:
-
Response to Chemotinib is often monitored via molecular tests (e.g., BCR-ABL transcript levels)
-
May be used long-term depending on disease stage and treatment goals
-
Educate patients on adherence, possible side effects, and when to seek help
-
Participation in routine follow-ups and lab testing is essential for safe use
Product Introduction:
Chemotinib 400mg contains Imatinib Mesylate, a first-generation tyrosine kinase inhibitor (TKI) that revolutionized the treatment of certain cancers by directly targeting the genetic drivers of the disease. It is most commonly prescribed for CML and GIST and is taken orally once daily under medical supervision.
Uses:
Chemotinib 400mg is used to treat:
-
Chronic Myeloid Leukemia (CML) – all phases (chronic, accelerated, blast crisis)
-
Acute Lymphoblastic Leukemia (ALL) – Philadelphia chromosome-positive (Ph+)
-
Gastrointestinal Stromal Tumors (GIST) – unresectable or metastatic
-
Myelodysplastic/Myeloproliferative Diseases (MDS/MPD) – with PDGFR gene rearrangements
-
Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL)
-
Dermatofibrosarcoma Protuberans (DFSP) – unresectable or metastatic
Storage Instructions:
-
Store below 30°C, away from direct light and moisture
-
Keep in original packaging until use
-
Keep out of reach of children
-
Do not use expired or damaged tablets
How It Works (Mechanism of Action):
Imatinib selectively inhibits specific tyrosine kinases, including BCR-ABL (in CML), c-KIT (in GIST), and PDGFR. These kinases are responsible for uncontrolled cell division in cancers. By blocking these signals, Imatinib slows or stops cancer cell proliferation and leads to apoptosis (programmed cell death) in malignant cells.
Side Effects:
Common side effects:
-
Nausea, vomiting
-
Muscle cramps and joint pain
-
Fatigue
-
Edema (especially around eyes and ankles)
-
Diarrhea or constipation
-
Skin rash
Severe side effects (may require medical attention):
-
Severe fluid retention (e.g., pleural or pericardial effusion)
-
Liver enzyme elevation
-
Low blood counts (anemia, neutropenia, thrombocytopenia)
-
Congestive heart failure (rare)
-
Severe skin reactions or allergic responses
Dosage (Typical Recommended Dose):
-
CML and GIST (adult): 400 mg to 600 mg once daily
-
Dose may be adjusted based on response or tolerance
-
Take at the same time each day, with food and a full glass of water
-
Pediatric and off-label dosages vary as per doctor’s guidance
Method of Administration:
-
Oral use only
-
Swallow tablet whole with food to reduce stomach upset
-
Do not crush, chew, or break
-
Drink plenty of fluids unless advised otherwise
Precautions:
-
Regular blood tests and liver function monitoring required
-
Use caution in patients with heart, liver, or kidney disorders
-
Not recommended during pregnancy unless necessary – may cause fetal harm
-
Use effective contraception during and after treatment
-
Avoid grapefruit juice, as it may increase Imatinib levels in the body
Drug Interactions:
-
Interacts with CYP3A4 inhibitors/inducers (e.g., ketoconazole, rifampin, phenytoin)
-
May affect the levels of warfarin, simvastatin, cyclosporine, and other drugs
-
Always consult your doctor before combining with other medications or herbal products
Allergies:
-
Contraindicated in individuals with known hypersensitivity to Imatinib or excipients
-
Seek immediate care if symptoms like rash, swelling, difficulty breathing, or dizziness occur
Overdose Information:
-
Symptoms may include severe nausea, vomiting, abdominal pain, fluid retention, or liver toxicity
-
No specific antidote – hospitalization and supportive care required
-
Contact emergency services or poison control immediately if overdose is suspected
Missed Dose Instructions:
-
Take the missed dose as soon as you remember on the same day
-
If it's almost time for the next dose, skip the missed dose – do not double up
-
Maintain a regular dosing schedule for best results
Additional Notes:
-
Response to Chemotinib is often monitored via molecular tests (e.g., BCR-ABL transcript levels)
-
May be used long-term depending on disease stage and treatment goals
-
Educate patients on adherence, possible side effects, and when to seek help
-
Participation in routine follow-ups and lab testing is essential for safe use
