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Imatirel 400mg - Imatinib Tablet

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Imatirel 400mg - Imatinib Tablet

Imatirel 400mg is an oral anticancer medication used for treating Chronic Myeloid Leukemia (CML), Gastrointestinal Stromal Tumors (GIST), and other cancers. It works by inhibiting abnormal tyrosine kinases that stimulate cancer cell growth.

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Description Product Details
General Information:
Generic Name: Imatinib Mesylate
Brand Name: Imatirel
Packing: Strip/Bottle (commonly 10 tablets per strip)
Strength: 400 mg
Manufacturer: Reliance Life Sciences
Form: Film-coated oral tablet
Category: Anticancer, Tyrosine Kinase Inhibitor (TKI)
Product Intro:
Imatirel 400mg is a generic version of Imatinib Mesylate, developed for the effective treatment of blood-related and soft tissue cancers. Manufactured by Reliance Life Sciences, it belongs to a class of medicines known as Tyrosine Kinase Inhibitors (TKIs). It is specifically formulated to block signals within cancer cells that cause them to grow and divide uncontrollably.
Uses:
  1. Chronic Myeloid Leukemia (CML) – particularly Philadelphia chromosome positive
  2. Gastrointestinal Stromal Tumors (GIST)
  3. Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
  4. Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
  5. Hypereosinophilic Syndrome (HES)
  6. Systemic Mastocytosis
  7. Dermatofibrosarcoma Protuberans (DFSP)
Storage Instructions:
  1. Store at a temperature between 15°C and 30°C
  2. Keep away from direct light, heat, and moisture
  3. Store in a tightly closed container
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Imatinib targets and inhibits BCR-ABL tyrosine kinase, the abnormal protein responsible for the uncontrolled growth of white blood cells in CML.
  1. It also inhibits c-KIT and PDGF receptors, which are involved in the growth of GIST and other tumors.
  2. This leads to reduced proliferation and survival of cancer cells, slowing or stopping the disease.
Side Effects:
Common Side Effects:
  1. Nausea and vomiting
  2. Fluid retention (swelling of hands, ankles)
  3. Muscle cramps and joint pain
  4. Fatigue
  5. Diarrhea
  6. Skin rash
  7. Headache
Severe Side Effects:
  1. Bone marrow suppression (low blood cell counts)
  2. Liver toxicity
  3. Heart issues (rare)
  4. Severe skin reactions (Stevens-Johnson Syndrome)
  5. Gastrointestinal bleeding
  6. Tumor lysis syndrome
Dosage (Typical Recommended Dose):
  1. CML (Chronic Phase): 400 mg once daily
  2. CML (Advanced Phase or Blast Crisis): 600 mg once daily
  3. GIST: 400–600 mg once daily depending on severity
  4. Dosage adjustments are made based on response and tolerability
Method of Administration:
  1. Taken orally, once daily
  2. Should be taken with food and a large glass of water
  3. Swallow the tablet whole – do not crush or chew
  4. Take at the same time each day
Precautions:
  1. Monitor complete blood count, liver function, and kidney function regularly
  2. Use cautiously in patients with cardiac, hepatic, or renal impairment
  3. Not recommended during pregnancy or breastfeeding
  4. Avoid alcohol and grapefruit juice
  5. Patients should use effective contraception
Drug Interactions:
  1. Avoid with CYP3A4 inhibitors like ketoconazole, clarithromycin
  2. Avoid with CYP3A4 inducers like rifampin, carbamazepine – may reduce Imatinib levels
  3. Interacts with acetaminophen, warfarin, antifungal medications
  4. May increase side effects of cyclosporine or simvastatin
Allergies:
  1. Do not use if allergic to Imatinib or any of its ingredients
  2. Watch for symptoms like hives, rash, shortness of breath, or swelling
Overdose Information:
  1. Symptoms may include vomiting, diarrhea, drowsiness, swelling, and liver dysfunction
  2. In case of overdose, seek emergency medical help immediately
  3. No specific antidote; supportive care is essential
Missed Dose Instructions:
  1. Take the missed dose as soon as remembered
  2. Skip if close to the time for the next dose
  3. Do not double the dose to make up for a missed one
Additional Notes:
  1. Regular blood monitoring is crucial during therapy
  2. Avoid contact with people who are sick due to lowered immunity
  3. Report signs of bleeding, infection, or unusual tiredness to your doctor
  4. Long-term therapy may be required depending on disease status
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