Product Introduction:
Merosearch 1gm contains Meropenem, a potent beta-lactam antibiotic with high activity against gram-positive, gram-negative, and anaerobic bacteria. It is typically reserved for moderate to severe infections where other antibiotics are ineffective, including multi-drug resistant (MDR) organisms. It is administered through intravenous infusion by a healthcare professional.
Uses:
Merosearch 1gm is used for the treatment of:
-
Complicated intra-abdominal infections
-
Bacterial meningitis
-
Severe skin and soft tissue infections
-
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP)
-
Urinary tract infections (including pyelonephritis)
-
Sepsis and bloodstream infections
-
Febrile neutropenia (as empirical treatment)
-
Infections caused by multi-drug resistant bacteria
Storage Instructions:
-
Store below 25°C
-
Protect from light and moisture
-
Do not freeze the reconstituted solution
-
Use the solution immediately after reconstitution or within the specified time per guidelines
-
Keep out of reach of children
How It Works (Mechanism of Action):
Meropenem works by inhibiting bacterial cell wall synthesis, specifically by binding to penicillin-binding proteins (PBPs). This leads to cell lysis and death of susceptible bacteria. Its broad spectrum and stability against most beta-lactamases make it effective against a wide variety of bacterial pathogens, including ESBL-producing organisms.
Side Effects:
Common side effects include:
-
Diarrhea
-
Nausea or vomiting
-
Headache
-
Injection site inflammation or pain
-
Rash
Serious side effects may include:
-
Severe allergic reactions (anaphylaxis)
-
Seizures (especially in patients with CNS disorders)
-
Clostridium difficile-associated diarrhea
-
Liver enzyme elevation
-
Blood dyscrasias (low WBC or platelets)
Dosage (Typical Recommended Dose):
-
Adults: Usually 500mg to 1g every 8 hours, depending on infection severity and renal function
-
Meningitis or severe infections: 2g every 8 hours may be used
-
Children: Dosage is weight-based (typically 20–40 mg/kg every 8 hours)
-
Dose must be adjusted in renal impairment
Method of Administration:
-
Administered via intravenous infusion (IV) over 15 to 30 minutes, or as an IV bolus over 3 to 5 minutes
-
Must be reconstituted with sterile water or compatible IV fluid (e.g., saline) before administration
-
Given only by healthcare professionals in a hospital or clinical setting
Precautions:
-
Use with caution in patients with a history of seizures or CNS disorders
-
Regular monitoring of renal function is required, especially in the elderly or those with kidney impairment
-
Avoid prolonged use to reduce risk of superinfection or resistance
-
Not recommended in pregnancy or breastfeeding unless clearly needed
-
Do not use if there's a known allergy to carbapenems, penicillins, or cephalosporins
Drug Interactions:
May interact with:
-
Valproic acid – may reduce serum levels, increasing seizure risk
-
Probenecid – may increase meropenem levels by decreasing renal excretion
-
Other antibiotics – combined use should be monitored for synergy or antagonism
-
Anticoagulants – monitor for changes in INR or bleeding risk
Allergies:
-
Contraindicated in patients with known hypersensitivity to Meropenem or other beta-lactam antibiotics
-
Signs of allergic reaction: rash, itching, swelling, difficulty breathing, anaphylaxis – seek emergency care immediately
Overdose Information:
-
Symptoms: Seizures, confusion, renal dysfunction, or neurological symptoms
-
Treatment: Supportive care, possible hemodialysis to remove excess drug
-
In case of suspected overdose, seek urgent medical attention
Missed Dose Instructions:
-
Since it's administered in a clinical setting, missed doses are unlikely
-
If a dose is missed, it should be administered as soon as possible, unless it’s close to the next scheduled dose
-
Do not double the dose
Additional Notes:
-
Monitor white blood cell counts, renal function, and liver enzymes during prolonged therapy
-
Consider stool testing if severe or prolonged diarrhea occurs
-
Use of Meropenem should be guided by culture and sensitivity tests whenever possible
-
Always complete the entire course of treatment even if symptoms improve early
Product Introduction:
Merosearch 1gm contains Meropenem, a potent beta-lactam antibiotic with high activity against gram-positive, gram-negative, and anaerobic bacteria. It is typically reserved for moderate to severe infections where other antibiotics are ineffective, including multi-drug resistant (MDR) organisms. It is administered through intravenous infusion by a healthcare professional.
Uses:
Merosearch 1gm is used for the treatment of:
-
Complicated intra-abdominal infections
-
Bacterial meningitis
-
Severe skin and soft tissue infections
-
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP)
-
Urinary tract infections (including pyelonephritis)
-
Sepsis and bloodstream infections
-
Febrile neutropenia (as empirical treatment)
-
Infections caused by multi-drug resistant bacteria
Storage Instructions:
-
Store below 25°C
-
Protect from light and moisture
-
Do not freeze the reconstituted solution
-
Use the solution immediately after reconstitution or within the specified time per guidelines
-
Keep out of reach of children
How It Works (Mechanism of Action):
Meropenem works by inhibiting bacterial cell wall synthesis, specifically by binding to penicillin-binding proteins (PBPs). This leads to cell lysis and death of susceptible bacteria. Its broad spectrum and stability against most beta-lactamases make it effective against a wide variety of bacterial pathogens, including ESBL-producing organisms.
Side Effects:
Common side effects include:
-
Diarrhea
-
Nausea or vomiting
-
Headache
-
Injection site inflammation or pain
-
Rash
Serious side effects may include:
-
Severe allergic reactions (anaphylaxis)
-
Seizures (especially in patients with CNS disorders)
-
Clostridium difficile-associated diarrhea
-
Liver enzyme elevation
-
Blood dyscrasias (low WBC or platelets)
Dosage (Typical Recommended Dose):
-
Adults: Usually 500mg to 1g every 8 hours, depending on infection severity and renal function
-
Meningitis or severe infections: 2g every 8 hours may be used
-
Children: Dosage is weight-based (typically 20–40 mg/kg every 8 hours)
-
Dose must be adjusted in renal impairment
Method of Administration:
-
Administered via intravenous infusion (IV) over 15 to 30 minutes, or as an IV bolus over 3 to 5 minutes
-
Must be reconstituted with sterile water or compatible IV fluid (e.g., saline) before administration
-
Given only by healthcare professionals in a hospital or clinical setting
Precautions:
-
Use with caution in patients with a history of seizures or CNS disorders
-
Regular monitoring of renal function is required, especially in the elderly or those with kidney impairment
-
Avoid prolonged use to reduce risk of superinfection or resistance
-
Not recommended in pregnancy or breastfeeding unless clearly needed
-
Do not use if there's a known allergy to carbapenems, penicillins, or cephalosporins
Drug Interactions:
May interact with:
-
Valproic acid – may reduce serum levels, increasing seizure risk
-
Probenecid – may increase meropenem levels by decreasing renal excretion
-
Other antibiotics – combined use should be monitored for synergy or antagonism
-
Anticoagulants – monitor for changes in INR or bleeding risk
Allergies:
-
Contraindicated in patients with known hypersensitivity to Meropenem or other beta-lactam antibiotics
-
Signs of allergic reaction: rash, itching, swelling, difficulty breathing, anaphylaxis – seek emergency care immediately
Overdose Information:
-
Symptoms: Seizures, confusion, renal dysfunction, or neurological symptoms
-
Treatment: Supportive care, possible hemodialysis to remove excess drug
-
In case of suspected overdose, seek urgent medical attention
Missed Dose Instructions:
-
Since it's administered in a clinical setting, missed doses are unlikely
-
If a dose is missed, it should be administered as soon as possible, unless it’s close to the next scheduled dose
-
Do not double the dose
Additional Notes:
-
Monitor white blood cell counts, renal function, and liver enzymes during prolonged therapy
-
Consider stool testing if severe or prolonged diarrhea occurs
-
Use of Meropenem should be guided by culture and sensitivity tests whenever possible
-
Always complete the entire course of treatment even if symptoms improve early
