Product Introduction:
Acaone 100 mg is a next-generation BTK inhibitor designed to treat B-cell cancers, such as leukemia and lymphoma. It works by selectively blocking the Bruton’s tyrosine kinase (BTK) protein, which plays a crucial role in cancer cell survival. Compared to older BTK inhibitors like Ibrutinib, Acalabrutinib has fewer side effects and better selectivity.
Uses of Acaone 100 mg
Acaone 100 mg is used to treat the following types of blood cancer:
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Chronic Lymphocytic Leukemia (CLL) – A common type of leukemia in adults affecting B-lymphocytes.
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Small Lymphocytic Lymphoma (SLL) – A slow-growing non-Hodgkin lymphoma affecting lymph nodes and bone marrow.
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Mantle Cell Lymphoma (MCL) – Used in patients who have received prior therapy.
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Waldenström’s Macroglobulinemia (WM) – A rare type of lymphoma that affects plasma cells. (Investigational use)
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Other Non-Hodgkin’s Lymphomas (NHL) – Under research for more lymphoma types.
How Acaone 100 mg Works (Mechanism of Action):
Acaone 100 mg (Acalabrutinib) works by:
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Inhibiting Bruton’s Tyrosine Kinase (BTK), a protein required for cancerous B-cells to grow.
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Blocking cancer cell signaling, preventing their survival and spread.
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Reducing tumor growth, slowing disease progression.
Since Acalabrutinib is more selective than older BTK inhibitors, it reduces side effects related to off-target activity.
Dosage of Acaone 100 mg
Recommended Dosage:
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Standard Dose: 100 mg twice daily (every 12 hours)
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Duration: Continued until disease progression or unacceptable toxicity
Dosage Adjustments:
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If severe side effects (e.g., bleeding, infections, heart issues) occur, the dose may be reduced or stopped temporarily.
Method of Administration (How to Take It)
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Take Acaone 100 mg orally with water.
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Do not chew, crush, or open the capsule.
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Take at the same time every day for best results.
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Avoid grapefruit or grapefruit juice, as they interfere with absorption.
Side Effects of Acaone 100 mg
Common Side Effects:
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Fatigue and weakness
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Headache (very common)
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Diarrhea, nausea
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Bruising or bleeding easily
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Upper respiratory tract infections (cough, fever, runny nose)
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Low blood counts (neutropenia, anemia, thrombocytopenia)
Severe Side Effects:
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Severe Bleeding (Hemorrhage) – Unusual bruising, prolonged bleeding, internal bleeding.
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Infections (Bacterial, Viral, or Fungal) – Fever, chills, difficulty breathing.
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Atrial Fibrillation (Irregular Heartbeat) – Dizziness, palpitations, chest pain.
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Severe Liver Toxicity (Hepatitis, Jaundice) – Yellowing of skin/eyes, dark urine.
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Secondary Malignancies (Skin Cancer, Other Cancers) – Regular skin checks are recommended.
⚠️ Seek immediate medical help for severe bleeding, infection, or heart issues.
Precautions Before Taking Acaone 100 mg
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Not safe during pregnancy or breastfeeding – Can cause fetal harm.
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Frequent blood tests needed – To monitor blood counts and liver function.
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Avoid live vaccines – Higher infection risk.
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Caution in patients with heart disease – May increase risk of atrial fibrillation.
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Use contraception during and after treatment – To prevent birth defects.
Drug Interactions (Medications That May Interact)
Acaone 100 mg can interact with several drugs:
Avoid using with:
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CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce effectiveness.
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CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir) – May increase toxicity.
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Blood thinners (Warfarin, Heparin, Aspirin) – Increased bleeding risk.
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Proton Pump Inhibitors (PPIs like Omeprazole, Esomeprazole) – May reduce drug absorption.
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Antibiotics (Clarithromycin, Erythromycin) – May require dose adjustments.
Allergy Warnings
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Do not use if allergic to Acalabrutinib or any capsule ingredients.
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Symptoms of an allergic reaction: Rash, swelling, severe itching, difficulty breathing.
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Seek emergency help if an allergic reaction occurs.
Storage Instructions
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Store at room temperature (15-30°C or 59-86°F).
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Keep in a dry place, away from moisture and sunlight.
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Keep out of reach of children.
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Do not use expired capsules.
Overdose Information
Symptoms of overdose:
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Severe headache
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Uncontrollable bleeding
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Extreme dizziness or fainting
What to do in case of overdose?
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Seek emergency medical help immediately.
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Visit the nearest hospital or call a poison control center.
Missed Dose Instructions
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If you miss a dose, take it as soon as you remember.
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If it is less than 4 hours before your next dose, skip the missed dose—do not take a double dose.
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Never take extra capsules to make up for a missed dose.
Additional Notes:
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Regular monitoring is required for blood counts, liver function, and heart health.
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Report unusual bruising, bleeding, or infections immediately to your doctor.
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Do not stop taking Acaone suddenly without medical advice.
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Wear sunscreen and protective clothing to reduce the risk of skin cancer.
