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Ahabir 250mg - Abiraterone Acetate Tablets

Ahabir 250 mg is an anti-cancer medication used to treat advanced prostate cancer (metastatic prostate cancer). It contains Abiraterone Acetate, which reduces androgen (male hormone) production, helping to slow the growth of cancer cells. This medication is always prescribed with prednisone to manage side effects and improve treatment outcomes.

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General Information:
Generic Name: Abiraterone Acetate
Brand Name: Ahabir 250 mg
Packing: Bottles containing 120 tablets
Strength: 250 mg per tablet
Manufacturer: Hetero Healthcare Limited
Form: Oral Tablets
Category: Anti-Cancer Drug (Hormonal Therapy)
Product Introduction:
Ahabir 250 mg is a hormonal therapy drug used to treat advanced-stage prostate cancer, particularly in cases where the disease has spread to other organs. Since prostate cancer depends on testosterone for growth, Ahabir helps by blocking testosterone production, thus slowing or stopping the spread of cancer cells.
It is usually prescribed in combination with prednisone to counteract potential hormonal imbalances and side effects such as high blood pressure and fluid retention.

Uses of Ahabir 250 mg
Ahabir is primarily used for prostate cancer treatment in the following conditions:
  1. Metastatic Castration-Resistant Prostate Cancer (mCRPC) – When cancer continues to grow despite hormonal therapy or surgical castration.
  2. Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – Helps slow disease progression and improve survival in newly diagnosed advanced cases.
  3. Delaying Chemotherapy – Helps patients avoid or postpone chemotherapy in advanced prostate cancer.
  4. Post-Surgical Treatment – Used to reduce the risk of cancer recurrence after surgery.
  5. Prostate Cancer Symptom Management – Helps alleviate pain, discomfort, and urinary issues caused by tumor growth.

How Ahabir 250 mg Works (Mechanism of Action):
Ahabir (Abiraterone Acetate) is a CYP17 enzyme inhibitor that works by blocking the production of androgens (testosterone and related hormones).
  1. Inhibits the CYP17 enzyme, which is essential for testosterone synthesis.
  2. Reduces androgen production in the testes, adrenal glands, and prostate cancer cells.
  3. Slows down tumor growth by depriving cancer cells of testosterone.
  4. Used with prednisone to counteract side effects such as increased blood pressure and fluid retention.

Dosage of Ahabir 250 mg
Recommended Dosage:
  1. Standard Dose: 1000 mg per day (Four 250 mg tablets taken once daily)
  2. Prednisone Required: 5 mg twice daily
  3. Dose Adjustments: May be needed for patients with liver problems or severe side effects.
Dosage Adjustments for Liver Issues:
  1. Patients with moderate liver impairment may need a lower dose.
  2. Regular liver function tests are necessary to prevent toxicity.

Method of Administration (How to Take It)
  1. Take Ahabir on an empty stomach – at least 1 hour before or 2 hours after a meal.
  2. Swallow the tablet whole with a full glass of water.
  3. Do not chew, crush, or break the tablet before swallowing.
  4. Take the medication at the same time each day to maintain consistent drug levels.
  5. Prednisone must be taken along with Ahabir to reduce side effects.

Side Effects of Ahabir 250 mg
Common Side Effects:
  1. Fatigue & Weakness
  2. High blood pressure (Hypertension)
  3. Swelling in legs or feet (Fluid retention/Edema)
  4. Low potassium levels (Hypokalemia)
  5. Hot flashes & excessive sweating
  6. Increased liver enzyme levels
  7. Joint pain (Arthralgia)
Severe Side Effects:
  1. Heart problems (Irregular heartbeat, Chest pain, Heart failure)
  2. Severe liver damage (Jaundice, Hepatitis, Elevated liver enzymes)
  3. Adrenal insufficiency (Dizziness, Weakness, Low blood pressure, Salt imbalance)
  4. Severe allergic reactions (Rash, Itching, Swelling, Difficulty breathing)
⚠️ Seek immediate medical attention if you experience severe dizziness, chest pain, or yellowing of the skin (jaundice).

Precautions Before Taking Ahabir 250 mg
  1. Not for use in women or children – Can cause serious harm if taken by pregnant women.
  2. Regular blood tests are necessary to monitor liver function, blood pressure, and potassium levels.
  3. Patients with heart disease should use caution – Risk of heart complications.
  4. Avoid grapefruit or grapefruit juice – It can increase the risk of side effects.
  5. Use contraception – Male patients should take precautions to prevent pregnancy in their partners.

Drug Interactions (Medications That May Interact)
Ahabir 250 mg can interact with several medications, including:
Avoid using with:
  1. Strong CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce effectiveness.
  2. CYP2D6 substrates (e.g., Metoprolol, Codeine) – Can alter drug levels.
  3. Blood thinners (Warfarin, Heparin) – May increase the risk of bleeding.
  4. Corticosteroids (other than prednisone) – Can disrupt hormone balance.
  5. Heart medications (Digoxin, Amiodarone) – Can cause heart complications.

Allergy Warnings
  1. Do not use if allergic to Abiraterone Acetate or any ingredients in Ahabir.
  2. Signs of allergy: Rash, swelling, itching, difficulty breathing.
  3. Seek emergency medical help if an allergic reaction occurs.

Storage Instructions
  1. Store at room temperature (15-30°C or 59-86°F).
  2. Keep in a dry place, away from moisture and direct sunlight.
  3. Keep out of reach of children.
  4. Do not use expired medication.

Overdose Information
Symptoms of overdose:
  1. Severe dizziness or fainting
  2. Irregular heartbeat
  3. Confusion or difficulty breathing
What to do in case of overdose?
  1. Seek emergency medical help immediately.
  2. Visit the nearest hospital or call a poison control center.

Missed Dose Instructions
  1. If you miss a dose, take it as soon as you remember.
  2. If it is almost time for the next dose, skip the missed dose—do not take a double dose.
  3. Never take extra tablets to make up for a missed dose.

Additional Notes:
  1. Regular medical check-ups are required to monitor liver function, potassium levels, and blood pressure.
  2. Do not stop taking Ahabir suddenly without medical advice.
  3. A healthy lifestyle, balanced diet, and exercise may help improve treatment outcomes.

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