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Enzamide 40mg - Enzalutamide Capsules

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Enzamide 40mg - Enzalutamide Capsules

Enzamide 40mg is an oral anti-cancer medication used primarily in the treatment of prostate cancer. It functions as an androgen receptor inhibitor, helping slow the growth and spread of cancer cells by blocking the effects of male hormones (androgens).

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Description Product Details
General Information:
Generic Name: Enzalutamide
Brand Name: Enzamide
Packing: Box containing strips of capsules (usually 28 or 112 capsules)
Strength: 40 mg per capsule
Manufacturer: Intas Pharmaceuticals Ltd.
Form: Oral capsule
Category: Anti-androgen, Hormonal therapy, Anti-cancer drug
Product Intro:
Enzamide 40mg is a prescription medicine used for the treatment of metastatic or non-metastatic castration-resistant prostate cancer (CRPC) and metastatic castration-sensitive prostate cancer (mCSPC). Manufactured by Intas Pharmaceuticals, it is part of a class of hormonal therapies designed to suppress cancer cell stimulation from androgens.
Uses:
  1. Metastatic Castration-Resistant Prostate Cancer (mCRPC)
  2. Non-metastatic Castration-Resistant Prostate Cancer (nmCRPC)
  3. Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
  4. Hormonal therapy in advanced prostate cancer
  5. Combination therapy with ADT (Androgen Deprivation Therapy)
  6. Relapse management in hormone-sensitive prostate cancer patients
Storage Instructions:
  1. Store at room temperature (20–25°C)
  2. Keep away from moisture and direct light
  3. Store in the original packaging
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Enzalutamide blocks the androgen receptor (AR) signaling pathway. Androgens like testosterone fuel the growth of prostate cancer cells. Enzamide inhibits:
  1. Binding of androgens to AR
  2. AR nuclear translocation
  3. AR-mediated DNA transcription
    This results in reduced cancer cell proliferation and tumor progression.
Side Effects:
Common Side Effects:
  1. Fatigue
  2. Back pain
  3. Hot flashes
  4. Hypertension
  5. Weakness
  6. Diarrhea
Severe Side Effects:
  1. Seizures (rare but serious)
  2. Falls and fractures
  3. Cognitive disorders (confusion, memory issues)
  4. Heart disorders (rare)
  5. Increased blood pressure
  6. Risk of posterior reversible encephalopathy syndrome (PRES) (very rare)
Dosage (Typical Recommended Dose):
  1. Standard dose: 160 mg once daily (usually 4 capsules of 40mg)
  2. Take at the same time each day
  3. Dose may be adjusted based on tolerance or organ function
  4. Administered with or without food
Method of Administration:
  1. Take capsules orally with a full glass of water
  2. Swallow whole; do not crush, chew, or open capsules
  3. Can be taken with or without meals
Precautions:
  1. Use with caution in patients with a history of seizures
  2. Regular monitoring of blood pressure is recommended
  3. Inform doctor about any neurological symptoms
  4. Not recommended during pregnancy or for women of childbearing potential
  5. Men should use contraception during treatment and for 3 months after
  6. Monitor liver function during treatment
Drug Interactions:
  1. Strong CYP3A4 inducers (e.g., rifampin) – reduce enzalutamide levels
  2. CYP2C8 and CYP3A4 substrates – may affect drug levels
  3. Warfarin and other anticoagulants – increased risk of bleeding
  4. Seizure-threshold lowering drugs – increase risk of seizures
  5. CNS-active drugs – monitor for enhanced CNS side effects
Allergies:
  1. Contraindicated in individuals with known hypersensitivity to Enzalutamide or ingredients in the capsule
  2. Symptoms may include:
    1. Skin rash
    2. Swelling of face/tongue
    3. Difficulty breathing
    4. Itching or redness
Overdose Information:
  1. Symptoms: Seizures, hypertension, fatigue, confusion
  2. Seek immediate medical attention
  3. Supportive treatment and close monitoring may be required in a medical facility
Missed Dose Instructions:
  1. Take the missed dose as soon as you remember on the same day
  2. If you miss an entire day, skip the missed dose and continue the next day
  3. Do not double up to make up for a missed dose
Additional Notes:
  1. Patients should be monitored regularly for blood pressure, liver enzymes, and signs of CNS effects
  2. Not to be used in female or pediatric patients
  3. Continue androgen deprivation therapy (ADT) during treatment
  4. Keep follow-up appointments for blood work and evaluation
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