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Wintaxel 120mg - Docetaxel Injection

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Wintaxel 120mg - Docetaxel Injection

Wintaxel 120mg is a Docetaxel Injection used in chemotherapy for breast cancer, lung cancer, prostate cancer, gastric cancer, and head & neck cancer. It works by stabilizing microtubules in cancer cells, preventing their division and leading to cell death.

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Description Product Details
General Information:
Generic Name: Docetaxel Injection
Brand Name: Wintaxel
Packing: Vial
Strength: 120 mg
Manufacturer: [Manufacturer Name]
Form: Intravenous Injection
Category: Chemotherapy / Antineoplastic Agent / Taxane Derivative
Product Introduction:
Wintaxel 120mg is a chemotherapy drug belonging to the taxane class. It contains Docetaxel, an anti-cancer agent that interferes with microtubule function, stopping cancer cells from multiplying. It is given as an intravenous (IV) infusion in a clinical setting under medical supervision.
Uses of Wintaxel 120mg Injection:
Wintaxel 120mg is indicated for the treatment of:
  1. Breast Cancer – Used as a single agent or with other chemotherapy drugs.
  2. Non-Small Cell Lung Cancer (NSCLC) – Given alone or in combination with platinum-based chemotherapy.
  3. Prostate Cancer – Used with Prednisone to treat hormone-refractory metastatic prostate cancer.
  4. Gastric (Stomach) Cancer – Administered as part of a combination therapy for advanced gastric cancer.
  5. Head & Neck Cancer – Used in advanced or recurrent squamous cell carcinoma.
  6. Ovarian Cancer (Off-label Use) – In some cases of platinum-resistant ovarian cancer.
Storage Instructions:
  1. Store at 2°C – 8°C (refrigerated temperature).
  2. Do not freeze or expose to high temperatures.
  3. Protect from light and store in its original packaging.
  4. Shake well before use if required.
  5. Dispose of unused medication as per hospital guidelines.
How Wintaxel 120mg Works (Mechanism of Action):
Docetaxel is a microtubule stabilizer that:
  1. Inhibits cell division – Binds to tubulin and stabilizes microtubules, preventing cancer cells from dividing.
  2. Induces apoptosis (programmed cell death) – Triggers cancer cell self-destruction.
  3. Prevents angiogenesis – Reduces blood supply to tumors, slowing their growth.
Side Effects:
Common Side Effects:
  1. Fatigue
  2. Nausea and vomiting
  3. Hair loss (alopecia)
  4. Low blood counts (neutropenia, anemia, thrombocytopenia)
  5. Loss of appetite
  6. Peripheral neuropathy (numbness, tingling)
  7. Skin rash, nail discoloration
Severe Side Effects (Rare but Serious):
  1. Severe allergic reactions – Swelling, breathing difficulty, rash
  2. Febrile neutropenia – Increased infection risk due to low white blood cells
  3. Liver toxicity – Jaundice, elevated liver enzymes
  4. Fluid retention syndrome – Swelling in limbs, lung congestion
  5. Severe neuropathy – Permanent nerve damage
Seek immediate medical help if severe side effects occur.
Dosage (Typical Recommended Dose):
Standard Chemotherapy Dosage (Varies by Cancer Type):
  1. Breast Cancer / Lung Cancer / Stomach Cancer / Head & Neck Cancer:
    1. 75–100 mg/m² IV infusion every 3 weeks, often with pre-medications.
  2. Prostate Cancer:
    1. 75 mg/m² IV infusion every 3 weeks + Prednisone.
  3. Reduced Dosages for High-Risk Patients:
    1. 60 mg/m² IV infusion for elderly or weak patients.
Dosage is based on body surface area (BSA), lab tests, and patient response.
Method of Administration:
  1. Administered as an intravenous (IV) infusion over 1 hour.
  2. Given in a hospital or clinic under oncologist supervision.
  3. Pre-medication with corticosteroids (e.g., Dexamethasone) is required to reduce allergic reactions and fluid retention.
  4. Blood tests and hydration are necessary before each chemotherapy cycle.
Precautions:
  1. Pre-medication (corticosteroids) reduces fluid retention and hypersensitivity reactions.
  2. Frequent blood tests are required to monitor white blood cell count and liver function.
  3. Avoid live vaccines while undergoing chemotherapy.
  4. Use contraception during and 6 months after treatment (for both men and women).
  5. Not recommended during pregnancy or breastfeeding.
  6. Patients with liver disease require dose adjustments and close monitoring.
Drug Interactions:
Wintaxel 120mg may interact with:
  1. CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) – Increases toxicity.
  2. CYP3A4 inducers (Rifampin, Carbamazepine, Phenytoin) – Reduces drug effectiveness.
  3. Blood Thinners (Warfarin, Aspirin) – Increases bleeding risk.
  4. Other Chemotherapy Drugs (Cisplatin, Doxorubicin, Capecitabine) – Requires dose adjustments.
  5. Live Vaccines – Higher risk of severe infections due to weakened immunity.
Inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
  1. Do not use if allergic to Docetaxel or its excipients.
  2. Symptoms of an allergic reaction include rash, swelling, difficulty breathing, dizziness.
  3. Pre-medication with corticosteroids is required to prevent severe reactions.
Overdose Information:
Symptoms of Overdose:
  1. Severe neutropenia (low white blood cells)
  2. Severe nausea, vomiting, and diarrhea
  3. Organ failure (kidney/liver damage)
  4. Breathing difficulty or severe allergic reaction
What to do in case of overdose?
  1. Seek immediate medical attention.
  2. Supportive care includes IV fluids, blood transfusion, and symptom management.
Missed Dose Instructions:
  1. If a dose is missed, the doctor will reschedule the next infusion.
  2. Do not self-administer or double the dose.
  3. Maintain regular follow-ups to avoid treatment delays.
Additional Notes:
  1. Stay hydrated to prevent kidney damage.
  2. Follow a neutropenic diet to minimize infection risk.
  3. Regular liver function tests are necessary.
  4. Hair loss is temporary and usually resolves after treatment.

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