Product Introduction:
Wintaxel 120mg is a chemotherapy drug belonging to the taxane class. It contains Docetaxel, an anti-cancer agent that interferes with microtubule function, stopping cancer cells from multiplying. It is given as an intravenous (IV) infusion in a clinical setting under medical supervision.
Uses of Wintaxel 120mg Injection:
Wintaxel 120mg is indicated for the treatment of:
-
Breast Cancer – Used as a single agent or with other chemotherapy drugs.
-
Non-Small Cell Lung Cancer (NSCLC) – Given alone or in combination with platinum-based chemotherapy.
-
Prostate Cancer – Used with Prednisone to treat hormone-refractory metastatic prostate cancer.
-
Gastric (Stomach) Cancer – Administered as part of a combination therapy for advanced gastric cancer.
-
Head & Neck Cancer – Used in advanced or recurrent squamous cell carcinoma.
-
Ovarian Cancer (Off-label Use) – In some cases of platinum-resistant ovarian cancer.
Storage Instructions:
-
Store at 2°C – 8°C (refrigerated temperature).
-
Do not freeze or expose to high temperatures.
-
Protect from light and store in its original packaging.
-
Shake well before use if required.
-
Dispose of unused medication as per hospital guidelines.
How Wintaxel 120mg Works (Mechanism of Action):
Docetaxel is a microtubule stabilizer that:
-
Inhibits cell division – Binds to tubulin and stabilizes microtubules, preventing cancer cells from dividing.
-
Induces apoptosis (programmed cell death) – Triggers cancer cell self-destruction.
-
Prevents angiogenesis – Reduces blood supply to tumors, slowing their growth.
Side Effects:
Common Side Effects:
-
Fatigue
-
Nausea and vomiting
-
Hair loss (alopecia)
-
Low blood counts (neutropenia, anemia, thrombocytopenia)
-
Loss of appetite
-
Peripheral neuropathy (numbness, tingling)
-
Skin rash, nail discoloration
Severe Side Effects (Rare but Serious):
-
Severe allergic reactions – Swelling, breathing difficulty, rash
-
Febrile neutropenia – Increased infection risk due to low white blood cells
-
Liver toxicity – Jaundice, elevated liver enzymes
-
Fluid retention syndrome – Swelling in limbs, lung congestion
-
Severe neuropathy – Permanent nerve damage
Seek immediate medical help if severe side effects occur.
Dosage (Typical Recommended Dose):
Standard Chemotherapy Dosage (Varies by Cancer Type):
-
Breast Cancer / Lung Cancer / Stomach Cancer / Head & Neck Cancer:
-
75–100 mg/m² IV infusion every 3 weeks, often with pre-medications.
-
Prostate Cancer:
-
75 mg/m² IV infusion every 3 weeks + Prednisone.
-
Reduced Dosages for High-Risk Patients:
-
60 mg/m² IV infusion for elderly or weak patients.
Dosage is based on body surface area (BSA), lab tests, and patient response.
Method of Administration:
-
Administered as an intravenous (IV) infusion over 1 hour.
-
Given in a hospital or clinic under oncologist supervision.
-
Pre-medication with corticosteroids (e.g., Dexamethasone) is required to reduce allergic reactions and fluid retention.
-
Blood tests and hydration are necessary before each chemotherapy cycle.
Precautions:
-
Pre-medication (corticosteroids) reduces fluid retention and hypersensitivity reactions.
-
Frequent blood tests are required to monitor white blood cell count and liver function.
-
Avoid live vaccines while undergoing chemotherapy.
-
Use contraception during and 6 months after treatment (for both men and women).
-
Not recommended during pregnancy or breastfeeding.
-
Patients with liver disease require dose adjustments and close monitoring.
Drug Interactions:
Wintaxel 120mg may interact with:
-
CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) – Increases toxicity.
-
CYP3A4 inducers (Rifampin, Carbamazepine, Phenytoin) – Reduces drug effectiveness.
-
Blood Thinners (Warfarin, Aspirin) – Increases bleeding risk.
-
Other Chemotherapy Drugs (Cisplatin, Doxorubicin, Capecitabine) – Requires dose adjustments.
-
Live Vaccines – Higher risk of severe infections due to weakened immunity.
Inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if allergic to Docetaxel or its excipients.
-
Symptoms of an allergic reaction include rash, swelling, difficulty breathing, dizziness.
-
Pre-medication with corticosteroids is required to prevent severe reactions.
Overdose Information:
Symptoms of Overdose:
-
Severe neutropenia (low white blood cells)
-
Severe nausea, vomiting, and diarrhea
-
Organ failure (kidney/liver damage)
-
Breathing difficulty or severe allergic reaction
What to do in case of overdose?
-
Seek immediate medical attention.
-
Supportive care includes IV fluids, blood transfusion, and symptom management.
Missed Dose Instructions:
-
If a dose is missed, the doctor will reschedule the next infusion.
-
Do not self-administer or double the dose.
-
Maintain regular follow-ups to avoid treatment delays.
Additional Notes:
-
Stay hydrated to prevent kidney damage.
-
Follow a neutropenic diet to minimize infection risk.
-
Regular liver function tests are necessary.
-
Hair loss is temporary and usually resolves after treatment.
Product Introduction:
Wintaxel 120mg is a chemotherapy drug belonging to the taxane class. It contains Docetaxel, an anti-cancer agent that interferes with microtubule function, stopping cancer cells from multiplying. It is given as an intravenous (IV) infusion in a clinical setting under medical supervision.
Uses of Wintaxel 120mg Injection:
Wintaxel 120mg is indicated for the treatment of:
-
Breast Cancer – Used as a single agent or with other chemotherapy drugs.
-
Non-Small Cell Lung Cancer (NSCLC) – Given alone or in combination with platinum-based chemotherapy.
-
Prostate Cancer – Used with Prednisone to treat hormone-refractory metastatic prostate cancer.
-
Gastric (Stomach) Cancer – Administered as part of a combination therapy for advanced gastric cancer.
-
Head & Neck Cancer – Used in advanced or recurrent squamous cell carcinoma.
-
Ovarian Cancer (Off-label Use) – In some cases of platinum-resistant ovarian cancer.
Storage Instructions:
-
Store at 2°C – 8°C (refrigerated temperature).
-
Do not freeze or expose to high temperatures.
-
Protect from light and store in its original packaging.
-
Shake well before use if required.
-
Dispose of unused medication as per hospital guidelines.
How Wintaxel 120mg Works (Mechanism of Action):
Docetaxel is a microtubule stabilizer that:
-
Inhibits cell division – Binds to tubulin and stabilizes microtubules, preventing cancer cells from dividing.
-
Induces apoptosis (programmed cell death) – Triggers cancer cell self-destruction.
-
Prevents angiogenesis – Reduces blood supply to tumors, slowing their growth.
Side Effects:
Common Side Effects:
-
Fatigue
-
Nausea and vomiting
-
Hair loss (alopecia)
-
Low blood counts (neutropenia, anemia, thrombocytopenia)
-
Loss of appetite
-
Peripheral neuropathy (numbness, tingling)
-
Skin rash, nail discoloration
Severe Side Effects (Rare but Serious):
-
Severe allergic reactions – Swelling, breathing difficulty, rash
-
Febrile neutropenia – Increased infection risk due to low white blood cells
-
Liver toxicity – Jaundice, elevated liver enzymes
-
Fluid retention syndrome – Swelling in limbs, lung congestion
-
Severe neuropathy – Permanent nerve damage
Seek immediate medical help if severe side effects occur.
Dosage (Typical Recommended Dose):
Standard Chemotherapy Dosage (Varies by Cancer Type):
-
Breast Cancer / Lung Cancer / Stomach Cancer / Head & Neck Cancer:
-
75–100 mg/m² IV infusion every 3 weeks, often with pre-medications.
-
Prostate Cancer:
-
75 mg/m² IV infusion every 3 weeks + Prednisone.
-
Reduced Dosages for High-Risk Patients:
-
60 mg/m² IV infusion for elderly or weak patients.
Dosage is based on body surface area (BSA), lab tests, and patient response.
Method of Administration:
-
Administered as an intravenous (IV) infusion over 1 hour.
-
Given in a hospital or clinic under oncologist supervision.
-
Pre-medication with corticosteroids (e.g., Dexamethasone) is required to reduce allergic reactions and fluid retention.
-
Blood tests and hydration are necessary before each chemotherapy cycle.
Precautions:
-
Pre-medication (corticosteroids) reduces fluid retention and hypersensitivity reactions.
-
Frequent blood tests are required to monitor white blood cell count and liver function.
-
Avoid live vaccines while undergoing chemotherapy.
-
Use contraception during and 6 months after treatment (for both men and women).
-
Not recommended during pregnancy or breastfeeding.
-
Patients with liver disease require dose adjustments and close monitoring.
Drug Interactions:
Wintaxel 120mg may interact with:
-
CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) – Increases toxicity.
-
CYP3A4 inducers (Rifampin, Carbamazepine, Phenytoin) – Reduces drug effectiveness.
-
Blood Thinners (Warfarin, Aspirin) – Increases bleeding risk.
-
Other Chemotherapy Drugs (Cisplatin, Doxorubicin, Capecitabine) – Requires dose adjustments.
-
Live Vaccines – Higher risk of severe infections due to weakened immunity.
Inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if allergic to Docetaxel or its excipients.
-
Symptoms of an allergic reaction include rash, swelling, difficulty breathing, dizziness.
-
Pre-medication with corticosteroids is required to prevent severe reactions.
Overdose Information:
Symptoms of Overdose:
-
Severe neutropenia (low white blood cells)
-
Severe nausea, vomiting, and diarrhea
-
Organ failure (kidney/liver damage)
-
Breathing difficulty or severe allergic reaction
What to do in case of overdose?
-
Seek immediate medical attention.
-
Supportive care includes IV fluids, blood transfusion, and symptom management.
Missed Dose Instructions:
-
If a dose is missed, the doctor will reschedule the next infusion.
-
Do not self-administer or double the dose.
-
Maintain regular follow-ups to avoid treatment delays.
Additional Notes:
-
Stay hydrated to prevent kidney damage.
-
Follow a neutropenic diet to minimize infection risk.
-
Regular liver function tests are necessary.
-
Hair loss is temporary and usually resolves after treatment.
