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Mamofen 20mg - Tamoxifen Citrate Tablet

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Mamofen 20mg - Tamoxifen Citrate Tablet

Mamofen 20mg contains Tamoxifen Citrate, a selective estrogen receptor modulator (SERM) used to treat and prevent breast cancer. It works by blocking estrogen receptors in breast tissue, thereby inhibiting cancer cell growth.

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Description Product Details
General Information:
Generic Name: Tamoxifen Citrate
Brand Name: Mamofen
Packing: Strip of 10 tablets
Strength: 20 mg
Manufacturer: Khandelwal Laboratories Pvt. Ltd.
Form: Oral tablet
Category: Antineoplastic (Hormonal therapy), SERM (Selective Estrogen Receptor Modulator)
Product Intro:
Mamofen 20mg is an oral anti-cancer medication primarily prescribed for hormone receptor-positive breast cancer. It is also used in patients at high risk to prevent the development of breast cancer. As a widely used hormonal therapy, Mamofen plays a key role in both early and advanced stages of breast cancer management.
Uses:
  1. Treatment of hormone receptor-positive breast cancer
  2. Prevention of breast cancer in high-risk women
  3. Adjuvant therapy after surgery or radiation in breast cancer
  4. Treatment of metastatic breast cancer
  5. Management of ductal carcinoma in situ (DCIS)
  6. Induction of ovulation in infertility (off-label use)
Storage Instructions:
  1. Store below 25°C, away from light and moisture
  2. Keep in original packaging
  3. Keep out of reach of children
How it Works (Mechanism of Action):
Tamoxifen is a Selective Estrogen Receptor Modulator (SERM). It binds to estrogen receptors in breast tissue and prevents estrogen from binding, which is essential for the growth of certain types of breast cancers. By blocking estrogen action, it slows or stops the growth of cancer cells that rely on estrogen.
Side Effects:
Common Side Effects:
  1. Hot flashes
  2. Vaginal discharge or dryness
  3. Nausea
  4. Fatigue
  5. Irregular menstruation
Severe Side Effects:
  1. Blood clots (DVT, pulmonary embolism)
  2. Endometrial or uterine cancer
  3. Stroke
  4. Vision problems (cataracts)
  5. Liver function disturbances
Dosage (Typical Recommended Dose):
  1. Standard dose is 20 mg once daily
  2. In some cases, 10 mg twice daily may be recommended
  3. Duration of therapy can range from 5 to 10 years based on clinical response and risk profile
Method of Administration:
  1. Should be taken by mouth with water
  2. Can be taken with or without food
  3. Take at the same time every day for best results
Precautions:
  1. Use cautiously in patients with a history of thrombosis
  2. Not recommended during pregnancy or breastfeeding
  3. Monitor for signs of uterine abnormalities
  4. Regular eye examinations may be necessary during long-term use
  5. Liver function and complete blood counts (CBC) should be monitored periodically
Drug Interactions:
  1. Avoid use with blood thinners (e.g., warfarin) unless advised
  2. May interact with SSRIs like fluoxetine or paroxetine (reduce tamoxifen effect)
  3. Caution with CYP2D6 inhibitors
Allergies:
  1. Contraindicated in individuals with known hypersensitivity to Tamoxifen or its components
  2. Signs of allergic reaction: rash, itching, swelling, dizziness, trouble breathing
Overdose Information:
  1. Overdose symptoms may include tremors, unsteady gait, or dizziness
  2. Seek immediate medical help
  3. Supportive care and symptom management are usually effective
Missed Dose Instructions:
  1. Take the missed dose as soon as remembered
  2. If it's close to the next dose, skip the missed one
  3. Do not take a double dose
Additional Notes:
  1. Effectiveness may take several weeks to observe
  2. Long-term use shown to significantly reduce recurrence and mortality in breast cancer
  3. Patients should be advised about possible fertility implications
  4. Regular pelvic exams may be recommended
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