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Geffy 250mg - Gefitinib Tablets

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Geffy 250mg - Gefitinib Tablets

Geffy 250mg is an anticancer medication used primarily in the treatment of non-small cell lung cancer (NSCLC). It works by targeting and inhibiting the epidermal growth factor receptor (EGFR) involved in cancer cell growth.

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Description Product Details
General Information:
Generic Name: Gefitinib
Brand Name: Geffy
Packing: Strip of tablets
Strength: 250 mg
Manufacturer: Intas Pharmaceuticals Ltd.
Form: Oral tablet
Category: Antineoplastic agent, EGFR tyrosine kinase inhibitor (TKI)
Product Intro:
Geffy 250mg, manufactured by Intas Pharmaceuticals, contains Gefitinib, a targeted therapy for treating EGFR mutation-positive non-small cell lung cancer. It is taken orally and provides a less invasive treatment alternative to traditional chemotherapy.
Uses:
  1. Non-small cell lung cancer (NSCLC) – especially with EGFR gene mutations
  2. Locally advanced or metastatic lung cancer
  3. First-line treatment in EGFR mutation-positive tumors
  4. Maintenance therapy post-chemotherapy response
  5. Alternative treatment in patients intolerant to traditional chemotherapy
  6. Off-label use in research for other EGFR-expressing tumors
Storage Instructions:
  1. Store at room temperature (15°C to 30°C)
  2. Keep in a dry place, away from direct sunlight and moisture
  3. Keep away from children and pets
  4. Do not use expired or damaged tablets
How it Works (Mechanism of Action):
Gefitinib is a selective inhibitor of EGFR tyrosine kinase, a protein involved in signaling pathways that control cell division and survival.
  1. It binds to the ATP-binding site of the EGFR
  2. Inhibits phosphorylation, blocking downstream signaling
  3. Reduces tumor cell proliferation, angiogenesis, and metastasis
It is particularly effective in cancers with specific EGFR gene mutations.
Side Effects:
Common Side Effects:
  1. Acne-like rash
  2. Diarrhea
  3. Nausea
  4. Loss of appetite
  5. Fatigue
  6. Dry skin
Severe Side Effects:
  1. Interstitial lung disease (rare but serious)
  2. Liver enzyme elevation
  3. Severe diarrhea or dehydration
  4. Eye disorders (e.g., keratitis)
  5. Gastrointestinal perforation (rare)
Dosage (Typical Recommended Dose):
  1. Standard dose: 250 mg once daily
  2. Taken continuously until disease progression or unacceptable toxicity
  3. No dose adjustment needed based on age or body weight
  4. Adjustments may be required in case of severe side effects
Method of Administration:
  1. Take orally with or without food
  2. Swallow the tablet whole with water
  3. If unable to swallow, it may be dispersed in water (no other liquids) and consumed immediately
  4. Take at the same time each day for best results
Precautions:
  1. Only for EGFR mutation-positive NSCLC patients
  2. Regular monitoring of liver function tests recommended
  3. Caution in patients with lung disease, liver disease, or gastrointestinal conditions
  4. Avoid pregnancy during and for at least 2 weeks after stopping treatment
  5. Not recommended during breastfeeding
Drug Interactions:
  1. CYP3A4 inducers (e.g., rifampicin, phenytoin) may reduce efficacy
  2. CYP3A4 inhibitors (e.g., ketoconazole) may increase toxicity
  3. Proton pump inhibitors and antacids can reduce absorption
  4. Warfarin – monitor INR closely
  5. Herbal supplements (e.g., St. John’s Wort) may interfere with its activity
Allergies:
  1. Do not use in patients with known hypersensitivity to Gefitinib or its excipients
  2. Watch for signs of allergic reactions:
    1. Skin rash, itching
    2. Swelling of face or tongue
    3. Difficulty breathing
Overdose Information:
  1. Symptoms of overdose may include:
    1. Severe diarrhea
    2. Rash
    3. Liver enzyme abnormalities
  2. There is no specific antidote; provide symptomatic and supportive care
  3. Seek immediate medical attention in case of overdose
Missed Dose Instructions:
  1. Take the missed dose as soon as remembered
  2. Skip the missed dose if it's almost time for the next one
  3. Do not take a double dose to make up for a missed one
Additional Notes:
  1. EGFR testing is recommended before initiating therapy
  2. Avoid sun exposure; use sunscreen and protective clothing
  3. Regular follow-up with oncologist is essential to monitor effectiveness and manage side effects
  4. Maintain hydration and oral care to reduce GI and skin issues
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