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Fuvestrol 250mg - Fulvestrant Injection

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Fuvestrol 250mg - Fulvestrant Injection

Fuvestrol 250mg is a potent hormonal therapy used for treating hormone receptor-positive metastatic breast cancer in postmenopausal women. It belongs to the SERD (Selective Estrogen Receptor Degrader) class and works by blocking estrogen receptors on cancer cells.

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Description Product Details
General Information:
Generic Name: Fulvestrant
Brand Name: Fuvestrol
Packing: Pre-filled syringe or vial
Strength: 250mg/5ml
Manufacturer: Celon Laboratories Ltd.
Form: Injection
Category: Oncology / Hormone Therapy / SERD
Product Intro:
Fuvestrol 250mg is an injectable form of Fulvestrant, indicated primarily for postmenopausal women with advanced or metastatic breast cancer that is hormone receptor-positive. It is often used when there is disease progression after other hormonal therapies. Administered intramuscularly, Fuvestrol helps reduce cancer cell growth by eliminating estrogen receptor function.
Uses:
Fuvestrol 250mg is used for the treatment of:
  1. Hormone receptor-positive metastatic breast cancer in postmenopausal women
  2. Breast cancer progression following anti-estrogen therapy
  3. HER2-negative breast cancer in combination with CDK4/6 inhibitors
  4. First-line therapy in advanced breast cancer
  5. Endocrine therapy failure
  6. Recurrent or relapsed hormone-sensitive breast cancer
Storage Instructions:
  1. Store at 2°C to 8°C (refrigerator)
  2. Do not freeze
  3. Protect from light
  4. Keep out of reach of children
  5. Allow to come to room temperature before injection
How it Works (Mechanism of Action):
Fuvestrol works as a Selective Estrogen Receptor Degrader (SERD). It binds competitively to estrogen receptors on cancer cells, blocks their activity, and accelerates their degradation. This process prevents estrogen from promoting cancer cell growth in hormone-dependent breast tumors.
Side Effects:
Common Side Effects:
  1. Injection site pain
  2. Nausea
  3. Hot flushes
  4. Fatigue
  5. Headache
  6. Joint and back pain
Serious Side Effects:
  1. Liver enzyme elevation
  2. Allergic reactions
  3. Blood clots (deep vein thrombosis or pulmonary embolism)
  4. Vaginal bleeding
  5. Bone pain
Dosage (Typical Recommended Dose):
  1. Initial dose: 500 mg on Day 1, Day 15, and Day 29
  2. Maintenance dose: 500 mg every 28 days
  3. Given as two 5ml injections, one in each gluteal muscle
Method of Administration:
  1. Administered intramuscularly (IM) in the buttock by a healthcare professional
  2. Alternate injection sites to avoid irritation
  3. Do not self-administer
Precautions:
  1. Not recommended in pregnant or breastfeeding women
  2. Use with caution in patients with hepatic impairment
  3. Use effective contraception during treatment and for 12 months after last dose
  4. Caution advised in patients with a history of thromboembolic disorders
Drug Interactions:
  1. Minimal known interactions, but caution with:
    1. Anticoagulants like warfarin
    2. Other estrogen-blocking drugs
  2. Inform your doctor of all medications and supplements
Allergies:
  1. Contraindicated in patients allergic to Fulvestrant or its components
  2. Signs of allergic reaction include:
    1. Swelling
    2. Rash
    3. Difficulty breathing
    4. Severe dizziness
  3. Seek emergency help if allergic symptoms occur
Overdose Information:
  1. Overdose is rare due to administration by medical personnel
  2. In case of suspected overdose: monitor for increased side effects (e.g., severe nausea, dizziness)
  3. Immediate medical intervention is necessary
Missed Dose Instructions:
  1. If a scheduled dose is missed, contact your healthcare provider
  2. Do not double the next dose
  3. Resume the schedule as directed by your physician
Additional Notes:
  1. Regular liver function tests and monitoring are recommended during treatment
  2. Fuvestrol may be combined with targeted therapies like Palbociclib for enhanced efficacy
  3. Not a curative treatment but effective in prolonging progression-free survival
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