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Naprodox 50mg - Doxorubicin Hydrochloride Injection

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Naprodox 50mg - Doxorubicin Hydrochloride Injection

Naprodox 50mg is a conventional Doxorubicin Hydrochloride injection, widely used in chemotherapy for various cancers including breast, bladder, lung, and blood cancers. It functions by interfering with DNA replication, thus halting the growth of cancer cells.

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Description Product Details
General Information:
Generic Name: Doxorubicin Hydrochloride
Brand Name: Naprodox
Packing: Single-use vial
Strength: 50mg
Manufacturer: [Manufacturer Name]
Form: Injection (IV use only)
Category: Antineoplastic / Anthracycline / Cytotoxic Antibiotic
Product Introduction:
Naprodox 50mg is an anthracycline-based chemotherapy injection containing Doxorubicin Hydrochloride. It is a cytotoxic antibiotic with a broad spectrum of activity against solid tumors and hematological malignancies. Administered intravenously, Naprodox must be handled with care due to its potent antineoplastic and cardiotoxic effects.
Uses of Naprodox 50mg Injection:
Naprodox is used to treat a wide range of cancers, including:
  1. Breast Cancer – Part of first-line or salvage regimens
  2. Bladder Cancer – Used in advanced or metastatic stages
  3. Lung Cancer (Small and Non-Small Cell) – In combination therapy
  4. Leukemia (Acute Lymphoblastic and Myeloid Leukemia)
  5. Lymphomas (Hodgkin's and Non-Hodgkin’s) – Commonly used in CHOP regimen
  6. Ovarian, Gastric, and Thyroid Cancers – In various combinations
Storage Instructions:
  1. Store at 2°C to 8°C (Refrigerated)
  2. Do not freeze
  3. Protect from light and heat
  4. Use immediately after reconstitution or as per guidelines
How Naprodox 50mg Works (Mechanism of Action):
Doxorubicin works by:
  1. Intercalating DNA strands, preventing DNA and RNA synthesis
  2. Inhibiting topoisomerase II, an enzyme necessary for DNA replication
  3. Generating free radicals, which damage cellular components and trigger apoptosis
    These actions collectively prevent the multiplication of cancer cells and cause their death.
Side Effects:
Common Side Effects:
  1. Nausea and vomiting
  2. Hair loss (Alopecia)
  3. Mucositis (mouth sores)
  4. Low white blood cell count (neutropenia)
  5. Fatigue
  6. Red urine (harmless discoloration)
Severe Side Effects:
  1. Cardiotoxicity (heart damage) – May lead to congestive heart failure
  2. Severe myelosuppression – Increases infection and bleeding risk
  3. Extravasation injury – Severe tissue damage if leaked outside vein
  4. Secondary leukemia (with prolonged use)
  5. Allergic reactions – Rash, itching, shortness of breath
Dosage (Typical Recommended Dose):
General Dosing:
  1. 60-75 mg/m² IV every 21 days, or
  2. 20-30 mg/m² on days 1 to 3 of a 21-day cycle, depending on the protocol and cancer type
The exact dose depends on body surface area (BSA), patient’s age, liver function, and response to therapy.
Method of Administration:
  1. IV infusion only, typically administered over 3 to 10 minutes
  2. Can be given via central venous catheter to reduce risk of extravasation
  3. Do not give intramuscularly or subcutaneously
  4. Use extreme caution during administration; extravasation causes necrosis
Precautions:
  1. Baseline cardiac evaluation (e.g., ECG, echocardiogram) required
  2. Monitor cumulative lifetime dose (limit: ~450–550 mg/m²) to reduce heart failure risk
  3. Use caution in patients with hepatic impairment – dosage adjustment may be necessary
  4. Avoid use during pregnancy and breastfeeding
  5. Use effective contraception during and after therapy (up to 6 months)
  6. Do not mix with heparin or alkaline solutions
Drug Interactions:
  1. Trastuzumab and Cyclophosphamide – Increase risk of cardiotoxicity
  2. Paclitaxel – Must be given before Doxorubicin to reduce toxicity
  3. Live vaccines – Increased risk of infection
  4. Calcium channel blockers – May mask signs of cardiotoxicity
  5. Other CYP450 substrates may influence Doxorubicin metabolism
Allergies (Warnings for Allergic Reactions):
  1. Contraindicated in patients with known hypersensitivity to Doxorubicin or related anthracyclines
  2. Symptoms of allergic reaction: rash, itching, swelling, difficulty breathing
  3. Emergency discontinuation and intervention are required in case of a reaction
Overdose Information:
Symptoms of Overdose:
  1. Severe myelosuppression
  2. Cardiac failure
  3. Mucositis, gastrointestinal bleeding
  4. Organ failure (liver, kidneys)
What to Do:
  1. Immediate hospitalization and supportive care
  2. Treat with G-CSF or GM-CSF for bone marrow support
  3. Cardiac monitoring and intervention if needed
Missed Dose Instructions:
  1. If a dose is missed, consult your oncologist immediately
  2. Do not self-adjust the dosing schedule
  3. Resume therapy based on medical evaluation
Additional Notes:
  1. Patients should be educated on early signs of infection or heart problems
  2. Avoid alcohol and hepatotoxic drugs during therapy
  3. Wigs, scarves, and gentle hair care may help during hair loss phase
  4. Regular CBC and LFTs are necessary
  5. Use protective gloves while handling the vial or bodily fluids of treated patients

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