Product Introduction:
Doceaqualip 80mg is a chemotherapy medication that belongs to the taxane class of anti-cancer drugs. It works by inhibiting microtubule function, leading to cancer cell death. This lipid-based formulation helps in reducing toxicity and side effects, making it a safer alternative for patients with solvent-based Docetaxel intolerance.
Uses of Doceaqualip 80mg Injection:
Doceaqualip 80mg is prescribed for the treatment of:
-
Breast Cancer – First-line or second-line therapy for advanced or metastatic breast cancer.
-
Non-Small Cell Lung Cancer (NSCLC) – Used alone or in combination with platinum-based chemotherapy.
-
Prostate Cancer – Treats hormone-refractory metastatic prostate cancer (often with prednisone).
-
Gastric (Stomach) Cancer – Used in combination therapy for advanced stomach cancer.
-
Head & Neck Cancer – Effective for locally advanced squamous cell carcinoma.
-
Ovarian Cancer (Off-label Use) – Used in platinum-resistant ovarian cancer cases.
Storage Instructions:
-
Store at 2°C – 8°C (refrigerated temperature).
-
Do not freeze or expose to extreme heat.
-
Keep in original packaging to protect from light.
-
Shake well before use if required.
-
Discard any unused portion as per hospital guidelines.
How Doceaqualip 80mg Works (Mechanism of Action):
Docetaxel is a microtubule inhibitor that:
-
Prevents cancer cell division – Stabilizes microtubules, stopping mitotic cell division.
-
Induces apoptosis (programmed cell death) – Triggers self-destruction of cancer cells.
-
Reduces angiogenesis – Prevents tumor blood vessel formation, slowing cancer growth.
The lipid-based suspension reduces hypersensitivity reactions and improves drug stability.
Side Effects:
Common Side Effects:
-
Fatigue and weakness
-
Nausea, vomiting, and diarrhea
-
Hair loss (alopecia)
-
Low blood counts (neutropenia, anemia, thrombocytopenia)
-
Loss of appetite
-
Peripheral neuropathy (numbness, tingling)
-
Skin rash, nail changes
Severe Side Effects (Rare but Serious):
-
Severe allergic reactions – Swelling, breathing difficulty, severe rash
-
Febrile neutropenia – Low white blood cells with fever, leading to infections
-
Liver toxicity – Jaundice, elevated liver enzymes
-
Fluid retention syndrome – Swelling in limbs, lung congestion
-
Severe neuropathy – Permanent nerve damage
Seek immediate medical attention if severe side effects occur.
Dosage (Typical Recommended Dose):
Chemotherapy Dosage (Varies by Cancer Type):
-
Breast Cancer / Lung Cancer / Stomach Cancer / Head & Neck Cancer:
-
75–100 mg/m² IV infusion every 3 weeks, often with pre-medications.
-
Prostate Cancer:
-
75 mg/m² IV infusion every 3 weeks + Prednisone.
-
Dose Adjustments:
-
60 mg/m² IV infusion for elderly or high-risk patients.
Dosage is adjusted based on body surface area (BSA), blood test results, and patient response.
Method of Administration:
-
Given as an intravenous (IV) infusion over 1 hour.
-
Administered in a hospital/clinic under oncologist supervision.
-
Pre-medication with corticosteroids (e.g., Dexamethasone) is recommended to reduce side effects.
-
Regular hydration and blood tests are required before and after treatment.
Precautions:
-
Pre-medications (corticosteroids) help reduce allergic reactions and fluid retention.
-
Frequent blood tests are needed to monitor white blood cell count and liver function.
-
Avoid live vaccines while undergoing treatment.
-
Use contraception during and 6 months after chemotherapy (for both men and women).
-
Not safe during pregnancy or breastfeeding.
-
Patients with liver disease require dose adjustments.
Drug Interactions:
Doceaqualip 80mg may interact with:
-
CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) – Increases toxicity risk.
-
CYP3A4 inducers (Rifampin, Carbamazepine, Phenytoin) – Lowers drug effectiveness.
-
Blood Thinners (Warfarin, Aspirin) – Increases bleeding risk.
-
Other Chemotherapy Drugs (Cisplatin, Doxorubicin, Capecitabine) – Requires careful dose adjustments.
-
Live Vaccines – Can lead to severe infections due to weakened immunity.
Inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if allergic to Docetaxel or lipid-based formulations.
-
Symptoms of an allergic reaction: rash, swelling, breathing difficulty, dizziness.
-
Pre-medication with corticosteroids is required to prevent severe hypersensitivity reactions.
Overdose Information:
Symptoms of Overdose:
-
Severe neutropenia (low white blood cells)
-
Severe nausea, vomiting, and diarrhea
-
Liver and kidney damage
-
Breathing difficulty or allergic reaction
What to do in case of overdose?
-
Seek emergency medical help immediately.
-
Supportive treatment includes IV fluids, blood transfusions, and symptom management.
Missed Dose Instructions:
-
If a dose is missed, contact your doctor immediately.
-
Do not self-administer or double the dose.
-
Follow-up treatment scheduling is important to maintain effectiveness.
Additional Notes:
-
Maintain proper hydration to prevent kidney complications.
-
Follow a neutropenic diet to avoid infections.
-
Liver function tests should be done regularly.
-
Hair loss is temporary and will reverse after treatment completion.
Product Introduction:
Doceaqualip 80mg is a chemotherapy medication that belongs to the taxane class of anti-cancer drugs. It works by inhibiting microtubule function, leading to cancer cell death. This lipid-based formulation helps in reducing toxicity and side effects, making it a safer alternative for patients with solvent-based Docetaxel intolerance.
Uses of Doceaqualip 80mg Injection:
Doceaqualip 80mg is prescribed for the treatment of:
-
Breast Cancer – First-line or second-line therapy for advanced or metastatic breast cancer.
-
Non-Small Cell Lung Cancer (NSCLC) – Used alone or in combination with platinum-based chemotherapy.
-
Prostate Cancer – Treats hormone-refractory metastatic prostate cancer (often with prednisone).
-
Gastric (Stomach) Cancer – Used in combination therapy for advanced stomach cancer.
-
Head & Neck Cancer – Effective for locally advanced squamous cell carcinoma.
-
Ovarian Cancer (Off-label Use) – Used in platinum-resistant ovarian cancer cases.
Storage Instructions:
-
Store at 2°C – 8°C (refrigerated temperature).
-
Do not freeze or expose to extreme heat.
-
Keep in original packaging to protect from light.
-
Shake well before use if required.
-
Discard any unused portion as per hospital guidelines.
How Doceaqualip 80mg Works (Mechanism of Action):
Docetaxel is a microtubule inhibitor that:
-
Prevents cancer cell division – Stabilizes microtubules, stopping mitotic cell division.
-
Induces apoptosis (programmed cell death) – Triggers self-destruction of cancer cells.
-
Reduces angiogenesis – Prevents tumor blood vessel formation, slowing cancer growth.
The lipid-based suspension reduces hypersensitivity reactions and improves drug stability.
Side Effects:
Common Side Effects:
-
Fatigue and weakness
-
Nausea, vomiting, and diarrhea
-
Hair loss (alopecia)
-
Low blood counts (neutropenia, anemia, thrombocytopenia)
-
Loss of appetite
-
Peripheral neuropathy (numbness, tingling)
-
Skin rash, nail changes
Severe Side Effects (Rare but Serious):
-
Severe allergic reactions – Swelling, breathing difficulty, severe rash
-
Febrile neutropenia – Low white blood cells with fever, leading to infections
-
Liver toxicity – Jaundice, elevated liver enzymes
-
Fluid retention syndrome – Swelling in limbs, lung congestion
-
Severe neuropathy – Permanent nerve damage
Seek immediate medical attention if severe side effects occur.
Dosage (Typical Recommended Dose):
Chemotherapy Dosage (Varies by Cancer Type):
-
Breast Cancer / Lung Cancer / Stomach Cancer / Head & Neck Cancer:
-
75–100 mg/m² IV infusion every 3 weeks, often with pre-medications.
-
Prostate Cancer:
-
75 mg/m² IV infusion every 3 weeks + Prednisone.
-
Dose Adjustments:
-
60 mg/m² IV infusion for elderly or high-risk patients.
Dosage is adjusted based on body surface area (BSA), blood test results, and patient response.
Method of Administration:
-
Given as an intravenous (IV) infusion over 1 hour.
-
Administered in a hospital/clinic under oncologist supervision.
-
Pre-medication with corticosteroids (e.g., Dexamethasone) is recommended to reduce side effects.
-
Regular hydration and blood tests are required before and after treatment.
Precautions:
-
Pre-medications (corticosteroids) help reduce allergic reactions and fluid retention.
-
Frequent blood tests are needed to monitor white blood cell count and liver function.
-
Avoid live vaccines while undergoing treatment.
-
Use contraception during and 6 months after chemotherapy (for both men and women).
-
Not safe during pregnancy or breastfeeding.
-
Patients with liver disease require dose adjustments.
Drug Interactions:
Doceaqualip 80mg may interact with:
-
CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) – Increases toxicity risk.
-
CYP3A4 inducers (Rifampin, Carbamazepine, Phenytoin) – Lowers drug effectiveness.
-
Blood Thinners (Warfarin, Aspirin) – Increases bleeding risk.
-
Other Chemotherapy Drugs (Cisplatin, Doxorubicin, Capecitabine) – Requires careful dose adjustments.
-
Live Vaccines – Can lead to severe infections due to weakened immunity.
Inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
-
Do not use if allergic to Docetaxel or lipid-based formulations.
-
Symptoms of an allergic reaction: rash, swelling, breathing difficulty, dizziness.
-
Pre-medication with corticosteroids is required to prevent severe hypersensitivity reactions.
Overdose Information:
Symptoms of Overdose:
-
Severe neutropenia (low white blood cells)
-
Severe nausea, vomiting, and diarrhea
-
Liver and kidney damage
-
Breathing difficulty or allergic reaction
What to do in case of overdose?
-
Seek emergency medical help immediately.
-
Supportive treatment includes IV fluids, blood transfusions, and symptom management.
Missed Dose Instructions:
-
If a dose is missed, contact your doctor immediately.
-
Do not self-administer or double the dose.
-
Follow-up treatment scheduling is important to maintain effectiveness.
Additional Notes:
-
Maintain proper hydration to prevent kidney complications.
-
Follow a neutropenic diet to avoid infections.
-
Liver function tests should be done regularly.
-
Hair loss is temporary and will reverse after treatment completion.
