Product Introduction:
Doceaqualip 80mg is a chemotherapy medication that belongs to the taxane class of anti-cancer drugs. It works by inhibiting microtubule function, leading to cancer cell death. This lipid-based formulation helps in reducing toxicity and side effects, making it a safer alternative for patients with solvent-based Docetaxel intolerance.
Uses of Doceaqualip 80mg Injection:
Doceaqualip 80mg is prescribed for the treatment of:
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Breast Cancer – First-line or second-line therapy for advanced or metastatic breast cancer.
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Non-Small Cell Lung Cancer (NSCLC) – Used alone or in combination with platinum-based chemotherapy.
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Prostate Cancer – Treats hormone-refractory metastatic prostate cancer (often with prednisone).
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Gastric (Stomach) Cancer – Used in combination therapy for advanced stomach cancer.
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Head & Neck Cancer – Effective for locally advanced squamous cell carcinoma.
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Ovarian Cancer (Off-label Use) – Used in platinum-resistant ovarian cancer cases.
Storage Instructions:
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Store at 2°C – 8°C (refrigerated temperature).
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Do not freeze or expose to extreme heat.
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Keep in original packaging to protect from light.
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Shake well before use if required.
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Discard any unused portion as per hospital guidelines.
How Doceaqualip 80mg Works (Mechanism of Action):
Docetaxel is a microtubule inhibitor that:
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Prevents cancer cell division – Stabilizes microtubules, stopping mitotic cell division.
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Induces apoptosis (programmed cell death) – Triggers self-destruction of cancer cells.
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Reduces angiogenesis – Prevents tumor blood vessel formation, slowing cancer growth.
The lipid-based suspension reduces hypersensitivity reactions and improves drug stability.
Side Effects:
Common Side Effects:
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Fatigue and weakness
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Nausea, vomiting, and diarrhea
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Hair loss (alopecia)
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Low blood counts (neutropenia, anemia, thrombocytopenia)
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Loss of appetite
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Peripheral neuropathy (numbness, tingling)
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Skin rash, nail changes
Severe Side Effects (Rare but Serious):
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Severe allergic reactions – Swelling, breathing difficulty, severe rash
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Febrile neutropenia – Low white blood cells with fever, leading to infections
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Liver toxicity – Jaundice, elevated liver enzymes
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Fluid retention syndrome – Swelling in limbs, lung congestion
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Severe neuropathy – Permanent nerve damage
Seek immediate medical attention if severe side effects occur.
Dosage (Typical Recommended Dose):
Chemotherapy Dosage (Varies by Cancer Type):
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Breast Cancer / Lung Cancer / Stomach Cancer / Head & Neck Cancer:
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75–100 mg/m² IV infusion every 3 weeks, often with pre-medications.
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Prostate Cancer:
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75 mg/m² IV infusion every 3 weeks + Prednisone.
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Dose Adjustments:
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60 mg/m² IV infusion for elderly or high-risk patients.
Dosage is adjusted based on body surface area (BSA), blood test results, and patient response.
Method of Administration:
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Given as an intravenous (IV) infusion over 1 hour.
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Administered in a hospital/clinic under oncologist supervision.
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Pre-medication with corticosteroids (e.g., Dexamethasone) is recommended to reduce side effects.
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Regular hydration and blood tests are required before and after treatment.
Precautions:
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Pre-medications (corticosteroids) help reduce allergic reactions and fluid retention.
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Frequent blood tests are needed to monitor white blood cell count and liver function.
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Avoid live vaccines while undergoing treatment.
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Use contraception during and 6 months after chemotherapy (for both men and women).
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Not safe during pregnancy or breastfeeding.
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Patients with liver disease require dose adjustments.
Drug Interactions:
Doceaqualip 80mg may interact with:
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CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) – Increases toxicity risk.
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CYP3A4 inducers (Rifampin, Carbamazepine, Phenytoin) – Lowers drug effectiveness.
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Blood Thinners (Warfarin, Aspirin) – Increases bleeding risk.
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Other Chemotherapy Drugs (Cisplatin, Doxorubicin, Capecitabine) – Requires careful dose adjustments.
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Live Vaccines – Can lead to severe infections due to weakened immunity.
Inform your doctor about all medications you are taking.
Allergies (Warnings for Allergic Reactions):
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Do not use if allergic to Docetaxel or lipid-based formulations.
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Symptoms of an allergic reaction: rash, swelling, breathing difficulty, dizziness.
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Pre-medication with corticosteroids is required to prevent severe hypersensitivity reactions.
Overdose Information:
Symptoms of Overdose:
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Severe neutropenia (low white blood cells)
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Severe nausea, vomiting, and diarrhea
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Liver and kidney damage
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Breathing difficulty or allergic reaction
What to do in case of overdose?
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Seek emergency medical help immediately.
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Supportive treatment includes IV fluids, blood transfusions, and symptom management.
Missed Dose Instructions:
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If a dose is missed, contact your doctor immediately.
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Do not self-administer or double the dose.
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Follow-up treatment scheduling is important to maintain effectiveness.
Additional Notes:
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Maintain proper hydration to prevent kidney complications.
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Follow a neutropenic diet to avoid infections.
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Liver function tests should be done regularly.
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Hair loss is temporary and will reverse after treatment completion.
