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Gefitero 250mg - Gefitinib Tablets

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Gefitero 250mg - Gefitinib Tablets

Gefitero 250mg is an EGFR tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer (NSCLC), particularly in patients with EGFR mutations. It targets cancer cells and prevents their growth and spread.

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Description Product Details
General Information:
Generic Name: Gefitinib
Brand Name: Gefitero
Packing: Strip of tablets
Strength: 250 mg
Manufacturer: Hetero Healthcare Ltd.
Form: Oral tablet
Category: Anticancer, EGFR Tyrosine Kinase Inhibitor (TKI)
Product Intro:
Gefitero 250mg, manufactured by Hetero Healthcare Ltd., contains Gefitinib, a targeted therapy for treating EGFR mutation-positive non-small cell lung cancer. This oral anticancer drug is suitable for first-line treatment and offers a personalized therapy option for lung cancer patients.
Uses:
  1. Non-small cell lung cancer (NSCLC) with EGFR mutations
  2. First-line treatment for advanced or metastatic NSCLC
  3. Maintenance therapy post-chemotherapy in EGFR-positive cases
  4. Second-line treatment after chemotherapy failure
  5. EGFR-overexpressing tumors (under research or off-label)
  6. Used in patients intolerant to standard chemotherapy
Storage Instructions:
  1. Store at room temperature (15–30°C)
  2. Keep away from heat, moisture, and direct sunlight
  3. Do not store in the bathroom
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Gefitinib is a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase.
  1. EGFR is often overexpressed or mutated in cancer cells
  2. Gefitinib binds to the ATP-binding site of EGFR
  3. It blocks signal transduction involved in cell proliferation, angiogenesis, and metastasis
  4. This leads to slowed tumor growth and reduced spread
Side Effects:
Common Side Effects:
  1. Rash or acne
  2. Diarrhea
  3. Dry skin
  4. Loss of appetite
  5. Nausea and vomiting
  6. Weakness and fatigue
Serious Side Effects:
  1. Interstitial lung disease (rare but serious)
  2. Liver toxicity
  3. Eye irritation or inflammation
  4. Severe diarrhea or dehydration
  5. Gastrointestinal bleeding or ulcers (rare)
Dosage (Typical Recommended Dose):
  1. Standard dose: 250 mg orally once daily
  2. Dose should not be increased above 250 mg
  3. Continue treatment as long as benefit is observed or until toxicity becomes unacceptable
  4. Dose modifications may be required in the case of adverse reactions
Method of Administration:
  1. Take the tablet once daily at the same time
  2. Swallow whole with water; do not crush, split, or chew
  3. Can be taken with or without food
  4. If unable to swallow, the tablet may be dispersed in water and consumed immediately
Precautions:
  1. Confirm EGFR mutation status before starting treatment
  2. Use caution in patients with pre-existing lung disease or impaired liver function
  3. Avoid pregnancy during and at least 2 weeks after stopping treatment
  4. Avoid breastfeeding while on Gefitinib
  5. Regular monitoring of liver enzymes and lung function is advised
Drug Interactions:
  1. CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase Gefitinib levels
  2. CYP3A4 inducers (e.g., rifampicin, phenytoin) may reduce its effectiveness
  3. Antacids and proton pump inhibitors can reduce absorption
  4. May interact with warfarin (increased risk of bleeding – monitor INR)
Allergies:
  1. Contraindicated in patients with known allergy to Gefitinib or its components
  2. Watch for signs of allergic reaction such as:
    1. Hives
    2. Swelling of face or lips
    3. Difficulty breathing
Overdose Information:
  1. Symptoms of overdose may include:
    1. Severe rash
    2. Diarrhea
    3. Nausea and vomiting
  2. No specific antidote exists
  3. Treatment is supportive and symptomatic
  4. Seek immediate medical help in case of overdose
Missed Dose Instructions:
  1. Take the missed dose as soon as remembered if it's on the same day
  2. If it’s almost time for the next dose, skip the missed one
  3. Do not take two doses at once to make up for a missed dose
Additional Notes:
  1. Perform genetic testing for EGFR mutations before initiating treatment
  2. Maintain good skin and oral hygiene to manage side effects
  3. Report any signs of lung issues (e.g., cough, shortness of breath) immediately
  4. Avoid using herbal supplements unless approved by your doctor
  5. Regular follow-up is necessary to assess treatment response and toxicity
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