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Veenat 100mg - Imatinib Tablet

Veenat 100mg is a targeted therapy medication used to treat various types of blood and gastrointestinal cancers. It contains Imatinib Mesylate, which works by stopping the growth of cancer cells.

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General Information:
Generic Name: Imatinib Mesylate
Brand Name: Veenat 100mg
Packing: Strip of 10 tablets
Strength: 100mg
Manufacturer: Natco Pharma Ltd.
Form: Tablet
Category: Anti-cancer, Tyrosine Kinase Inhibitor
Product Intro:
Veenat 100mg is a formulation of Imatinib, a tyrosine kinase inhibitor used in the treatment of specific cancers such as chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It is a reliable option for long-term management of these cancers, particularly when initiated early in the disease course.

Uses:
Veenat 100mg is used for the treatment of:
  1. Chronic Myeloid Leukemia (CML)
  2. Acute Lymphoblastic Leukemia (Ph+ ALL)
  3. Gastrointestinal Stromal Tumors (GIST)
  4. Hypereosinophilic Syndrome (HES)
  5. Myelodysplastic/Myeloproliferative Disorders (MDS/MPD)
  6. Dermatofibrosarcoma Protuberans (DFSP)

Storage Instructions:
  1. Store in a cool and dry place below 30°C
  2. Keep away from sunlight and moisture
  3. Keep out of reach of children
  4. Do not use after the expiry date

How it Works (Mechanism of Action):
Imatinib is a tyrosine kinase inhibitor that blocks the activity of abnormal proteins (like BCR-ABL) that signal cancer cells to multiply. By inhibiting these proteins, it prevents cancer cell growth and triggers programmed cell death.

Side Effects:
Common Side Effects:
  1. Nausea
  2. Vomiting
  3. Diarrhea
  4. Fatigue
  5. Rash
  6. Edema (swelling, especially around the eyes or limbs)
Severe Side Effects:
  1. Myelosuppression (low blood cell counts)
  2. Liver toxicity
  3. Severe fluid retention or pleural effusion
  4. Bleeding
  5. Severe allergic reactions (anaphylaxis, angioedema)

Dosage (Typical Recommended Dose):
  1. 100mg to 800mg daily depending on the type and stage of cancer
  2. For CML (chronic phase), usually 400mg daily
  3. For pediatric patients or certain adults, Veenat 100mg may be taken multiple times daily as prescribed

Method of Administration:
  1. Take orally with a full glass of water
  2. Preferably with food to minimize gastrointestinal upset
  3. Swallow whole, do not crush or chew

Precautions:
  1. Regular blood tests are required to monitor blood counts and liver function
  2. Use effective contraception during treatment
  3. Caution in patients with liver, kidney, or heart disease
  4. Avoid alcohol and grapefruit juice
  5. Not recommended during pregnancy or breastfeeding unless clearly needed

Drug Interactions:
  1. CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase toxicity
  2. CYP3A4 inducers (e.g., rifampin, phenytoin) may reduce efficacy
  3. Warfarin, acetaminophen, and NSAIDs may need dose adjustments or close monitoring

Allergies:
  1. Contraindicated in patients with known hypersensitivity to Imatinib
  2. Watch for symptoms such as rashes, itching, difficulty breathing, and swelling

Overdose Information:
  1. Symptoms may include nausea, vomiting, dizziness, and severe swelling
  2. Seek immediate medical attention or contact a poison control center

Missed Dose Instructions:
  1. Take the missed dose as soon as you remember
  2. If it's close to your next dose, skip the missed dose
  3. Do not double up on doses

Additional Notes:
  1. Maintain hydration and balanced nutrition
  2. Inform healthcare providers before surgery or starting new medication
  3. Long-term use may require dose adjustments based on response and tolerability
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