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Hertab 250mg - Lapatinib Tablet

Hertab 250mg is an oral anticancer medication containing Lapatinib, used primarily in the treatment of advanced or metastatic breast cancer. It works by blocking specific proteins that promote cancer cell growth.

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General Information:
Generic Name: Lapatinib
Brand Name: Hertab
Packing: Strip (commonly 10 tablets per strip)
Strength: 250 mg
Manufacturer: Hetero Healthcare Limited
Form: Oral Tablet
Category: Anticancer, Tyrosine Kinase Inhibitor (TKI)
Product Intro:
Hertab 250mg is a targeted therapy formulated with Lapatinib, a dual tyrosine kinase inhibitor. It is prescribed for patients with HER2-positive breast cancer, especially in combination with other therapies when previous treatments have not been effective. Manufactured to high-quality standards, it offers an effective oral alternative in cancer management.

Uses:
  1. HER2-positive metastatic breast cancer (in combination with capecitabine)
  2. Advanced breast cancer in patients who have received prior therapy
  3. HER2-positive breast cancer with hormone receptor-positive status (with letrozole)
  4. For use when trastuzumab therapy has failed
  5. Brain metastases prevention (in some advanced cases)
  6. Investigated for gastric cancer and other solid tumors (off-label uses under research)

Storage Instructions:
  1. Store at room temperature, 15°C to 30°C
  2. Keep in original packaging, away from light and moisture
  3. Keep out of reach of children

How it Works (Mechanism of Action):
Lapatinib is a dual tyrosine kinase inhibitor that blocks the HER2 (ErbB2) and EGFR (ErbB1) receptors on cancer cells.
  1. By inhibiting these pathways, it prevents cancer cell proliferation and survival
  2. It interferes with the signal transduction involved in the growth of tumor cells

Side Effects:
Common Side Effects:
  1. Diarrhea
  2. Rash or dry skin
  3. Nausea, vomiting
  4. Fatigue
  5. Hand-foot syndrome (in combination therapy)
  6. Loss of appetite
Serious Side Effects:
  1. Liver toxicity (increased liver enzymes)
  2. Heart issues (left ventricular dysfunction)
  3. Severe skin reactions
  4. QT prolongation (irregular heartbeat)
  5. Interstitial lung disease (rare)

Dosage (Typical Recommended Dose):
  1. Standard dose: 1,250 mg once daily (i.e., five 250 mg tablets)
  2. Taken on an empty stomach, at least 1 hour before or 1 hour after food
  3. Dosage varies based on combination regimen and patient condition
  4. Follow doctor’s instructions strictly

Method of Administration:
  1. Oral use only
  2. Swallow tablets whole with a full glass of water
  3. Take at the same time daily
  4. Do not crush, split, or chew

Precautions:
  1. Regular monitoring of liver function and cardiac health
  2. Not recommended during pregnancy or breastfeeding
  3. Use effective contraception during and at least 1 week after therapy
  4. Use with caution in patients with cardiac disease or liver disorders

Drug Interactions:
  1. Avoid with strong CYP3A4 inhibitors or inducers (e.g., ketoconazole, rifampin)
  2. Interacts with digoxin, warfarin, and certain antifungals or antibiotics
  3. Grapefruit juice may increase drug levels – avoid during treatment
  4. Co-administer with capecitabine or letrozole must be medically supervised

Allergies:
  1. Not to be used in patients with known hypersensitivity to Lapatinib
  2. Watch for signs of allergic reaction such as rash, hives, or breathing difficulty

Overdose Information:
  1. Symptoms may include severe diarrhea, nausea, heart issues
  2. In case of overdose, seek emergency medical care
  3. No specific antidote; treatment is symptomatic and supportive

Missed Dose Instructions:
  1. Take the missed dose as soon as remembered within 12 hours
  2. If more than 12 hours have passed, skip the missed dose
  3. Do not double up to make up for the missed dose

Additional Notes:
  1. Ensure regular monitoring of liver and heart function during treatment
  2. Inform your healthcare provider of all medicines and supplements you are using
  3. Maintain hydration and follow a nutritious diet
  4. Therapy effectiveness may take weeks to assess
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