Product Introduction:
Bryxta 400mg Injection is an anti-cancer medication used for the treatment of different types of cancers by preventing the growth of blood vessels that supply nutrients to tumors. It is typically used in combination with chemotherapy and administered intravenously (IV) under medical supervision.
Uses of Bryxta 400mg
Bryxta 400mg is prescribed for the treatment of:
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Metastatic Colorectal Cancer (mCRC) – Used with chemotherapy.
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Non-Small Cell Lung Cancer (NSCLC) – Advanced or metastatic cases.
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Ovarian and Cervical Cancer – Often combined with chemotherapy.
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Renal Cell Carcinoma (Kidney Cancer) – Advanced-stage treatment.
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Glioblastoma (Brain Cancer) – For recurrent tumors.
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Other Solid Tumors (Off-label Use) – As recommended by an oncologist.
How Bryxta 400mg Works (Mechanism of Action):
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Bevacizumab binds to VEGF, blocking its interaction with VEGF receptors on endothelial cells.
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VEGF is crucial for angiogenesis (formation of new blood vessels), which helps tumors grow.
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By inhibiting VEGF, Bryxta prevents blood vessel formation, starving the tumor of oxygen and nutrients, thereby slowing its growth.
Dosage of Bryxta 400mg
Typical Recommended Dose:
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Metastatic Colorectal Cancer (mCRC):
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Non-Small Cell Lung Cancer (NSCLC):
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Renal Cell Carcinoma (Kidney Cancer):
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Glioblastoma (Brain Cancer):
📌 Dosage may vary based on the patient’s weight and medical condition.
Method of Administration (How to Take It)
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Administered via intravenous (IV) infusion in a hospital or clinical setting.
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First infusion: Given over 90 minutes; subsequent doses may be reduced to 30-60 minutes if well tolerated.
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Not for self-administration – must be given under medical supervision.
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Premedication (anti-nausea drugs) may be required to prevent side effects.
Side Effects of Bryxta 400mg
Common Side Effects:
Severe Side Effects (Seek Immediate Medical Help):
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Severe bleeding – Coughing up blood, black stools.
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Gastrointestinal perforation – Severe stomach pain, bloating.
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Delayed wound healing – Avoid use before/after surgery.
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Blood clot formation – Stroke symptoms, swelling in legs.
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Kidney problems – Protein in urine, swelling in feet.
⚠️ Regular monitoring of blood pressure, kidney function, and wound healing is required.
Precautions Before Taking Bryxta 400mg
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Pregnant & Breastfeeding Women: Avoid use due to potential harm to the baby.
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Surgery Patients: Stop Bryxta at least 28 days before & after surgery to prevent wound healing issues.
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Heart Disease or Stroke Patients: Higher risk of blood clots.
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High Blood Pressure Patients: Regular BP monitoring required.
Drug Interactions (Medications That May Interact)
Bryxta 400mg may interact with:
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Blood Thinners (Warfarin, Aspirin, Heparin): Increased bleeding risk.
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NSAIDs (Ibuprofen, Naproxen): May worsen kidney damage.
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Other Cancer Therapies: Adjustments may be required.
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Immunosuppressants (Corticosteroids, Cyclosporine): May alter immune response.
⚠️ Always inform your doctor about all medications and supplements you take.
Allergy Warnings
🚨 Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
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Store in a refrigerator at 2°C - 8°C.
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Do not freeze or shake the vial.
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Keep in original packaging, away from light.
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Use within the prescribed period after dilution.
Overdose Information
Symptoms of Overdose:
What to Do in Case of Overdose?
Missed Dose Instructions
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Contact your doctor immediately if a dose is missed.
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Do not self-administer a missed dose.
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Do not double up on doses.
