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Venclexta 100mg - Venetoclax Film Coated Tablets

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Venclexta 100mg - Venetoclax Film Coated Tablets

Venclexta 100mg is a targeted oral cancer therapy used in the treatment of certain blood cancers, particularly chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). It works by blocking a protein that helps cancer cells survive.

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Description Product Details
General Information:
Generic Name: Venetoclax
Brand Name: Venclexta
Packing: 28 film-coated tablets
Strength: 100 mg per tablet
Company: AbbVie Healthcare India Private Limited
Manufacturer: AbbVie Inc.
Form: Film-coated oral tablet
Category: Anticancer drug / BCL-2 inhibitor
Product Intro:
Venclexta 100mg, manufactured by AbbVie, is an oral BCL-2 inhibitor used in hematologic malignancies. It is part of precision oncology treatment plans and is often used alone or in combination with other chemotherapy agents for better efficacy.
Uses:
  1. Chronic Lymphocytic Leukemia (CLL) – with or without 17p deletion
  2. Small Lymphocytic Lymphoma (SLL)
  3. Acute Myeloid Leukemia (AML) – especially in older adults or those unfit for intensive chemotherapy
  4. Combination therapy with obinutuzumab or azacitidine/decitabine
  5. Relapsed or refractory blood cancers
  6. Investigational uses in other BCL-2-expressing cancers under clinical trials
Storage Instructions:
  1. Store at room temperature (20°C to 25°C)
  2. Keep away from moisture, light, and heat
  3. Keep in original container with the lid tightly closed
  4. Do not use if tablets appear damaged or discolored
How it Works (Mechanism of Action):
Venetoclax selectively inhibits BCL-2, a protein that prevents apoptosis (programmed cell death). Many blood cancers rely on BCL-2 to evade death. By blocking BCL-2, Venclexta promotes the natural death of cancer cells, particularly in CLL and AML.
Side Effects:
Common Side Effects:
  1. Nausea
  2. Diarrhea
  3. Fatigue
  4. Low white blood cell count (neutropenia)
  5. Anemia
  6. Headache
Severe Side Effects:
  1. Tumor Lysis Syndrome (TLS) – life-threatening complication due to rapid cancer cell breakdown
  2. Severe neutropenia or febrile neutropenia
  3. Infections – pneumonia, sepsis
  4. Hepatotoxicity – liver enzyme elevation
  5. Severe gastrointestinal symptoms
Dosage (Typical Recommended Dose):
  1. Starting dose: 20 mg once daily, gradually increased over 5 weeks to reduce TLS risk
  2. Target dose: 400 mg once daily (depending on regimen)
  3. Dose may vary in combination therapy or for renal/hepatic impairment
  4. Always follow your doctor's titration schedule strictly
Method of Administration:
  1. Take orally with food, preferably at the same time each day
  2. Swallow tablets whole with water; do not crush or chew
  3. Must be administered as part of a dose ramp-up schedule under medical supervision
Precautions:
  1. Risk of Tumor Lysis Syndrome – requires pre-treatment hydration and uric acid-lowering agents
  2. Frequent blood tests are needed during ramp-up phase
  3. Use with caution in renal or hepatic impairment
  4. Avoid grapefruit and Seville oranges (can increase drug levels)
  5. Effective contraception is advised during and post-treatment for both men and women
  6. Not recommended during pregnancy or breastfeeding
Drug Interactions:
  1. CYP3A inhibitors (e.g., ketoconazole, ritonavir) – may increase venetoclax toxicity
  2. CYP3A inducers (e.g., rifampin) – may reduce effectiveness
  3. P-gp and BCRP inhibitors – can increase exposure
  4. Antifungals (like posaconazole) – may need dose adjustment
  5. Warfarin and other anticoagulants – monitor closely
Allergies:
  1. Avoid in patients with known hypersensitivity to venetoclax or any tablet ingredients
  2. Monitor for signs of allergic reaction, including:
    1. Rash
    2. Swelling of face/lips
    3. Breathing difficulty
    4. Itching or hives
Overdose Information:
  1. Symptoms: Severe neutropenia, increased infection risk, gastrointestinal symptoms
  2. Seek emergency medical care
  3. Hospitalization may be required for symptom management and monitoring
Missed Dose Instructions:
  1. Take the missed dose as soon as remembered on the same day
  2. If missed by more than 8 hours, skip the missed dose and resume normal schedule
  3. Do not double the dose to make up for a missed one
  4. If more than 2 consecutive doses are missed, contact your doctor before restarting
Additional Notes:
  1. TLS is a serious risk—never self-adjust doses
  2. Always take exactly as prescribed with close medical supervision
  3. Carry a list of all medications and supplements to avoid harmful interactions
  4. Periodic CBC, kidney, and liver function tests are critical
  5. Inform your doctor of any signs of infection, weakness, or unusual bleeding
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