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Emgrast 300mcg - Filgrastim Injection

Emgrast 300mcg is a recombinant human granulocyte colony-stimulating factor (G-CSF) injection used to boost white blood cell (WBC) production in patients undergoing chemotherapy, bone marrow transplantation, or suffering from neutropenia. It helps reduce the risk of infections by accelerating neutrophil recovery.

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Description Product Details

General Information:

Generic Name: Filgrastim

Brand Name: Emgrast

Packing: Pre-filled syringe or vial

Strength: 300 mcg (0.3 mg) per 1 ml

Manufacturer: Emcure Pharmaceuticals Ltd.

Form: Injection

Category: Hematopoietic Agent / G-CSF

Product Intro:

Emgrast 300mcg is a sterile, clear solution for subcutaneous or intravenous injection that contains Filgrastim. Developed by Emcure Pharmaceuticals, it is used widely in oncology and hematology to manage neutropenia and improve patient outcomes during aggressive cancer treatments.

Uses:

Emgrast 300mcg is indicated for:

Neutropenia due to chemotherapy
Neutropenia following bone marrow transplantation
Chronic neutropenia (congenital, cyclic, idiopathic)
HIV-associated neutropenia
Mobilization of hematopoietic progenitor cells prior to stem cell collection
Radiation-induced bone marrow suppression

Storage Instructions:

Store in a refrigerator at 2°C to 8°C
Do not freeze
Protect from light and heat
Keep the vial/syringe in the original carton until use
Allow to reach room temperature before injection

How it Works (Mechanism of Action):

Filgrastim is a colony-stimulating factor that stimulates the bone marrow to produce neutrophils, a type of white blood cell that helps the body fight infections. It binds to specific cell surface receptors to trigger proliferation, differentiation, and activation of neutrophils.

Side Effects:

Common Side Effects:

Bone pain
Fever
Headache
Muscle aches
Fatigue
Injection site redness or pain

Severe Side Effects:

Spleen enlargement or rupture
Acute respiratory distress syndrome (ARDS)
Serious allergic reactions
Capillary leak syndrome
Thrombocytopenia (low platelet count)

Dosage (Typical Recommended Dose):

Chemotherapy-induced neutropenia: 5 mcg/kg/day
Stem cell mobilization: 10 mcg/kg/day
Dosage may vary based on body weight and condition; physician discretion required

Method of Administration:

Can be administered subcutaneously (SC) or intravenously (IV)
Should be given once daily until neutrophil count returns to normal
Administered by a healthcare provider or trained caregiver/patient (for SC use)

Precautions:

Use with caution in patients with sickle cell disease or myeloid malignancies
Monitor for signs of splenic rupture
Regular blood count monitoring is essential
Not for use to increase chemotherapy dose intensity
Evaluate risks in pregnant or breastfeeding women

Drug Interactions:

No significant drug interactions reported
Avoid concurrent use with lithium unless prescribed, as it may enhance the effect of Filgrastim
Always inform your doctor about all current medications

Allergies:

Contraindicated in individuals with known hypersensitivity to Filgrastim or E. coli-derived proteins
Watch for symptoms like rash, swelling, difficulty breathing

Overdose Information:

Overdose may result in excessive leukocytosis or bone pain
Treatment includes symptomatic support and dose adjustment

Missed Dose Instructions:

If a dose is missed, take it as soon as remembered
Skip the missed dose if it's almost time for the next one
Do not double dose to make up for the missed injection

Additional Notes:

Blood tests are necessary to monitor white blood cell levels
Filgrastim is not a chemotherapy drug, but used alongside it
Inform your doctor about any unusual symptoms immediately