Product Introduction:
Samtica 500 mg is a hormonal therapy drug primarily used to treat advanced-stage prostate cancer that has spread beyond the prostate gland.
It is prescribed in:
-
Metastatic Castration-Resistant Prostate Cancer (mCRPC) – When the disease continues to progress despite hormonal therapy or surgical castration.
-
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – Used early in advanced cases to improve survival and slow disease progression.
Since prostate cancer cells need androgens (male hormones) like testosterone to grow, Samtica 500 mg works by reducing androgen production, helping slow down cancer spread. Prednisone is always prescribed alongside Samtica to prevent potential hormone-related side effects.
Uses of Samtica 500 mg
Samtica is primarily used for prostate cancer treatment in the following conditions:
-
Metastatic Castration-Resistant Prostate Cancer (mCRPC) – When cancer continues to grow despite standard hormonal therapy.
-
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – Helps improve overall survival in newly diagnosed advanced cases.
-
Delaying Chemotherapy – Helps patients avoid or postpone chemotherapy.
-
Post-Surgical Treatment – Used to lower the risk of cancer recurrence after surgery.
-
Prostate Cancer Symptom Relief – Helps reduce pain and discomfort caused by tumor growth.
How Samtica 500 mg Works (Mechanism of Action):
Samtica (Abiraterone Acetate) is a CYP17 enzyme inhibitor that blocks testosterone production, which is crucial for prostate cancer cell survival.
-
Inhibits the CYP17 enzyme, a key enzyme in testosterone synthesis.
-
Stops the production of androgens (testosterone and related hormones) from the adrenal glands, testes, and tumor cells.
-
Lowers overall androgen levels, reducing tumor growth and slowing disease progression.
Because testosterone reduction can disrupt hormone balance, prednisone is always prescribed alongside Samtica to prevent complications such as high blood pressure and fluid retention.
Dosage of Samtica 500 mg
Recommended Dosage:
-
Standard Dose: 1000 mg per day (Two 500 mg tablets once daily)
-
Taken with prednisone: 5 mg twice daily
-
Doctor may adjust the dose based on patient response and side effects.
Dosage Adjustments for Liver Issues:
-
Patients with liver problems may need a lower dose.
-
Regular liver function tests are required to monitor for potential liver toxicity.
Method of Administration (How to Take It)
-
Take Samtica on an empty stomach, at least 1 hour before or 2 hours after eating.
-
Swallow the tablet whole with a full glass of water.
-
Do not chew, crush, or break the tablet before swallowing.
-
Take the medication at the same time each day for the best results.
-
Prednisone is required to reduce the risk of hormonal imbalances and side effects.
Side Effects of Samtica 500 mg
Common Side Effects:
-
Fatigue & Weakness
-
High blood pressure (Hypertension)
-
Swelling in legs or feet (Fluid retention/Edema)
-
Low potassium levels (Hypokalemia)
-
Hot flashes
-
Increased liver enzyme levels
-
Joint pain (Arthralgia)
Severe Side Effects:
-
Heart problems (Arrhythmias, Heart failure, Chest pain)
-
Severe liver damage (Hepatotoxicity, Jaundice)
-
Adrenal insufficiency (Hormonal imbalance causing dizziness, weakness, low blood pressure)
-
Severe allergic reactions (Rash, swelling, difficulty breathing)
⚠️ Seek immediate medical attention if you experience chest pain, severe dizziness, yellowing of the skin (jaundice), or difficulty breathing.
Precautions Before Taking Samtica 500 mg
-
Not for use in women or children – Can cause severe harm if taken by pregnant women.
-
Regular blood tests are necessary to monitor liver function, blood pressure, and potassium levels.
-
Patients with heart disease should use caution – Risk of heart-related side effects.
-
Avoid grapefruit or grapefruit juice – Can increase the risk of side effects.
-
Use effective contraception – Male patients should take precautions to prevent pregnancy in their partners.
Drug Interactions (Medications That May Interact)
Samtica 500 mg can interact with several medications, including:
Avoid using with:
-
Strong CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce effectiveness.
-
CYP2D6 substrates (e.g., Metoprolol, Codeine) – Can alter drug levels.
-
Blood thinners (Warfarin, Heparin) – May increase the risk of bleeding.
-
Corticosteroids (other than prednisone) – Can disrupt hormone levels.
-
Heart medications (Digoxin, Amiodarone) – Can cause heart complications.
Allergy Warnings
-
Do not use if allergic to Abiraterone Acetate or any ingredients in Samtica.
-
Signs of allergy: Rash, swelling, severe itching, difficulty breathing.
-
Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
-
Store at room temperature (15-30°C or 59-86°F).
-
Keep in a dry place, away from moisture and direct sunlight.
-
Keep out of reach of children.
-
Do not use expired medication.
Overdose Information
Symptoms of overdose:
-
Severe dizziness or fainting
-
Irregular heartbeat
-
Confusion or difficulty breathing
What to do in case of overdose?
-
Seek emergency medical help immediately.
-
Visit the nearest hospital or call a poison control center.
Missed Dose Instructions
-
If you miss a dose, take it as soon as you remember.
-
If it is almost time for the next dose, skip the missed dose—do not take a double dose.
-
Never take extra tablets to make up for a missed dose.
Additional Notes:
-
Regular monitoring is required for liver function, blood pressure, and potassium levels.
-
Do not stop taking the medication suddenly without a doctor’s guidance.
-
A healthy diet and exercise may improve treatment outcomes.
Product Introduction:
Samtica 500 mg is a hormonal therapy drug primarily used to treat advanced-stage prostate cancer that has spread beyond the prostate gland.
It is prescribed in:
-
Metastatic Castration-Resistant Prostate Cancer (mCRPC) – When the disease continues to progress despite hormonal therapy or surgical castration.
-
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – Used early in advanced cases to improve survival and slow disease progression.
Since prostate cancer cells need androgens (male hormones) like testosterone to grow, Samtica 500 mg works by reducing androgen production, helping slow down cancer spread. Prednisone is always prescribed alongside Samtica to prevent potential hormone-related side effects.
Uses of Samtica 500 mg
Samtica is primarily used for prostate cancer treatment in the following conditions:
-
Metastatic Castration-Resistant Prostate Cancer (mCRPC) – When cancer continues to grow despite standard hormonal therapy.
-
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – Helps improve overall survival in newly diagnosed advanced cases.
-
Delaying Chemotherapy – Helps patients avoid or postpone chemotherapy.
-
Post-Surgical Treatment – Used to lower the risk of cancer recurrence after surgery.
-
Prostate Cancer Symptom Relief – Helps reduce pain and discomfort caused by tumor growth.
How Samtica 500 mg Works (Mechanism of Action):
Samtica (Abiraterone Acetate) is a CYP17 enzyme inhibitor that blocks testosterone production, which is crucial for prostate cancer cell survival.
-
Inhibits the CYP17 enzyme, a key enzyme in testosterone synthesis.
-
Stops the production of androgens (testosterone and related hormones) from the adrenal glands, testes, and tumor cells.
-
Lowers overall androgen levels, reducing tumor growth and slowing disease progression.
Because testosterone reduction can disrupt hormone balance, prednisone is always prescribed alongside Samtica to prevent complications such as high blood pressure and fluid retention.
Dosage of Samtica 500 mg
Recommended Dosage:
-
Standard Dose: 1000 mg per day (Two 500 mg tablets once daily)
-
Taken with prednisone: 5 mg twice daily
-
Doctor may adjust the dose based on patient response and side effects.
Dosage Adjustments for Liver Issues:
-
Patients with liver problems may need a lower dose.
-
Regular liver function tests are required to monitor for potential liver toxicity.
Method of Administration (How to Take It)
-
Take Samtica on an empty stomach, at least 1 hour before or 2 hours after eating.
-
Swallow the tablet whole with a full glass of water.
-
Do not chew, crush, or break the tablet before swallowing.
-
Take the medication at the same time each day for the best results.
-
Prednisone is required to reduce the risk of hormonal imbalances and side effects.
Side Effects of Samtica 500 mg
Common Side Effects:
-
Fatigue & Weakness
-
High blood pressure (Hypertension)
-
Swelling in legs or feet (Fluid retention/Edema)
-
Low potassium levels (Hypokalemia)
-
Hot flashes
-
Increased liver enzyme levels
-
Joint pain (Arthralgia)
Severe Side Effects:
-
Heart problems (Arrhythmias, Heart failure, Chest pain)
-
Severe liver damage (Hepatotoxicity, Jaundice)
-
Adrenal insufficiency (Hormonal imbalance causing dizziness, weakness, low blood pressure)
-
Severe allergic reactions (Rash, swelling, difficulty breathing)
⚠️ Seek immediate medical attention if you experience chest pain, severe dizziness, yellowing of the skin (jaundice), or difficulty breathing.
Precautions Before Taking Samtica 500 mg
-
Not for use in women or children – Can cause severe harm if taken by pregnant women.
-
Regular blood tests are necessary to monitor liver function, blood pressure, and potassium levels.
-
Patients with heart disease should use caution – Risk of heart-related side effects.
-
Avoid grapefruit or grapefruit juice – Can increase the risk of side effects.
-
Use effective contraception – Male patients should take precautions to prevent pregnancy in their partners.
Drug Interactions (Medications That May Interact)
Samtica 500 mg can interact with several medications, including:
Avoid using with:
-
Strong CYP3A4 inducers (e.g., Rifampin, Carbamazepine) – May reduce effectiveness.
-
CYP2D6 substrates (e.g., Metoprolol, Codeine) – Can alter drug levels.
-
Blood thinners (Warfarin, Heparin) – May increase the risk of bleeding.
-
Corticosteroids (other than prednisone) – Can disrupt hormone levels.
-
Heart medications (Digoxin, Amiodarone) – Can cause heart complications.
Allergy Warnings
-
Do not use if allergic to Abiraterone Acetate or any ingredients in Samtica.
-
Signs of allergy: Rash, swelling, severe itching, difficulty breathing.
-
Seek emergency medical help if an allergic reaction occurs.
Storage Instructions
-
Store at room temperature (15-30°C or 59-86°F).
-
Keep in a dry place, away from moisture and direct sunlight.
-
Keep out of reach of children.
-
Do not use expired medication.
Overdose Information
Symptoms of overdose:
-
Severe dizziness or fainting
-
Irregular heartbeat
-
Confusion or difficulty breathing
What to do in case of overdose?
-
Seek emergency medical help immediately.
-
Visit the nearest hospital or call a poison control center.
Missed Dose Instructions
-
If you miss a dose, take it as soon as you remember.
-
If it is almost time for the next dose, skip the missed dose—do not take a double dose.
-
Never take extra tablets to make up for a missed dose.
Additional Notes:
-
Regular monitoring is required for liver function, blood pressure, and potassium levels.
-
Do not stop taking the medication suddenly without a doctor’s guidance.
-
A healthy diet and exercise may improve treatment outcomes.
