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Abirapro 250mg - Abiraterone Acetate Tablets

Abirapro 250mg (Abiraterone Acetate) treats advanced prostate cancer by blocking testosterone production. Taken with prednisone, it slows cancer growth and improves survival. 💊🎗️

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General Information
Generic Name: Abiraterone Acetate
Brand Name: Abirapro
Packing: 120 tablets
Strength: 250mg
Manufacturer: Glenmark Pharmaceuticals Ltd.
Form: Tablet
Category: Anti-cancer (Androgen Biosynthesis Inhibitor)
Product Introduction
Abirapro 250mg is a potent androgen biosynthesis inhibitor used to treat metastatic prostate cancer. It helps slow the progression of cancer by blocking androgen (male hormone) production, which fuels prostate cancer growth. Abirapro is a trusted treatment option for metastatic castration-resistant prostate cancer (mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC), often prescribed in combination with prednisone to improve effectiveness and minimize side effects.

Uses of Abirapro 250mg
Abirapro 250mg is prescribed for:
  1. Metastatic Castration-Resistant Prostate Cancer (mCRPC) – Prostate cancer that continues to spread despite hormone therapy.
  2. Metastatic High-Risk Castration-Sensitive Prostate Cancer (mCSPC) – Newly diagnosed prostate cancer that has spread beyond the prostate gland.
  3. Combination Therapy with Prednisone – Enhances the drug’s effectiveness and reduces side effects.
  4. Reducing PSA Levels – Helps lower prostate-specific antigen (PSA), a marker of cancer progression.
  5. Slowing Disease Progression – Inhibits tumor growth and delays the need for chemotherapy.
  6. Improving Quality of Life – Helps manage symptoms like bone pain and urinary problems in prostate cancer patients.

How Abirapro 250mg Works
Abirapro 250mg contains Abiraterone Acetate, which is converted into Abiraterone in the body. It works by:
  1. Inhibiting the CYP17 Enzyme – This enzyme plays a key role in the production of androgens.
  2. Reducing Testosterone Production – Prostate cancer cells require testosterone to grow. Abirapro blocks its production from the testes, adrenal glands, and tumor cells.
Suppressing Tumor Growth – By cutting off the hormone supply, it slows the cancer’s spread and improves survival.

Dosage
  1. Recommended Dose: 1000mg (4 tablets of 250mg) once daily
  2. Combination Therapy: Typically taken with Prednisone 5mg twice daily
  3. Duration: Continued as long as clinical benefit is observed and side effects are manageable

Method of Administration
How to Take Abirapro 250mg:
  1. Take on an empty stomach – At least 1 hour before or 2 hours after eating.
  2. Swallow whole with water – Do not crush, chew, or break the tablet.
  3. Take at the same time daily for consistent results.
  4. Avoid grapefruit juice, as it may interfere with metabolism.

Side Effects
Common Side Effects:
  1. Fatigue
  2. High blood pressure (hypertension)
  3. Joint pain (arthralgia)
  4. Nausea and vomiting
  5. Fluid retention (swelling in legs or hands)
  6. Increased cholesterol levels
Severe Side Effects:
  1. Liver toxicity (elevated liver enzymes)
  2. Low potassium levels (hypokalemia)
  3. Irregular heartbeat (arrhythmia)
  4. Increased risk of infections
  5. Adrenal insufficiency (low cortisol levels)

Seek medical help if you experience severe side effects such as chest pain, dizziness, fainting, or yellowing of the skin.


Precautions
Before Taking Abirapro 250mg, Inform Your Doctor If You:
  1. Have liver disease – May require dose adjustment.
  2. Have heart problems – Can increase blood pressure and cardiac risks.
  3. Have low potassium levels – Can cause dangerous heart rhythm changes.
  4. Are diabetic – May require blood sugar monitoring due to prednisone use.
  5. Are planning to father a child – Can affect fertility; contraception is recommended.
Not for Use in:
  1. Women, especially pregnant or breastfeeding women
  2. Children under 18 years

Drug Interactions
Medicines That May Interact with Abirapro 250mg:
  1. Rifampin, Phenytoin, and Carbamazepine – May decrease effectiveness.
  2. Ketoconazole and itraconazole – Can increase the risk of side effects.
  3. Warfarin and Blood Thinners – May increase bleeding risk.
  4. Diuretics – Can lower potassium levels, increasing heart risks.
  5. ACE Inhibitors – May interfere with blood pressure control.
Inform your doctor about all medications, including supplements and herbal products.

Allergy Warnings
Do not take Abirapro 250mg if you are allergic to Abiraterone Acetate or its ingredients.
Symptoms of an allergic reaction include:
  1. Rash, itching, or swelling (especially of the face/tongue/throat)
  2. Severe dizziness
  3. Difficulty breathing

Storage Instructions
  1. Store in a cool, dry place below 30°C.
  2. Keep away from moisture and direct sunlight.
  3. Store in original packaging to protect from light.
  4. Keep out of reach of children and pets.

Overdose Information
In Case of Overdose:
  1. Seek immediate medical help.
  2. Symptoms may include severe weakness, confusion, high blood pressure, or irregular heartbeat.
Do NOT take a double dose to make up for a missed dose.

Missed Dose Instructions
  1. If you miss a dose: Take it as soon as you remember.
  2. If it’s close to your next dose: Skip the missed dose and take the next scheduled dose.
  3. Do not take two doses at the same time to make up for a missed one.

Additional Notes
  1. Regular blood tests (for liver function, potassium levels, and blood pressure) are necessary.
  2. Men should use effective contraception during and for 3 months after treatment.
  3. Avoid alcohol as it may worsen side effects.

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