Product Introduction:
Leuprosun 11.25mg is a depot formulation of Leuprolide Acetate, designed for extended-release over a 12-week period. It acts on the pituitary gland to suppress the release of sex hormones (testosterone and estrogen), making it effective in managing hormone-sensitive diseases. This injection is administered by a healthcare professional.
Uses:
Leuprosun 11.25mg is used for the treatment of:
-
Advanced Prostate Cancer – suppression of testosterone
-
Endometriosis – reduces estrogen and relieves symptoms
-
Uterine Fibroids – helps shrink fibroids before surgery or to manage symptoms
-
Central Precocious Puberty (CPP) – delays premature sexual development in children
-
Breast Cancer – hormone receptor-positive cases (in premenopausal women)
-
Fertility Treatments (IVF) – as part of ovarian stimulation protocols
Storage Instructions:
-
Store below 25°C (77°F)
-
Protect from light and moisture
-
Do not freeze
-
Use immediately after reconstitution
-
Keep away from children
How It Works (Mechanism of Action):
Leuprolide Acetate is a GnRH agonist. It initially stimulates the release of LH and FSH, causing a temporary increase in sex hormone levels (testosterone/estrogen). However, with continued use, it downregulates the pituitary receptors, ultimately suppressing the release of LH and FSH, resulting in low hormone levels that help slow or halt the progression of hormone-sensitive conditions.
Side Effects:
Common side effects include:
-
Hot flashes
-
Headache
-
Fatigue
-
Sweating
-
Decreased libido
-
Vaginal dryness (in women)
-
Injection site discomfort
Serious side effects may include:
-
Bone loss (osteoporosis)
-
Mood swings or depression
-
Irregular heart rhythm (QT prolongation)
-
High blood sugar (hyperglycemia or new-onset diabetes)
-
Initial tumor flare-up in prostate cancer
-
Allergic reactions (rash, difficulty breathing, swelling)
Dosage (Typical Recommended Dose):
-
One 11.25 mg injection administered once every 3 months (12 weeks)
-
Dosage schedule may vary depending on the indication and patient response
-
Must be administered by a trained healthcare provider
Method of Administration:
-
Given as a deep intramuscular (IM) or subcutaneous (SC) injection
-
Powder must be reconstituted with provided diluent before use
-
Administered by a healthcare professional only
-
Injection site should be rotated if receiving multiple doses
Precautions:
-
Not to be used during pregnancy or breastfeeding – may cause fetal harm
-
Use non-hormonal contraception during treatment
-
Monitor for mood changes, bone health, and cardiac function
-
May cause temporary worsening of symptoms (tumor flare) in the initial phase
-
Not recommended for use in patients with undiagnosed vaginal bleeding or hypersensitivity to GnRH agonists
Drug Interactions:
May interact with:
-
QT-prolonging medications (e.g., certain antiarrhythmics, antipsychotics)
-
Insulin or oral antidiabetics
-
Corticosteroids
-
Other hormone therapies or chemotherapeutic agents
Always inform your doctor about all medicines and supplements you are taking.
Allergies:
-
Contraindicated in individuals with a known hypersensitivity to Leuprolide Acetate, GnRH analogs, or any component of the injection
-
Allergic reactions can range from mild (rash, itching) to severe (swelling, difficulty breathing)
Overdose Information:
-
Overdose is rare due to depot formulation and medical administration
-
Symptoms may include hormonal imbalance, excessive suppression effects, or side effects
-
No specific antidote; supportive treatment is recommended
Missed Dose Instructions:
-
If a dose is missed or delayed, contact your healthcare provider promptly
-
Timely administration is essential to maintain hormonal suppression and therapeutic effectiveness
-
Avoid self-adjusting the schedule
Additional Notes:
-
Patients on long-term therapy may need bone density monitoring and calcium/vitamin D supplements
-
Regular monitoring of hormone levels, PSA (for prostate cancer), and clinical response is necessary
-
Inform your doctor if you experience severe mood changes, bone pain, or menstrual irregularities
-
Carry a treatment card or medical alert indicating use of hormonal therapy
Product Introduction:
Leuprosun 11.25mg is a depot formulation of Leuprolide Acetate, designed for extended-release over a 12-week period. It acts on the pituitary gland to suppress the release of sex hormones (testosterone and estrogen), making it effective in managing hormone-sensitive diseases. This injection is administered by a healthcare professional.
Uses:
Leuprosun 11.25mg is used for the treatment of:
-
Advanced Prostate Cancer – suppression of testosterone
-
Endometriosis – reduces estrogen and relieves symptoms
-
Uterine Fibroids – helps shrink fibroids before surgery or to manage symptoms
-
Central Precocious Puberty (CPP) – delays premature sexual development in children
-
Breast Cancer – hormone receptor-positive cases (in premenopausal women)
-
Fertility Treatments (IVF) – as part of ovarian stimulation protocols
Storage Instructions:
-
Store below 25°C (77°F)
-
Protect from light and moisture
-
Do not freeze
-
Use immediately after reconstitution
-
Keep away from children
How It Works (Mechanism of Action):
Leuprolide Acetate is a GnRH agonist. It initially stimulates the release of LH and FSH, causing a temporary increase in sex hormone levels (testosterone/estrogen). However, with continued use, it downregulates the pituitary receptors, ultimately suppressing the release of LH and FSH, resulting in low hormone levels that help slow or halt the progression of hormone-sensitive conditions.
Side Effects:
Common side effects include:
-
Hot flashes
-
Headache
-
Fatigue
-
Sweating
-
Decreased libido
-
Vaginal dryness (in women)
-
Injection site discomfort
Serious side effects may include:
-
Bone loss (osteoporosis)
-
Mood swings or depression
-
Irregular heart rhythm (QT prolongation)
-
High blood sugar (hyperglycemia or new-onset diabetes)
-
Initial tumor flare-up in prostate cancer
-
Allergic reactions (rash, difficulty breathing, swelling)
Dosage (Typical Recommended Dose):
-
One 11.25 mg injection administered once every 3 months (12 weeks)
-
Dosage schedule may vary depending on the indication and patient response
-
Must be administered by a trained healthcare provider
Method of Administration:
-
Given as a deep intramuscular (IM) or subcutaneous (SC) injection
-
Powder must be reconstituted with provided diluent before use
-
Administered by a healthcare professional only
-
Injection site should be rotated if receiving multiple doses
Precautions:
-
Not to be used during pregnancy or breastfeeding – may cause fetal harm
-
Use non-hormonal contraception during treatment
-
Monitor for mood changes, bone health, and cardiac function
-
May cause temporary worsening of symptoms (tumor flare) in the initial phase
-
Not recommended for use in patients with undiagnosed vaginal bleeding or hypersensitivity to GnRH agonists
Drug Interactions:
May interact with:
-
QT-prolonging medications (e.g., certain antiarrhythmics, antipsychotics)
-
Insulin or oral antidiabetics
-
Corticosteroids
-
Other hormone therapies or chemotherapeutic agents
Always inform your doctor about all medicines and supplements you are taking.
Allergies:
-
Contraindicated in individuals with a known hypersensitivity to Leuprolide Acetate, GnRH analogs, or any component of the injection
-
Allergic reactions can range from mild (rash, itching) to severe (swelling, difficulty breathing)
Overdose Information:
-
Overdose is rare due to depot formulation and medical administration
-
Symptoms may include hormonal imbalance, excessive suppression effects, or side effects
-
No specific antidote; supportive treatment is recommended
Missed Dose Instructions:
-
If a dose is missed or delayed, contact your healthcare provider promptly
-
Timely administration is essential to maintain hormonal suppression and therapeutic effectiveness
-
Avoid self-adjusting the schedule
Additional Notes:
-
Patients on long-term therapy may need bone density monitoring and calcium/vitamin D supplements
-
Regular monitoring of hormone levels, PSA (for prostate cancer), and clinical response is necessary
-
Inform your doctor if you experience severe mood changes, bone pain, or menstrual irregularities
-
Carry a treatment card or medical alert indicating use of hormonal therapy
