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Evermil 10mg - Everolimus Tablets

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Evermil 10mg - Everolimus Tablets

Evermil 10mg is an oral anticancer medicine used to treat various types of cancers and tumors. It works by inhibiting a protein called mTOR, which helps slow down the growth of cancer cells and reduces blood supply to tumors.

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Description Product Details
General Information:
Generic Name: Everolimus
Brand Name: Evermil
Packing: Strip of tablets
Strength: 10 mg
Manufacturer: Glenmark Pharmaceuticals
Form: Oral tablet
Category: Anticancer, mTOR inhibitor, Targeted therapy
Product Intro:
Evermil 10mg, manufactured by Glenmark Pharmaceuticals, contains Everolimus, an mTOR inhibitor used to treat multiple cancers including breast cancer, kidney cancer, and certain brain and pancreatic tumors. It also plays a role in preventing organ rejection post-transplant in other formulations.
Uses:
  1. Advanced hormone receptor-positive, HER2-negative breast cancer
  2. Advanced renal cell carcinoma (RCC)
  3. Neuroendocrine tumors of pancreatic origin (PNETs)
  4. Subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis
  5. Neuroendocrine tumors of gastrointestinal (GI) or lung origin
  6. Post-organ transplant immunosuppression (other Everolimus formulations)
Storage Instructions:
  1. Store below 25°C (77°F)
  2. Keep in a cool, dry place, away from light and moisture
  3. Keep out of reach of children
  4. Do not use if the packaging is torn or shows signs of tampering
How it Works (Mechanism of Action):
Everolimus is a selective mTOR (mammalian target of rapamycin) inhibitor. It works by:
  1. Blocking mTOR, a key protein in cancer cell growth, angiogenesis, and survival
  2. Inhibiting cell division and reducing tumor vascularization
  3. Slowing or stopping tumor growth and spread
This targeted therapy disrupts specific molecular pathways crucial for cancer progression.
Side Effects:
Common Side Effects:
  1. Mouth ulcers (stomatitis)
  2. Rash
  3. Fatigue
  4. Diarrhea
  5. Loss of appetite
  6. Cough and shortness of breath
Severe Side Effects:
  1. Non-infectious pneumonitis (lung inflammation)
  2. Infections (due to immune suppression)
  3. Kidney or liver dysfunction
  4. Delayed wound healing
  5. High blood sugar or cholesterol levels
  6. Increased risk of bleeding
Dosage (Typical Recommended Dose):
  1. Standard dose: 10 mg once daily for most cancer indications
  2. Dose may vary depending on cancer type, patient condition, and tolerance
  3. Dose adjustments may be necessary for side effects or organ dysfunction
  4. Always follow the oncologist’s prescribed regimen
Method of Administration:
  1. Take orally once daily, at the same time each day
  2. Swallow whole with a glass of water – do not crush or chew
  3. Can be taken with or without food, but maintain consistency
  4. Avoid grapefruit or grapefruit juice during treatment
Precautions:
  1. Monitor blood counts, liver and kidney function, and lipid levels
  2. Use with caution in patients with diabetes, lung disease, or infections
  3. Avoid live vaccines during treatment
  4. Not recommended during pregnancy or breastfeeding
  5. Use effective contraception during and for 8 weeks after the last dose
Drug Interactions:
  1. CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) – increase Everolimus levels
  2. CYP3A4 inducers (e.g., rifampicin, phenytoin) – reduce effectiveness
  3. Avoid use with grapefruit products
  4. May interact with immunosuppressants, anticoagulants, and anti-diabetic medications
Allergies:
  1. Contraindicated in patients with hypersensitivity to Everolimus or other rapamycin derivatives
  2. Signs of allergic reaction include:
    1. Hives or rash
    2. Difficulty breathing
    3. Swelling of face, lips, or throat
Overdose Information:
  1. Symptoms may include severe immunosuppression, infections, or organ toxicity
  2. No specific antidote available
  3. Provide symptomatic and supportive care
  4. Seek immediate medical help if overdose is suspected
Missed Dose Instructions:
  1. If a dose is missed, take it as soon as you remember on the same day
  2. If it's the next day, skip the missed dose—do not double the dose
  3. Resume regular schedule the following day
Additional Notes:
  1. Regular monitoring through blood tests, imaging, and physical exams is essential
  2. Stay hydrated and maintain a healthy oral hygiene routine to prevent mouth ulcers
  3. Inform your doctor about all current medications and supplements
  4. Notify your doctor immediately if you develop fever, cough, or difficulty breathing
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