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Faslodex 250mg - Fulvestrant Injection

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Faslodex 250mg - Fulvestrant Injection

Faslodex 250mg is a hormone therapy injection containing Fulvestrant, used for treating hormone receptor-positive metastatic breast cancer in postmenopausal women. It helps block estrogen activity to slow or stop cancer growth.

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Description Product Details
General Information:
Generic Name: Fulvestrant
Brand Name: Faslodex
Packing: Prefilled syringe / Vial
Strength: 250mg/5ml
Manufacturer: AstraZeneca
Form: Injection
Category: Hormonal therapy / Anti-estrogen
Product Intro:
Faslodex 250mg is a long-acting estrogen receptor antagonist administered via intramuscular injection. Manufactured by AstraZeneca, it is used primarily in advanced or metastatic breast cancer patients who have progressed following anti-estrogen therapy.
Uses:
Faslodex 250mg is used for:
  1. Hormone receptor-positive metastatic breast cancer in postmenopausal women
  2. Advanced breast cancer progression after prior endocrine therapy
  3. As monotherapy in patients who no longer respond to tamoxifen
  4. In combination with CDK4/6 inhibitors like palbociclib
  5. Estrogen receptor-positive, HER2-negative advanced breast cancer
  6. Adjuvant treatment in certain clinical trials
Storage Instructions:
  1. Store at 2°C to 8°C (refrigerated)
  2. Do not freeze
  3. Keep in original packaging until time of use
  4. Bring to room temperature before administration
How it Works (Mechanism of Action):
Fulvestrant is a selective estrogen receptor degrader (SERD). It binds competitively to estrogen receptors on tumors and causes their degradation, leading to downregulation of estrogen activity. This halts the growth of estrogen-dependent cancer cells.
Side Effects:
Common Side Effects:
  1. Injection site pain
  2. Nausea
  3. Fatigue
  4. Hot flashes
  5. Headache
  6. Back pain
Severe Side Effects:
  1. Elevated liver enzymes
  2. Allergic reactions (rash, itching, swelling)
  3. Blood clotting problems (rare)
  4. Vaginal bleeding (postmenopausal women)
  5. Severe abdominal pain
Dosage (Typical Recommended Dose):
  1. Initial dose: 500 mg on Days 0, 14, and 28
  2. Maintenance dose: 500 mg once monthly (every 28 days)
  3. Dosage is the same whether used alone or in combination (unless specified otherwise)
Method of Administration:
  1. Administered via intramuscular injection, slowly and deeply into the gluteal muscle
  2. Given by a healthcare professional
  3. Injection volume is split into two 5 ml injections (one per buttock) for a 500 mg dose
Precautions:
  1. Not for use in premenopausal women unless specified by a doctor
  2. Use cautiously in patients with liver impairment
  3. Regular liver function tests recommended
  4. Discuss if patient has a history of thrombosis or bleeding disorders
  5. Not recommended during pregnancy or breastfeeding
Drug Interactions:
  1. No major known drug-drug interactions, but caution advised when combined with:
    1. Anticoagulants (increased bleeding risk)
    2. Other hormonal therapies
  2. Inform the physician about all ongoing medications and supplements
Allergies:
  1. Contraindicated in individuals with known hypersensitivity to Fulvestrant or any of the excipients
  2. Discontinue immediately if allergic reactions such as rash, itching, or anaphylaxis occur
Overdose Information:
  1. Overdose is rare due to administration by a professional
  2. In case of accidental overdose, symptomatic treatment and monitoring are required
  3. Report any unusual symptoms immediately
Missed Dose Instructions:
  1. Contact your healthcare provider to reschedule
  2. Do not double the next dose
  3. Stick to the monthly schedule as prescribed
Additional Notes:
  1. Should be used under supervision of an oncologist
  2. Liver function monitoring is essential
  3. Effective contraception recommended during and up to 1 year after treatment for women of childbearing age
  4. Not a chemotherapy agent, but a hormonal (targeted) therapy
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