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Lenakast 10mg - Lenalidomide Capsules

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Lenakast 10mg - Lenalidomide Capsules

Lenakast 10mg is an oral immunomodulatory drug used to treat various blood cancers, including multiple myeloma and myelodysplastic syndromes. It helps inhibit abnormal cell growth and strengthens the immune response against cancer cells.

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Description Product Details
General Information:
Generic Name: Lenalidomide
Brand Name: Lenakast 10mg
Packing: Bottle of 30 capsules
Strength: 10mg
Manufacturer: Aprazer Healthcare Pvt. Ltd.
Form: Capsules
Category: Anti-cancer, Immunomodulatory Agent
Product Intro:
Lenakast 10mg contains Lenalidomide, a derivative of thalidomide, and is classified as an immunomodulatory agent. It is used either alone or in combination with other therapies to treat cancers of the blood and bone marrow. Lenakast is known for its anti-inflammatory, anti-angiogenic, and anti-tumor properties.
Uses:
Lenakast 10mg is prescribed for:
  1. Multiple Myeloma (MM) – usually in combination with dexamethasone
  2. Myelodysplastic Syndromes (MDS) – particularly in patients with deletion 5q cytogenetic abnormality
  3. Mantle Cell Lymphoma (MCL) – in relapsed or refractory settings
  4. Follicular and marginal zone lymphoma
  5. Chronic Lymphocytic Leukemia (CLL) – under clinical evaluation
  6. Maintenance therapy post-stem cell transplant in myeloma patients
Storage Instructions:
  1. Store below 25°C
  2. Protect from light and moisture
  3. Keep in the original packaging
  4. Keep out of reach of children
  5. Do not use past the expiry date
How it Works (Mechanism of Action):
Lenalidomide works through multiple mechanisms:
  1. Inhibits angiogenesis (formation of new blood vessels) which tumors need to grow
  2. Enhances immune system function by activating T cells and natural killer (NK) cells
  3. Inhibits proliferation and induces apoptosis (cell death) in cancer cells
  4. Reduces levels of inflammatory cytokines
Side Effects:
Common Side Effects:
  1. Fatigue
  2. Diarrhea or constipation
  3. Nausea
  4. Rash
  5. Low white blood cell count (neutropenia)
  6. Anemia or thrombocytopenia
Severe Side Effects:
  1. Blood clots (DVT/PE)
  2. Severe infections due to low immunity
  3. Liver toxicity
  4. Second primary malignancies
  5. Allergic reactions (Stevens-Johnson syndrome)
Dosage (Typical Recommended Dose):
  1. 10mg once daily on days 1 to 21 of a 28-day cycle (for multiple myeloma or MDS)
  2. Dose may vary based on indication, kidney function, and combination therapies
  3. Always follow oncologist’s prescription and cycle schedule
Method of Administration:
  1. Take the capsule orally with water, with or without food
  2. Swallow whole—do not open, crush, or chew
  3. Take at the same time each day
Precautions:
  1. Pregnancy Warning: Contraindicated—can cause severe birth defects
  2. Females of childbearing potential must use 2 forms of contraception
  3. Avoid blood donation and sperm donation during and for 4 weeks after therapy
  4. Periodic blood tests are required to monitor blood cell counts
  5. Avoid alcohol and grapefruit juice
Drug Interactions:
  1. Increased risk of thrombosis with erythropoietin-stimulating agents
  2. May interact with dexamethasone, warfarin, or chemotherapy drugs
  3. Use caution with CYP450 enzyme-affecting drugs
Allergies:
  1. Contraindicated in patients allergic to Lenalidomide or thalidomide
  2. Symptoms of allergy: rash, itching, swelling, severe dizziness, difficulty breathing
Overdose Information:
  1. Symptoms may include severe fatigue, weakness, or increased risk of infections
  2. Seek immediate medical attention or contact a poison control center if overdose is suspected
Missed Dose Instructions:
  1. If less than 12 hours late, take the missed dose as soon as remembered
  2. If more than 12 hours late, skip the dose—do not double dose
  3. Resume the normal schedule the next day
Additional Notes:
  1. Routine blood tests are essential before each treatment cycle
  2. Patients should be enrolled in a risk management program if required
  3. Patients must not share this medication with others
  4. Inform the doctor immediately if symptoms of blood clots occur (chest pain, swelling, shortness of breath)
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