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Abevmy 400mg - Bevacizumab Injections

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Abevmy 400mg - Bevacizumab Injections

Abevmy 400mg Injection contains Bevacizumab, a monoclonal antibody used to treat various types of cancers, including colorectal, lung, kidney, ovarian, and brain cancers. It works by blocking the formation of new blood vessels (angiogenesis) that supply tumors, thereby slowing cancer growth.

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Description Product Details
General Information:
Generic Name: Bevacizumab
Brand Name: Abevmy
Packing: Vial for Injection
Strength: 400mg/16mL
Company: Mylan Pharmaceuticals Pvt. Ltd.
Form: Solution for Intravenous Infusion
Category: Monoclonal Antibody, Anti-Cancer, VEGF Inhibitor
Product Introduction:
Abevmy 400mg is an anti-cancer (anti-angiogenic) monoclonal antibody that targets vascular endothelial growth factor (VEGF). By inhibiting VEGF, it prevents the formation of new blood vessels that tumors need to grow, starving cancer cells and slowing tumor progression. It is administered as an intravenous (IV) infusion under medical supervision.
Uses of Abevmy 400mg
Abevmy 400mg is used to treat:
  1. Metastatic Colorectal Cancer (mCRC) – In combination with chemotherapy.
  2. Non-Small Cell Lung Cancer (NSCLC) – Advanced or metastatic cases.
  3. Ovarian and Cervical Cancer – Used in combination therapy.
  4. Renal Cell Carcinoma (Kidney Cancer) – Advanced stages.
  5. Glioblastoma (Brain Cancer) – In cases of recurrence.
  6. Other Solid Tumors (Off-label Use) – As per the doctor’s recommendation.
How Abevmy 400mg Works (Mechanism of Action):
  1. Bevacizumab is a monoclonal antibody that binds to vascular endothelial growth factor (VEGF).
  2. VEGF promotes new blood vessel growth (angiogenesis), which tumors rely on for oxygen and nutrients.
  3. By blocking VEGF, Abevmy prevents the formation of new blood vessels, starving the tumor and slowing its growth.
Dosage of Abevmy 400mg
Typical Recommended Dose:
  1. Metastatic Colorectal Cancer (mCRC):
    1. 5 mg/kg IV every 2 weeks or 7.5 mg/kg IV every 3 weeks with chemotherapy.
  2. Non-Small Cell Lung Cancer (NSCLC):
    1. 15 mg/kg IV every 3 weeks in combination with chemotherapy.
  3. Renal Cell Carcinoma (Kidney Cancer):
    1. 10 mg/kg IV every 2 weeks.
  4. Glioblastoma (Brain Cancer):
    1. 10 mg/kg IV every 2 weeks as monotherapy.
📌 Doses may vary based on cancer type, patient weight, and doctor’s assessment.
Method of Administration (How to Take It)
  1. Given as an intravenous (IV) infusion in a hospital or clinic setting.
  2. First infusion: Given over 90 minutes; subsequent doses may be infused faster (30-60 min).
  3. Not given as a rapid IV injection due to risk of severe side effects.
  4. Premedication (anti-nausea drugs) may be given to reduce side effects.
Side Effects of Abevmy 400mg
Common Side Effects:
  1. High blood pressure (hypertension)
  2. Fatigue and weakness
  3. Nosebleeds (epistaxis)
  4. Nausea and vomiting
  5. Diarrhea or constipation
  6. Decreased appetite
Severe Side Effects (Seek Immediate Medical Help):
  1. Severe bleeding – Internal bleeding, vomiting blood, blood in stool.
  2. Wound healing complications – Delayed healing after surgery.
  3. Gastrointestinal perforation – Severe stomach pain, fever.
  4. Heart problems – Chest pain, irregular heartbeat.
  5. Kidney damage – Protein in urine, swelling in legs.
⚠️ Patients should undergo regular blood pressure and kidney function monitoring.
Precautions Before Taking Abevmy 400mg
  1. Not recommended in pregnancy – Can harm the unborn baby.
  2. Avoid if recent surgery – May delay wound healing.
  3. Monitor for hypertension – Regular blood pressure checks needed.
  4. Risk of blood clot formation – Caution in heart disease patients.
  5. Avoid in severe kidney or liver disease – Can worsen organ function.
Drug Interactions (Medications That May Interact)
Abevmy 400mg may interact with:
  1. Blood Thinners (Warfarin, Aspirin, Heparin): Increases bleeding risk.
  2. NSAIDs (Ibuprofen, Naproxen): May worsen kidney damage.
  3. Other Cancer Therapies: May enhance or reduce effectiveness.
  4. Immunosuppressants (Corticosteroids, Cyclosporine): May alter immune response.
  5. Surgery-related Medications: Stop Bevacizumab at least 28 days before and after surgery.
⚠️ Inform your doctor about any medications or supplements you are taking.
Allergy Warnings
  1. Do not take if allergic to Bevacizumab or its components.
  2. Signs of an allergic reaction:
    1. Severe rash or itching
    2. Swelling of face, lips, or throat
    3. Difficulty breathing
    4. Severe dizziness
🚨 Seek emergency medical help if allergic reactions occur.
Storage Instructions
  1. Store in a refrigerator at 2°C - 8°C.
  2. Do not freeze or shake the vial.
  3. Keep in original packaging, away from light.
  4. Use within the prescribed time after dilution.
Overdose Information
Symptoms of overdose:
  1. Severe hypertension (high blood pressure crisis)
  2. Excessive bleeding (nosebleeds, internal bleeding)
  3. Severe kidney or liver dysfunction
What to do in case of overdose?
  1. Seek immediate medical attention.
  2. Hospitalization and symptomatic treatment required.
Missed Dose Instructions
  1. Contact your doctor immediately if you miss a scheduled dose.
  2. Do not self-administer a missed dose.
  3. Do not double up on doses.

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