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Erlonat 150mg - Erlotinib Tablets

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Erlonat 150mg - Erlotinib Tablets

Erlonat 150mg is a targeted cancer therapy used in the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. It works by inhibiting the activity of epidermal growth factor receptors (EGFR), thereby slowing or stopping the growth of cancer cells.

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Description Product Details
General Information:
Generic Name: Erlotinib Hydrochloride
Brand Name: Erlonat
Packing: 30 tablets per bottle
Strength: 150 mg
Manufacturer: Natco Pharma Ltd.
Form: Oral Tablet
Category: Anti-cancer drug, EGFR Tyrosine Kinase Inhibitor
Product Intro:
Erlonat 150mg is an oral anti-cancer medication manufactured by Natco Pharma Ltd. It contains Erlotinib, a tyrosine kinase inhibitor that targets specific cancer cell growth pathways. It is commonly prescribed in advanced or metastatic cancer cases, especially when EGFR mutations are present.
Uses:
  1. Non-Small Cell Lung Cancer (NSCLC) – particularly with EGFR mutations
  2. Pancreatic Cancer – in combination with gemcitabine
  3. Second-line or maintenance therapy in advanced lung cancer
  4. Metastatic cancer cases with proven EGFR overexpression
  5. Off-label uses in other cancers (investigational, under medical supervision)
Storage Instructions:
  1. Store at room temperature (15–30°C)
  2. Keep away from heat, moisture, and direct sunlight
  3. Store in the original container, tightly closed
  4. Keep out of reach of children and pets
How it Works (Mechanism of Action):
Erlotinib inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR). This receptor is involved in the signaling pathways that promote cancer cell growth and survival. By blocking EGFR, Erlonat interferes with tumor cell proliferation and slows disease progression.
Side Effects:
Common Side Effects:
  1. Rash (acne-like)
  2. Diarrhea
  3. Nausea and vomiting
  4. Fatigue
  5. Loss of appetite
  6. Dry skin
Severe Side Effects:
  1. Interstitial lung disease (ILD) – serious lung inflammation
  2. Hepatotoxicity (liver function impairment)
  3. Gastrointestinal perforation (rare but critical)
  4. Severe diarrhea or dehydration
  5. Ocular disorders – keratitis, corneal perforation (rare)
Dosage (Typical Recommended Dose):
  1. NSCLC: 150 mg once daily on an empty stomach
  2. Pancreatic cancer (with gemcitabine): 100 mg once daily
  3. Dosage may be adjusted based on tolerance, side effects, or liver function
Method of Administration:
  1. Take the tablet orally, at least 1 hour before or 2 hours after meals
  2. Swallow whole with water
  3. Take it at the same time every day
  4. Do not crush, chew, or split the tablet
Precautions:
  1. Avoid sun exposure; use sunscreen to prevent rash
  2. Monitor for signs of lung or liver problems
  3. Use with caution in patients with hepatic or renal impairment
  4. Avoid grapefruit or grapefruit juice (may increase drug levels)
  5. Women of childbearing age should use effective contraception
  6. Not recommended during pregnancy or breastfeeding
Drug Interactions:
  1. Proton pump inhibitors (PPIs) – reduce drug absorption
  2. CYP3A4 inhibitors/inducers (e.g., ketoconazole, rifampicin) – alter metabolism
  3. Warfarin – increased risk of bleeding
  4. Statins – risk of muscle toxicity
  5. Smoking – reduces efficacy; patients should stop smoking
Allergies:
  1. Contraindicated in patients with hypersensitivity to Erlotinib
  2. Monitor for symptoms such as:
    1. Swelling
    2. Skin rash
    3. Shortness of breath
    4. Anaphylactic reaction (rare)
Overdose Information:
  1. Symptoms: Severe rash, diarrhea, liver enzyme elevation
  2. Action: Seek immediate medical attention
  3. Supportive care and symptom management are the mainstays of treatment
Missed Dose Instructions:
  1. Take the missed dose as soon as you remember if it’s not close to the next dose
  2. If it’s almost time for the next dose, skip the missed dose
  3. Do not double the dose to make up for the missed one
Additional Notes:
  1. Regular monitoring of liver function tests and complete blood counts is advised
  2. Report new or worsening symptoms to your doctor
  3. Therapy should be prescribed and monitored by an oncologist
  4. Do not share this medicine with others, even if they have similar symptoms
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