Buy Piciclib 125mg - Palbociclib Capsules Online, Piciclib 125mg

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Piciclib 125mg - Palbociclib Capsules

Piciclib 125mg is an oral anti-cancer medicine used in combination therapy for treating HR-positive, HER2-negative advanced breast cancer. It works by blocking enzymes essential for cancer cell division, helping to slow down or stop tumor progression.

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Description Product Details

General Information:

Generic Name: Palbociclib

Brand Name: Piciclib 125mg

Packing: Bottle of 21 capsules

Strength: 125 mg

Manufacturer: [To be added/customized]

Form: Oral Capsules

Category: Anti-cancer, CDK4/6 Inhibitor

Product Introduction:

Piciclib 125mg contains Palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor used to treat hormone receptor-positive breast cancer. It is taken orally and typically prescribed alongside hormone therapy like Letrozole or Fulvestrant to enhance the effectiveness of treatment in postmenopausal women or men with metastatic breast cancer.

Uses:

Piciclib 125mg is used for:

Hormone receptor (HR)-positive, HER2-negative advanced breast cancer
As first-line therapy with Letrozole
In combination with Fulvestrant for disease progression after hormone therapy
To delay cancer progression
Improve progression-free survival
Enhance overall response in advanced-stage disease

Storage Instructions:

Store below 25°C
Keep the bottle tightly closed and away from moisture
Protect from light and heat
Keep out of reach of children

How It Works (Mechanism of Action):

Palbociclib inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved in cell cycle regulation. Blocking these enzymes halts the cancer cell cycle at the G1 phase, preventing them from dividing and growing. This action slows the spread of hormone receptor-positive breast cancer cells.

Side Effects:

Common side effects:

Neutropenia (low white blood cells)
Fatigue
Diarrhea or constipation
Nausea
Hair thinning (alopecia)
Stomatitis (mouth sores)

Serious side effects:

Febrile neutropenia
Lung inflammation (rare)
Liver enzyme elevation
Increased risk of infections
Bleeding or easy bruising

Dosage (Typical Recommended Dose):

125 mg orally once daily for 21 days, followed by 7 days off (total 28-day cycle)
Taken with either Letrozole or Fulvestrant, depending on the treatment plan
Dose adjustments may be needed based on blood count results and tolerability

Method of Administration:

Take by mouth with food
Swallow capsule whole — do not open, crush, or chew
Take at the same time every day
Do not take extra if vomiting occurs after a dose

Precautions:

Regular CBC monitoring is essential due to risk of neutropenia
Not safe during pregnancy or breastfeeding
Use effective contraception during treatment and for several weeks after
Avoid contact with sick individuals due to risk of infection
Monitor for symptoms like fever, fatigue, or unusual bleeding

Drug Interactions:

Avoid strong CYP3A inhibitors/inducers (e.g., ketoconazole, rifampin)
Do not consume grapefruit or grapefruit juice
Inform your doctor about all prescription, OTC drugs, and supplements
May interact with antivirals, antibiotics, antifungals, and seizure medications

Allergies:

Rare allergic reactions possible – signs include rash, swelling, dizziness, or difficulty breathing
Discontinue use and seek immediate medical help if allergic symptoms occur

Overdose Information:

Symptoms may include fatigue, infections, severe nausea, or low blood counts
Seek emergency medical attention immediately
No specific antidote; treatment is supportive with careful monitoring

Missed Dose Instructions:

If you miss a dose, skip it and take the next dose at the regular time
Do not double the dose to make up for the missed one
Maintain a strict dosing schedule for optimal efficacy

Additional Notes:

Blood tests should be done before starting and during treatment
Patients should report symptoms of infection or bleeding early
Dietary support, hydration, and rest can help manage mild side effects
Capsule form should be handled with dry hands; do not crush or open
Regular follow-ups help monitor effectiveness and side effects