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Fulvira 250mg - Fulvestrant Injection

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Fulvira 250mg - Fulvestrant Injection

Fulvira 250mg is a hormone therapy injection used in the treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women. It works by blocking and degrading estrogen receptors in cancer cells.

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Description Product Details
General Information:
Generic Name: Fulvestrant
Brand Name: Fulvira
Packing: Single-use pre-filled syringe or vial
Strength: 250mg/5ml
Manufacturer: Emcure Pharmaceuticals Ltd.
Form: Injection
Category: Oncology / Hormonal Therapy / SERD
Product Intro:
Fulvira 250mg is a prescription anti-cancer medication used for hormone receptor-positive breast cancer. As a Selective Estrogen Receptor Degrader (SERD), it is commonly administered when other hormonal therapies have failed or become less effective. It is given as an intramuscular injection and is generally well-tolerated under clinical supervision.
Uses:
Fulvira 250mg is indicated for:
  1. Hormone receptor-positive metastatic breast cancer
  2. Breast cancer in postmenopausal women after disease progression on anti-estrogen therapy
  3. HER2-negative breast cancer in combination with other therapies
  4. Advanced breast cancer as first-line endocrine therapy
  5. Combination therapy with CDK4/6 inhibitors (like Palbociclib or Ribociclib)
  6. Disease progression after aromatase inhibitor therapy
Storage Instructions:
  1. Store at 2°C to 8°C (refrigerated)
  2. Do not freeze
  3. Keep in original packaging to protect from light
  4. Allow to reach room temperature before administration
  5. Keep out of reach of children
How it Works (Mechanism of Action):
Fulvestrant is a Selective Estrogen Receptor Degrader (SERD). It binds to estrogen receptors on cancer cells, blocking their activity and leading to their degradation. This prevents estrogen from stimulating the growth of hormone-dependent cancer cells.
Side Effects:
Common Side Effects:
  1. Hot flashes
  2. Injection site pain
  3. Headache
  4. Joint or muscle pain
  5. Fatigue
  6. Nausea
Severe Side Effects:
  1. Elevated liver enzymes
  2. Vaginal bleeding
  3. Thromboembolic events (blood clots)
  4. Hypersensitivity reactions including rash or anaphylaxis
Dosage (Typical Recommended Dose):
  1. Initial Dose: 500 mg intramuscularly on Days 1, 15, and 29
  2. Maintenance Dose: 500 mg once every 28 days thereafter
  3. Administered as two 5 mL injections (one in each buttock)
Method of Administration:
  1. Administered intramuscularly (IM) in the gluteal muscle
  2. Only by trained medical professionals
  3. Sites of injection should be alternated to avoid tissue irritation
Precautions:
  1. Not recommended during pregnancy or breastfeeding
  2. Use with caution in patients with liver dysfunction
  3. Regular liver function monitoring is advised
  4. Effective contraception required during and for at least 1 year after treatment
  5. Use caution in patients with a history of blood clots
Drug Interactions:
  1. Limited interactions known
  2. Use caution with:
    1. Blood thinners (e.g., warfarin)
    2. Other hormonal agents
  3. Always disclose all medications and supplements to the prescribing doctor
Allergies:
  1. Contraindicated in patients allergic to Fulvestrant or any component of the injection
  2. Signs of allergy include: swelling, rash, dizziness, difficulty breathing
  3. Seek immediate medical help if symptoms appear
Overdose Information:
  1. Overdose is rare due to professional administration
  2. Symptoms may include excessive nausea, dizziness, or liver dysfunction
  3. In case of suspected overdose, seek emergency medical help immediately
Missed Dose Instructions:
  1. If a dose is missed, consult the treating physician immediately
  2. Do not self-administer or double the dose
  3. Resume schedule based on professional advice
Additional Notes:
  1. Fulvira is typically part of a long-term treatment plan
  2. Regular medical evaluations and imaging tests may be required
  3. It is not a cure but helps manage hormone-sensitive breast cancer and improve survival rates
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