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Fulvenat 250mg - Fulvestrant Injection

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Fulvenat 250mg - Fulvestrant Injection

Fulvenat 250mg is a hormonal therapy injection containing Fulvestrant, used primarily to treat advanced or metastatic hormone receptor-positive breast cancer in postmenopausal women. It works by blocking estrogen receptors to slow or stop the growth of cancer cells.

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Description Product Details
General Information:
Generic Name: Fulvestrant
Brand Name: Fulvenat
Packing: Single-dose prefilled syringe or vial
Strength: 250mg/5ml
Manufacturer: Natco Pharma Ltd
Form: Injection
Category: Hormonal therapy / Estrogen receptor antagonist
Product Intro:
Fulvenat 250mg is a potent estrogen receptor antagonist designed to treat hormone receptor-positive breast cancer that has progressed after other endocrine therapies. This injection is administered intramuscularly and is typically used in postmenopausal women.
Uses:
Fulvenat is commonly used in the treatment of:
  1. Hormone receptor-positive metastatic breast cancer
  2. Advanced breast cancer following progression after anti-estrogen therapy
  3. As a monotherapy in postmenopausal women
  4. In combination with targeted therapies like CDK4/6 inhibitors (e.g., palbociclib)
  5. Estrogen receptor-positive, HER2-negative breast cancer
  6. Breast cancer not responsive to Tamoxifen
Storage Instructions:
  1. Store in a refrigerator between 2°C to 8°C
  2. Do not freeze
  3. Keep in original packaging and protect from light
  4. Allow to reach room temperature before injection
How it Works (Mechanism of Action):
Fulvestrant is a Selective Estrogen Receptor Degrader (SERD). It binds competitively to estrogen receptors on tumor cells, degrading the receptors and thereby reducing the estrogen signaling that supports the growth of breast cancer cells.
Side Effects:
Common Side Effects:
  1. Injection site pain or swelling
  2. Fatigue
  3. Headache
  4. Nausea
  5. Hot flashes
  6. Joint or muscle pain
Severe Side Effects:
  1. Liver function abnormalities
  2. Blood clot formation
  3. Vaginal bleeding
  4. Allergic reactions (rash, hives, swelling, difficulty breathing)
Dosage (Typical Recommended Dose):
  1. Initial dosing: 500mg on Days 1, 15, and 29
  2. Maintenance dose: 500mg once every 28 days thereafter
  3. Dose is split between two intramuscular injections
Method of Administration:
  1. Administered intramuscularly into the gluteal muscle
  2. Typically given by a healthcare provider
  3. Full 500mg dose is given as two 5 ml injections (one in each buttock)
Precautions:
  1. Not recommended for premenopausal women unless medically advised
  2. Use caution in patients with hepatic impairment
  3. Routine liver function tests recommended
  4. Avoid use during pregnancy and lactation
  5. Inform doctor of any bleeding disorders
Drug Interactions:
  1. Fulvestrant has no significant drug interactions, but caution is needed when used with:
    1. Anticoagulants (increased bleeding risk)
    2. Other hormonal agents
    3. Always disclose all medications and supplements
Allergies:
  1. Contraindicated in patients with known hypersensitivity to Fulvestrant or formulation ingredients
  2. Watch for signs of allergic reaction: rash, swelling, difficulty breathing
Overdose Information:
  1. Overdose is unlikely due to professional administration
  2. In case of overdose, supportive treatment should be given
  3. Seek immediate medical attention if overdose is suspected
Missed Dose Instructions:
  1. Contact the doctor immediately to reschedule a missed dose
  2. Do not double the next dose
  3. Continue following the prescribed monthly injection cycle
Additional Notes:
  1. Only to be administered by a qualified healthcare professional
  2. Regular monitoring of liver enzymes and clinical response is essential
  3. Effective contraception is recommended during treatment and for a period after
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